FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021724459> ?p ?o ?g. }

• W2021724459 endingPage "402" @default.
• W2021724459 startingPage "395" @default.
• W2021724459 abstract "This study was undertaken to assess the effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1), a known activator of soluble guanylyl cyclase, on formyl-l-methionyl-l-leucyl-l-phenylalanine (FMLP) and complement component 5a (C5a)-induced homotypic human neutrophil aggregation. YC-1 as well as the phosphodiesterase (PDE)4 inhibitors rolipram and Ro 20-1724, but not the PDE3 inhibitor milrinone, inhibited the aggregation responses stimulated by FMLP and C5a. In contrast, sodium nitroprusside (SNP) had no effect on FMLP- or C5a-induced neutrophil aggregation. Moreover, SNP together with YC-1 failed to modify the YC-1-induced responses. In addition, YC-1 and rolipram, but not milrinone, induced substantial increases in cAMP levels, which occurred through the inhibition of PDE activity but not an increase in adenylate cyclase function. Interestingly, adenosine deaminase abolished the inhibitory effects and cAMP levels of YC-1, rolipram, and Ro 20-1724. In conclusion, these results indicate that the inhibitory effect of YC-1 on homotypic neutrophil aggregation is attributed to an elevation in the cAMP concentration through inhibition of the activity of PDE, which may potentiate the autocrine functions of endogenous adenosine." @default.
• W2021724459 created "2016-06-24" @default.
• W2021724459 creator A5012786490 @default.
• W2021724459 creator A5013734423 @default.
• W2021724459 creator A5066358099 @default.
• W2021724459 date "2008-01-01" @default.
• W2021724459 modified "2023-10-17" @default.
• W2021724459 title "YC-1 attenuates homotypic human neutrophil aggregation through inhibition of phosphodiesterase activity" @default.
• W2021724459 cites W1557956840 @default.
• W2021724459 cites W1574175907 @default.
• W2021724459 cites W1628429461 @default.
• W2021724459 cites W183295734 @default.
• W2021724459 cites W1875166327 @default.
• W2021724459 cites W1929009802 @default.
• W2021724459 cites W1953704466 @default.
• W2021724459 cites W1968429293 @default.
• W2021724459 cites W1969164252 @default.
• W2021724459 cites W1990113288 @default.
• W2021724459 cites W1991058406 @default.
• W2021724459 cites W1991656668 @default.
• W2021724459 cites W1995279525 @default.
• W2021724459 cites W2017037090 @default.
• W2021724459 cites W2026475877 @default.
• W2021724459 cites W2028211677 @default.
• W2021724459 cites W2028965404 @default.
• W2021724459 cites W2029023072 @default.
• W2021724459 cites W2029491963 @default.
• W2021724459 cites W2034481155 @default.
• W2021724459 cites W2037691492 @default.
• W2021724459 cites W2040072601 @default.
• W2021724459 cites W2045374140 @default.
• W2021724459 cites W2047618829 @default.
• W2021724459 cites W2051605684 @default.
• W2021724459 cites W2069677924 @default.
• W2021724459 cites W2069881405 @default.
• W2021724459 cites W2071997158 @default.
• W2021724459 cites W2080274411 @default.
• W2021724459 cites W2083203405 @default.
• W2021724459 cites W2084267233 @default.
• W2021724459 cites W2090700025 @default.
• W2021724459 cites W2091138507 @default.
• W2021724459 cites W2101093001 @default.
• W2021724459 cites W2112736947 @default.
• W2021724459 cites W2114682332 @default.
• W2021724459 cites W2129667982 @default.
• W2021724459 cites W2149407335 @default.
• W2021724459 cites W2151679290 @default.
• W2021724459 cites W2160584096 @default.
• W2021724459 cites W2188677386 @default.
• W2021724459 cites W2276572803 @default.
• W2021724459 cites W2343207746 @default.
• W2021724459 cites W2410605540 @default.
• W2021724459 cites W2467657054 @default.
• W2021724459 cites W304581165 @default.
• W2021724459 cites W2402633375 @default.
• W2021724459 doi "https://doi.org/10.1016/j.ejphar.2007.10.022" @default.
• W2021724459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18001706" @default.
• W2021724459 hasPublicationYear "2008" @default.
• W2021724459 type Work @default.
• W2021724459 sameAs 2021724459 @default.
• W2021724459 citedByCount "6" @default.
• W2021724459 countsByYear W20217244592012 @default.
• W2021724459 crossrefType "journal-article" @default.
• W2021724459 hasAuthorship W2021724459A5012786490 @default.
• W2021724459 hasAuthorship W2021724459A5013734423 @default.
• W2021724459 hasAuthorship W2021724459A5066358099 @default.
• W2021724459 hasConcept C134018914 @default.
• W2021724459 hasConcept C155710745 @default.
• W2021724459 hasConcept C178790620 @default.
• W2021724459 hasConcept C181199279 @default.
• W2021724459 hasConcept C185592680 @default.
• W2021724459 hasConcept C2776645727 @default.
• W2021724459 hasConcept C2776846068 @default.
• W2021724459 hasConcept C2776958096 @default.
• W2021724459 hasConcept C2776991684 @default.
• W2021724459 hasConcept C2779610285 @default.
• W2021724459 hasConcept C519581460 @default.
• W2021724459 hasConcept C55493867 @default.
• W2021724459 hasConcept C58141971 @default.
• W2021724459 hasConcept C62826618 @default.
• W2021724459 hasConcept C86803240 @default.
• W2021724459 hasConcept C98274493 @default.
• W2021724459 hasConceptScore W2021724459C134018914 @default.
• W2021724459 hasConceptScore W2021724459C155710745 @default.
• W2021724459 hasConceptScore W2021724459C178790620 @default.
• W2021724459 hasConceptScore W2021724459C181199279 @default.
• W2021724459 hasConceptScore W2021724459C185592680 @default.
• W2021724459 hasConceptScore W2021724459C2776645727 @default.
• W2021724459 hasConceptScore W2021724459C2776846068 @default.
• W2021724459 hasConceptScore W2021724459C2776958096 @default.
• W2021724459 hasConceptScore W2021724459C2776991684 @default.
• W2021724459 hasConceptScore W2021724459C2779610285 @default.
• W2021724459 hasConceptScore W2021724459C519581460 @default.
• W2021724459 hasConceptScore W2021724459C55493867 @default.
• W2021724459 hasConceptScore W2021724459C58141971 @default.
• W2021724459 hasConceptScore W2021724459C62826618 @default.
• W2021724459 hasConceptScore W2021724459C86803240 @default.
• W2021724459 hasConceptScore W2021724459C98274493 @default.

• next