Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021780722> ?p ?o ?g. }
- W2021780722 endingPage "942" @default.
- W2021780722 startingPage "932" @default.
- W2021780722 abstract "The main focus of the present investigation is to evaluate a differential effect of adenosine on the up-regulation of vascular endothelial growth factor (VEGF) expression through adenosine A2 receptors in the rat tongue treated with endotoxin (lipopolysaccharide: LPS). Angiogenesis in the rat tongue treated with LPS/incomplete Freund's adjuvant (IFA) or endotoxin/IFA/adenosine A2 receptor (A2R) antagonists was examined using immunohistochemistry for LYVE-1, ED1, ED2, OX6, langerin and VEGF, and real-time polymerase chain reaction (PCR) for VEGF. The distributional density of both blood vessels and OX6+ cells was significantly increased at day 8 after injection of LPS/IFA. The immunoreactive products of VEGF were intensely labelled in the cytoplasm of various antigen presenting cells (APCs) including dendritic cells (DCs) with double-immunofluorescence technique. Increase in VEGF mRNA expression level, the occupancy ratio of blood vessels, and the number of ED1+, ED2+, OX6+, and langerin+ cells was inhibited in the injured tongue of rats as a consequence of the treatment with A2R antagonists. The present results indicate that the LPS-induced adenosine might promote angiogenesis by the up-regulation of VEGF expression in macrophages/DCs through A2 receptors. This suggests that the synergistic interaction between toll-like receptor (TLR) and A2 receptor signalling observed in vivo plays an important role in oral mucosal wound healing." @default.
- W2021780722 created "2016-06-24" @default.
- W2021780722 creator A5060262806 @default.
- W2021780722 creator A5068363038 @default.
- W2021780722 creator A5081222746 @default.
- W2021780722 creator A5089071534 @default.
- W2021780722 date "2009-10-01" @default.
- W2021780722 modified "2023-10-14" @default.
- W2021780722 title "Up-regulation of vascular endothelial growth factor expression by adenosine through adenosine A2 receptors in the rat tongue treated with endotoxin" @default.
- W2021780722 cites W1486575542 @default.
- W2021780722 cites W1501287464 @default.
- W2021780722 cites W1505264265 @default.
- W2021780722 cites W1529648101 @default.
- W2021780722 cites W1577861060 @default.
- W2021780722 cites W1661544713 @default.
- W2021780722 cites W1696233391 @default.
- W2021780722 cites W1930598094 @default.
- W2021780722 cites W1944355206 @default.
- W2021780722 cites W1967089661 @default.
- W2021780722 cites W1972261522 @default.
- W2021780722 cites W1972646344 @default.
- W2021780722 cites W1978043572 @default.
- W2021780722 cites W1982767795 @default.
- W2021780722 cites W1983763042 @default.
- W2021780722 cites W1985712533 @default.
- W2021780722 cites W1990113288 @default.
- W2021780722 cites W1992293535 @default.
- W2021780722 cites W1992884013 @default.
- W2021780722 cites W1992896836 @default.
- W2021780722 cites W1995266165 @default.
- W2021780722 cites W1999223106 @default.
- W2021780722 cites W2004465286 @default.
- W2021780722 cites W2012461372 @default.
- W2021780722 cites W2013297129 @default.
- W2021780722 cites W2014330166 @default.
- W2021780722 cites W2036751011 @default.
- W2021780722 cites W2039559578 @default.
- W2021780722 cites W2048320764 @default.
- W2021780722 cites W2049438805 @default.
- W2021780722 cites W2051275990 @default.
- W2021780722 cites W2053043145 @default.
- W2021780722 cites W2058703459 @default.
- W2021780722 cites W2058735411 @default.
- W2021780722 cites W2063557216 @default.
- W2021780722 cites W2064435123 @default.
- W2021780722 cites W2066227849 @default.
- W2021780722 cites W2067755082 @default.
- W2021780722 cites W2075827840 @default.
- W2021780722 cites W2077884399 @default.
- W2021780722 cites W2077971241 @default.
- W2021780722 cites W2080416259 @default.
- W2021780722 cites W2086541144 @default.
- W2021780722 cites W2101153911 @default.
- W2021780722 cites W2109509015 @default.
- W2021780722 cites W2114098415 @default.
- W2021780722 cites W2120190211 @default.
- W2021780722 cites W2122520085 @default.
- W2021780722 cites W2123840402 @default.
- W2021780722 cites W2124374185 @default.
- W2021780722 cites W2129667982 @default.
- W2021780722 cites W2134142368 @default.
- W2021780722 cites W2139076091 @default.
- W2021780722 cites W2140174959 @default.
- W2021780722 cites W2162991675 @default.
- W2021780722 cites W2163183512 @default.
- W2021780722 cites W2173637498 @default.
- W2021780722 cites W2254834000 @default.
- W2021780722 cites W2298323837 @default.
- W2021780722 cites W2465037556 @default.
- W2021780722 cites W88244701 @default.
- W2021780722 doi "https://doi.org/10.1016/j.archoralbio.2009.07.008" @default.
- W2021780722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19712927" @default.
- W2021780722 hasPublicationYear "2009" @default.
- W2021780722 type Work @default.
- W2021780722 sameAs 2021780722 @default.
- W2021780722 citedByCount "8" @default.
- W2021780722 countsByYear W20217807222012 @default.
- W2021780722 countsByYear W20217807222013 @default.
- W2021780722 countsByYear W20217807222015 @default.
- W2021780722 countsByYear W20217807222017 @default.
- W2021780722 crossrefType "journal-article" @default.
- W2021780722 hasAuthorship W2021780722A5060262806 @default.
- W2021780722 hasAuthorship W2021780722A5068363038 @default.
- W2021780722 hasAuthorship W2021780722A5081222746 @default.
- W2021780722 hasAuthorship W2021780722A5089071534 @default.
- W2021780722 hasConcept C126322002 @default.
- W2021780722 hasConcept C134018914 @default.
- W2021780722 hasConcept C158424129 @default.
- W2021780722 hasConcept C167734588 @default.
- W2021780722 hasConcept C170493617 @default.
- W2021780722 hasConcept C185592680 @default.
- W2021780722 hasConcept C2776991684 @default.
- W2021780722 hasConcept C2777025900 @default.
- W2021780722 hasConcept C2778491162 @default.
- W2021780722 hasConcept C2778754761 @default.
- W2021780722 hasConcept C2778938600 @default.
- W2021780722 hasConcept C2780394083 @default.
- W2021780722 hasConcept C67907053 @default.