Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021751981> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2021751981 endingPage "40" @default.
- W2021751981 startingPage "37" @default.
- W2021751981 abstract "This report describes the inhibition of protein kinase C (PKC) by a synthetic peptide corresponding to a viral sequence expressed in mammalian cells. The peptide corresponds to cytoplasmic domain residues 828–848 of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (gp41), and it inhibits Ca 2+ - and phosphatidylserine (PS)-dependent phosphorylation of synthetic peptide substrates and histone by purified PKC with IC 50 values ranging from 9 to 32 μM. Although previously described pKC-inhibitory synthetic peptides corresponding to sequences expressed in mammalian cells are also effective against the phosphorylation of synthetic peptide substrates, they fail to affect PKC-catalysed phosphorylation of potent protein substrates such as histone. This may limit their usefulness as inhibitors of PKC-catalysed protein phosphorylation in cellular systems. PKC activation is a major contributing factor in multidrug resistance (MDR) in cancer. Our observation that the synthetic peptide gp41(828–848) inhibits pKC-catalysed phosphorylation of a protein substrate suggests the potential value of expressing the viral sequence gp41(828–848) in cancer cells as a novel in vitro model system of MDR reversal." @default.
- W2021751981 created "2016-06-24" @default.
- W2021751981 creator A5020735619 @default.
- W2021751981 creator A5044105735 @default.
- W2021751981 creator A5080742650 @default.
- W2021751981 date "1995-01-01" @default.
- W2021751981 modified "2023-09-27" @default.
- W2021751981 title "Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828–848 of the human immunodeficiency virus type 1 envelope glycoprotein" @default.
- W2021751981 cites W1581479973 @default.
- W2021751981 cites W1587524494 @default.
- W2021751981 cites W1969710944 @default.
- W2021751981 cites W1974831705 @default.
- W2021751981 cites W1994367159 @default.
- W2021751981 cites W1996182665 @default.
- W2021751981 cites W2005870566 @default.
- W2021751981 cites W2007319015 @default.
- W2021751981 cites W2007683100 @default.
- W2021751981 cites W2091673674 @default.
- W2021751981 cites W2094987877 @default.
- W2021751981 cites W2142339245 @default.
- W2021751981 cites W2243210172 @default.
- W2021751981 doi "https://doi.org/10.1016/0304-3835(94)03610-u" @default.
- W2021751981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7850771" @default.
- W2021751981 hasPublicationYear "1995" @default.
- W2021751981 type Work @default.
- W2021751981 sameAs 2021751981 @default.
- W2021751981 citedByCount "1" @default.
- W2021751981 crossrefType "journal-article" @default.
- W2021751981 hasAuthorship W2021751981A5020735619 @default.
- W2021751981 hasAuthorship W2021751981A5044105735 @default.
- W2021751981 hasAuthorship W2021751981A5080742650 @default.
- W2021751981 hasConcept C11960822 @default.
- W2021751981 hasConcept C147483822 @default.
- W2021751981 hasConcept C153911025 @default.
- W2021751981 hasConcept C184235292 @default.
- W2021751981 hasConcept C195616568 @default.
- W2021751981 hasConcept C195794163 @default.
- W2021751981 hasConcept C203014093 @default.
- W2021751981 hasConcept C2776258796 @default.
- W2021751981 hasConcept C2779281246 @default.
- W2021751981 hasConcept C55493867 @default.
- W2021751981 hasConcept C86803240 @default.
- W2021751981 hasConceptScore W2021751981C11960822 @default.
- W2021751981 hasConceptScore W2021751981C147483822 @default.
- W2021751981 hasConceptScore W2021751981C153911025 @default.
- W2021751981 hasConceptScore W2021751981C184235292 @default.
- W2021751981 hasConceptScore W2021751981C195616568 @default.
- W2021751981 hasConceptScore W2021751981C195794163 @default.
- W2021751981 hasConceptScore W2021751981C203014093 @default.
- W2021751981 hasConceptScore W2021751981C2776258796 @default.
- W2021751981 hasConceptScore W2021751981C2779281246 @default.
- W2021751981 hasConceptScore W2021751981C55493867 @default.
- W2021751981 hasConceptScore W2021751981C86803240 @default.
- W2021751981 hasIssue "1" @default.
- W2021751981 hasLocation W20217519811 @default.
- W2021751981 hasLocation W20217519812 @default.
- W2021751981 hasOpenAccess W2021751981 @default.
- W2021751981 hasPrimaryLocation W20217519811 @default.
- W2021751981 hasRelatedWork W2033498478 @default.
- W2021751981 hasRelatedWork W2039853381 @default.
- W2021751981 hasRelatedWork W2042668741 @default.
- W2021751981 hasRelatedWork W2058545848 @default.
- W2021751981 hasRelatedWork W2062521580 @default.
- W2021751981 hasRelatedWork W227918356 @default.
- W2021751981 hasRelatedWork W2382491703 @default.
- W2021751981 hasRelatedWork W2433788552 @default.
- W2021751981 hasRelatedWork W4247019517 @default.
- W2021751981 hasRelatedWork W2136545008 @default.
- W2021751981 hasVolume "88" @default.
- W2021751981 isParatext "false" @default.
- W2021751981 isRetracted "false" @default.
- W2021751981 magId "2021751981" @default.
- W2021751981 workType "article" @default.