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- W2021727342 abstract "Hereditary cerebral amyloid angiopathy has been described in Icelandic and Dutch families. Although the clinical manifestations show similarities, biochemical characterization revealed that amyloid in the Icelandic patients consists of cystatin C and in the Dutch patients of beta-protein. Both diseases are caused by a single base mutation leading to the same amino acid (viz. glutamine). Furthermore, both cystatin C and the beta-protein precursor are protease inhibitors. Therefore, the mechanism of amyloidogenesis may be similar in both diseases. A comparison of clinical, pathological, genetic, and biochemical aspects of these two types of hereditary cerebral amyloid angiopathy is presented." @default.
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- W2021727342 date "1992-01-01" @default.
- W2021727342 modified "2023-10-16" @default.
- W2021727342 title "Comparison between the Icelandic and Dutch forms of hereditary cerebral amyloid angiopathy" @default.
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- W2021727342 doi "https://doi.org/10.1016/0303-8467(92)90031-w" @default.
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