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- W2021736291 abstract "Immunoelectron microscopic study on the interaction between the immune complexes and the local vascular components in nephrotoxic nephritis and ARTHUS type skin reaction was carried out. Conventional histologic and fluorescent antibody observations were also made for reference.The mechanism of the beginning and progression of nephrotoxic nephritis was as follows: The initial binding of heterologous anti-kidney antibodies to the intrarenal antigenic determinants, which were supposed to be concentrated mainly along the laminae densae of the glomerular basement membranes and partially in the mesangial matrices, and followed by gradually increased incorporation of complement β1c-components. The hitherto formed immune complexes then appeared in the lamina rarae int. of the basement membranes and in the mesangial areas by non-immunological transportation and deposition. The successive interactions between the immune complexes and the mesangial cells were assumed to be the essential factor to generate varied features of morphological alterations in the mesangial areas and in other glomerular components.Although this mechanism at the mesangial level had much similarity with the interaction between the deposited immune complexes and the pericytes of the target blood vessels in vasculitis of the AKTHUS type, the causative factor of continuated inflammatory reactions in the glomeruli of the nephrotoxic nephritis were discussed from both immunological and morphological points. ACTA PATH. JAP. 19: 265˜281, 1969." @default.
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- W2021736291 date "1969-08-01" @default.
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- W2021736291 title "IMMUNOELECTRON MICROSCOPIC STUDIES ON LOCAL VASCULAR CHANGES AFTER IMMUNOLOGICAL TISSUE INJURIES" @default.
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- W2021736291 doi "https://doi.org/10.1111/j.1440-1827.1969.tb00708.x" @default.
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