FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021716641> ?p ?o ?g. }

• W2021716641 endingPage "325" @default.
• W2021716641 startingPage "310" @default.
• W2021716641 abstract "Considering the wide variety of effects that have been reported to occur in the developmental neurotoxicity of chlorpyrifos (CP) and the lack of consensus on their dependence of brain acetylcholinesterase (AChE) activity inhibition, we applied microarray technology to explore dose-dependent alterations in transcriptional response in the fetal and maternal C57BL/6 mouse brain after daily gestational exposure (days 6 to 17) to CP (2, 4, 10, 12 or 15 mg/kg, sc). We identified significantly altered genes across doses and assessed for overrepresentation of Gene Ontology (GO) biological processes and KEGG pathways. We further clustered genes based on their expression profiles across doses and repeated the GO/pathways analysis for each cluster. The dose-effect relationship of CP on gene expression, both at the gene and pathway levels was non-monotonic and not necessarily related to brain AChE inhibition. The largest impact was observed in the 10mg/kg dose group which was also the LOAEL for brain AChE inhibition. In the maternal brain, lower doses (4 mg/kg) influenced GO categories and pathways such as cell adhesion, behavior, lipid metabolism, long-term potentiation, nervous system development, neurogenesis, synaptic transmission. In the fetal brain, lower doses (2 and/or 4 mg/kg) significantly altered cell division, translation, transmission of nerve impulse, chromatin modification, long-term potentiation. In addition, some genes involved in nervous system development and signaling were shown to be specifically influenced by these lower CP doses. Our approach was sensitive and reflected the diversity of responses known to be disrupted by CP and highlighted possible additional consequences of CP neurotoxicity, such as disturbance of the ubiquitin proteasome system." @default.
• W2021716641 created "2016-06-24" @default.
• W2021716641 creator A5001722260 @default.
• W2021716641 creator A5017464120 @default.
• W2021716641 creator A5024029360 @default.
• W2021716641 creator A5028081724 @default.
• W2021716641 creator A5041106552 @default.
• W2021716641 creator A5050596355 @default.
• W2021716641 creator A5073858859 @default.
• W2021716641 creator A5078101517 @default.
• W2021716641 date "2010-06-15" @default.
• W2021716641 modified "2023-10-14" @default.
• W2021716641 title "Toxicogenomic profiling in maternal and fetal rodent brains following gestational exposure to chlorpyrifos" @default.
• W2021716641 cites W1508349309 @default.
• W2021716641 cites W1584636459 @default.
• W2021716641 cites W1603850560 @default.
• W2021716641 cites W1970632511 @default.
• W2021716641 cites W1971048984 @default.
• W2021716641 cites W1971354169 @default.
• W2021716641 cites W1971708687 @default.
• W2021716641 cites W1972515739 @default.
• W2021716641 cites W1973415720 @default.
• W2021716641 cites W1979361034 @default.
• W2021716641 cites W1980262892 @default.
• W2021716641 cites W1980886866 @default.
• W2021716641 cites W1997057746 @default.
• W2021716641 cites W2010290406 @default.
• W2021716641 cites W2014782466 @default.
• W2021716641 cites W2021239799 @default.
• W2021716641 cites W2021807237 @default.
• W2021716641 cites W2021965613 @default.
• W2021716641 cites W2024791530 @default.
• W2021716641 cites W2027224551 @default.
• W2021716641 cites W2027260046 @default.
• W2021716641 cites W2028098691 @default.
• W2021716641 cites W2032624996 @default.
• W2021716641 cites W2032645727 @default.
• W2021716641 cites W2035672592 @default.
• W2021716641 cites W2042859546 @default.
• W2021716641 cites W2049469331 @default.
• W2021716641 cites W2051428774 @default.
• W2021716641 cites W2052893224 @default.
• W2021716641 cites W2054636717 @default.
• W2021716641 cites W2058705034 @default.
• W2021716641 cites W2065289459 @default.
• W2021716641 cites W2066253693 @default.
• W2021716641 cites W2067715785 @default.
• W2021716641 cites W2072009968 @default.
• W2021716641 cites W2078144023 @default.
• W2021716641 cites W2081098333 @default.
• W2021716641 cites W2085160034 @default.
• W2021716641 cites W2090806974 @default.
• W2021716641 cites W2094432825 @default.
• W2021716641 cites W2113103898 @default.
• W2021716641 cites W2117313899 @default.
• W2021716641 cites W2119804650 @default.
• W2021716641 cites W2120865735 @default.
• W2021716641 cites W2123894873 @default.
• W2021716641 cites W2128635872 @default.
• W2021716641 cites W2132493358 @default.
• W2021716641 cites W2132781112 @default.
• W2021716641 cites W2133235687 @default.
• W2021716641 cites W2137519255 @default.
• W2021716641 cites W2140872647 @default.
• W2021716641 cites W2141156480 @default.
• W2021716641 cites W2145594053 @default.
• W2021716641 cites W2145881748 @default.
• W2021716641 cites W2149676448 @default.
• W2021716641 cites W2153676981 @default.
• W2021716641 cites W2158217645 @default.
• W2021716641 cites W2160697532 @default.
• W2021716641 cites W45534775 @default.
• W2021716641 doi "https://doi.org/10.1016/j.taap.2010.03.015" @default.
• W2021716641 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2881838" @default.
• W2021716641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20350560" @default.
• W2021716641 hasPublicationYear "2010" @default.
• W2021716641 type Work @default.
• W2021716641 sameAs 2021716641 @default.
• W2021716641 citedByCount "42" @default.
• W2021716641 countsByYear W20217166412012 @default.
• W2021716641 countsByYear W20217166412013 @default.
• W2021716641 countsByYear W20217166412014 @default.
• W2021716641 countsByYear W20217166412015 @default.
• W2021716641 countsByYear W20217166412016 @default.
• W2021716641 countsByYear W20217166412017 @default.
• W2021716641 countsByYear W20217166412018 @default.
• W2021716641 countsByYear W20217166412019 @default.
• W2021716641 countsByYear W20217166412020 @default.
• W2021716641 countsByYear W20217166412021 @default.
• W2021716641 countsByYear W20217166412022 @default.
• W2021716641 countsByYear W20217166412023 @default.
• W2021716641 crossrefType "journal-article" @default.
• W2021716641 hasAuthorship W2021716641A5001722260 @default.
• W2021716641 hasAuthorship W2021716641A5017464120 @default.
• W2021716641 hasAuthorship W2021716641A5024029360 @default.
• W2021716641 hasAuthorship W2021716641A5028081724 @default.
• W2021716641 hasAuthorship W2021716641A5041106552 @default.
• W2021716641 hasAuthorship W2021716641A5050596355 @default.

• next