Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021750684> ?p ?o ?g. }
- W2021750684 endingPage "728" @default.
- W2021750684 startingPage "715" @default.
- W2021750684 abstract "Dynamic interactions between membrane and cytoskeleton components are crucial for T cell antigen recognition and subsequent cellular activation. We report here that the membrane-microfilament linker ezrin plays an important role in these processes. First, ezrin relocalizes to the contact area between T cells and stimulatory antigen-presenting cells (APCs), accumulating in F-actin-rich membrane protrusions at the periphery of the immunological synapse. Second, T cell receptor (TCR)-mediated intracellular signals are sufficient to induce ezrin relocalization, indicating that this protein is an effector of TCR signaling. Third, overexpression of the membrane binding domain of ezrin perturbs T cell receptor clustering in the T cell-APC contact area and inhibits the activation of nuclear factor for activated T cells (NF-AT)." @default.
- W2021750684 created "2016-06-24" @default.
- W2021750684 creator A5016612071 @default.
- W2021750684 creator A5018736500 @default.
- W2021750684 creator A5027793634 @default.
- W2021750684 creator A5043627793 @default.
- W2021750684 creator A5055249819 @default.
- W2021750684 creator A5060639488 @default.
- W2021750684 creator A5067648833 @default.
- W2021750684 creator A5077421907 @default.
- W2021750684 creator A5082498739 @default.
- W2021750684 date "2001-11-01" @default.
- W2021750684 modified "2023-10-17" @default.
- W2021750684 title "The Membrane-Microfilament Linker Ezrin Is Involved in the Formation of the Immunological Synapse and in T Cell Activation" @default.
- W2021750684 cites W1493336035 @default.
- W2021750684 cites W1545383778 @default.
- W2021750684 cites W1562441478 @default.
- W2021750684 cites W1567462163 @default.
- W2021750684 cites W1576944993 @default.
- W2021750684 cites W1585445496 @default.
- W2021750684 cites W1964484264 @default.
- W2021750684 cites W1973730600 @default.
- W2021750684 cites W1977917516 @default.
- W2021750684 cites W1989342624 @default.
- W2021750684 cites W1995811820 @default.
- W2021750684 cites W1996275548 @default.
- W2021750684 cites W1998932713 @default.
- W2021750684 cites W2015757829 @default.
- W2021750684 cites W2019286212 @default.
- W2021750684 cites W2029863963 @default.
- W2021750684 cites W2035562653 @default.
- W2021750684 cites W2036802726 @default.
- W2021750684 cites W2039529577 @default.
- W2021750684 cites W2041247573 @default.
- W2021750684 cites W2042704418 @default.
- W2021750684 cites W2043893491 @default.
- W2021750684 cites W2047575901 @default.
- W2021750684 cites W2047784800 @default.
- W2021750684 cites W2060712092 @default.
- W2021750684 cites W2068474691 @default.
- W2021750684 cites W2069945609 @default.
- W2021750684 cites W2071442472 @default.
- W2021750684 cites W2071946819 @default.
- W2021750684 cites W2078108429 @default.
- W2021750684 cites W2079681700 @default.
- W2021750684 cites W2093897057 @default.
- W2021750684 cites W2095359507 @default.
- W2021750684 cites W2095773895 @default.
- W2021750684 cites W2096234619 @default.
- W2021750684 cites W2105567655 @default.
- W2021750684 cites W2107383749 @default.
- W2021750684 cites W2112630320 @default.
- W2021750684 cites W2112981236 @default.
- W2021750684 cites W2117524604 @default.
- W2021750684 cites W2129558898 @default.
- W2021750684 cites W2130436369 @default.
- W2021750684 cites W2133880323 @default.
- W2021750684 cites W2133931936 @default.
- W2021750684 cites W2138405576 @default.
- W2021750684 cites W2142091434 @default.
- W2021750684 cites W2144476583 @default.
- W2021750684 cites W2145556184 @default.
- W2021750684 cites W2147469756 @default.
- W2021750684 cites W2150338540 @default.
- W2021750684 cites W2150769903 @default.
- W2021750684 cites W2166452418 @default.
- W2021750684 cites W2168338776 @default.
- W2021750684 cites W232306754 @default.
- W2021750684 cites W2334268830 @default.
- W2021750684 doi "https://doi.org/10.1016/s1074-7613(01)00225-4" @default.
- W2021750684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11728334" @default.
- W2021750684 hasPublicationYear "2001" @default.
- W2021750684 type Work @default.
- W2021750684 sameAs 2021750684 @default.
- W2021750684 citedByCount "181" @default.
- W2021750684 countsByYear W20217506842012 @default.
- W2021750684 countsByYear W20217506842013 @default.
- W2021750684 countsByYear W20217506842014 @default.
- W2021750684 countsByYear W20217506842015 @default.
- W2021750684 countsByYear W20217506842016 @default.
- W2021750684 countsByYear W20217506842017 @default.
- W2021750684 countsByYear W20217506842018 @default.
- W2021750684 countsByYear W20217506842019 @default.
- W2021750684 countsByYear W20217506842020 @default.
- W2021750684 countsByYear W20217506842021 @default.
- W2021750684 countsByYear W20217506842022 @default.
- W2021750684 countsByYear W20217506842023 @default.
- W2021750684 crossrefType "journal-article" @default.
- W2021750684 hasAuthorship W2021750684A5016612071 @default.
- W2021750684 hasAuthorship W2021750684A5018736500 @default.
- W2021750684 hasAuthorship W2021750684A5027793634 @default.
- W2021750684 hasAuthorship W2021750684A5043627793 @default.
- W2021750684 hasAuthorship W2021750684A5055249819 @default.
- W2021750684 hasAuthorship W2021750684A5060639488 @default.
- W2021750684 hasAuthorship W2021750684A5067648833 @default.
- W2021750684 hasAuthorship W2021750684A5077421907 @default.
- W2021750684 hasAuthorship W2021750684A5082498739 @default.
- W2021750684 hasBestOaLocation W20217506841 @default.