FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021784903> ?p ?o ?g. }

• W2021784903 endingPage "196" @default.
• W2021784903 startingPage "189" @default.
• W2021784903 abstract "Our aim in this study was to investigate the characteristics of a diffuser-tipped optical fiber in producing tumor necrosis, compared to a standard bare-tipped fiber. The potential synergistic effect between thermal sensitization by metronidazole and interstitial laser hyperthermia (ILH)-induced tumor necrosis is also evaluated.ILH is a minimally invasive technique for the treatment of colorectal liver metastases. One of the major limitations is the size of tissue necrosis achieved by a single optical fiber. Use of cylindrical diffuser-tipped fibers and thermal sensitization of tumor cells by metronidazole may increase the size of tumor necrosis achieved by a single optical fiber.A model of colorectal cancer liver metastases in male inbred CBA mice was used. Laser hyperthermia was applied to tumor tissue using either a bare optical quartz fiber or a cylindrical diffuser-tipped fiber from a Medilas fibertom 4100 Nd:YAG surgical laser generator. Six hundred joules of energy was applied at two power settings, 5 and 10 watts, using bare- and diffuser-tipped fibers, respectively. The extent of necrosis was assessed by histological techniques. A similar study with three experimental groups was treated with 300 J of applied energy. Extent of immediate tumor necrosis was compared to that seen 24 h after ILH treatment. The third group, which had been treated with intraperitoneal metronidazole prior to ILH, was also assessed for tumor necrosis after 24 h and results compared with both the previous groups.ILH delivered using a cylindrical diffuser-tipped fiber resulted in a significantly larger diameter of tumor necrosis when compared to a bare-tipped fiber, for a given amount of applied energy. The differences were more significant at higher power settings. Six hundred joules of energy applied by ILH using a bare-tipped fiber at 5 and 10 watts produced 6.7 +/- 1.1 mm and 5.9 +/- 0.6 mm diameter of tumor necrosis, respectively. At equivalent settings, the diffuser-tipped fiber produced 7.7 +/- 1.0 mm and 8.1 +/- 0.6 mm diameter of tumor necrosis (p = 0.02 and p < 0.001). Using a diffuser-tipped fiber and an applied energy of 300 J delivered at 5 watts power, mean diameter of tumor necrosis immediately after treatment was 6.7 +/- 1.1 mm and after 24 h 7.9 +/- 1.3 mm (p = 0.006). Mean diameter of tumor necrosis 24 h after ILH in animals treated with metronidazole was 8.3 +/- 1.9 mm (p = 0.11).Diffuser-tipped optical fiber appears to significantly increase the diameter of ILH-induced tumor necrosis compared to the bare fiber. In contrast to the bare fiber, it enables the application of laser energy using higher power settings without compromising the diameter of tumor necrosis achieved. In animals treated with metronidazole, a trend towards increased tumor destruction at the tumor-host interface was seen on histolopathology. In addition, a trend towards increased diameter of tumor necrosis was also seen; however, statistical significance was not achieved." @default.
• W2021784903 created "2016-06-24" @default.
• W2021784903 creator A5001618669 @default.
• W2021784903 creator A5033322272 @default.
• W2021784903 creator A5034893498 @default.
• W2021784903 date "2002-08-01" @default.
• W2021784903 modified "2023-09-26" @default.
• W2021784903 title "Interstitial Laser Hyperthermia for Colorectal Liver Metastases: The Effect of Thermal Sensitization and the Use of a Cylindrical Diffuser Tip on Tumor Necrosis" @default.
• W2021784903 cites W1917822045 @default.
• W2021784903 cites W1977663256 @default.
• W2021784903 cites W1979095194 @default.
• W2021784903 cites W1993637194 @default.
• W2021784903 cites W1996569737 @default.
• W2021784903 cites W1998966672 @default.
• W2021784903 cites W1999521641 @default.
• W2021784903 cites W2033899965 @default.
• W2021784903 cites W2060090976 @default.
• W2021784903 cites W2090689274 @default.
• W2021784903 cites W2094308524 @default.
• W2021784903 cites W2141495875 @default.
• W2021784903 cites W2145956590 @default.
• W2021784903 cites W4232398989 @default.
• W2021784903 doi "https://doi.org/10.1089/104454702760230500" @default.
• W2021784903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12206720" @default.
• W2021784903 hasPublicationYear "2002" @default.
• W2021784903 type Work @default.
• W2021784903 sameAs 2021784903 @default.
• W2021784903 citedByCount "31" @default.
• W2021784903 countsByYear W20217849032012 @default.
• W2021784903 countsByYear W20217849032013 @default.
• W2021784903 countsByYear W20217849032014 @default.
• W2021784903 countsByYear W20217849032015 @default.
• W2021784903 countsByYear W20217849032017 @default.
• W2021784903 countsByYear W20217849032019 @default.
• W2021784903 countsByYear W20217849032021 @default.
• W2021784903 crossrefType "journal-article" @default.
• W2021784903 hasAuthorship W2021784903A5001618669 @default.
• W2021784903 hasAuthorship W2021784903A5033322272 @default.
• W2021784903 hasAuthorship W2021784903A5034893498 @default.
• W2021784903 hasConcept C120665830 @default.
• W2021784903 hasConcept C121332964 @default.
• W2021784903 hasConcept C126322002 @default.
• W2021784903 hasConcept C142724271 @default.
• W2021784903 hasConcept C192562407 @default.
• W2021784903 hasConcept C203014093 @default.
• W2021784903 hasConcept C2776217527 @default.
• W2021784903 hasConcept C2779949491 @default.
• W2021784903 hasConcept C2780565730 @default.
• W2021784903 hasConcept C2982854487 @default.
• W2021784903 hasConcept C503630168 @default.
• W2021784903 hasConcept C71924100 @default.
• W2021784903 hasConceptScore W2021784903C120665830 @default.
• W2021784903 hasConceptScore W2021784903C121332964 @default.
• W2021784903 hasConceptScore W2021784903C126322002 @default.
• W2021784903 hasConceptScore W2021784903C142724271 @default.
• W2021784903 hasConceptScore W2021784903C192562407 @default.
• W2021784903 hasConceptScore W2021784903C203014093 @default.
• W2021784903 hasConceptScore W2021784903C2776217527 @default.
• W2021784903 hasConceptScore W2021784903C2779949491 @default.
• W2021784903 hasConceptScore W2021784903C2780565730 @default.
• W2021784903 hasConceptScore W2021784903C2982854487 @default.
• W2021784903 hasConceptScore W2021784903C503630168 @default.
• W2021784903 hasConceptScore W2021784903C71924100 @default.
• W2021784903 hasIssue "4" @default.
• W2021784903 hasLocation W20217849031 @default.
• W2021784903 hasLocation W20217849032 @default.
• W2021784903 hasOpenAccess W2021784903 @default.
• W2021784903 hasPrimaryLocation W20217849031 @default.
• W2021784903 hasRelatedWork W15492996 @default.
• W2021784903 hasRelatedWork W1989384928 @default.
• W2021784903 hasRelatedWork W2021784903 @default.
• W2021784903 hasRelatedWork W2105698033 @default.
• W2021784903 hasRelatedWork W2141519886 @default.
• W2021784903 hasRelatedWork W2148782029 @default.
• W2021784903 hasRelatedWork W2161989939 @default.
• W2021784903 hasRelatedWork W2183169465 @default.
• W2021784903 hasRelatedWork W2616598886 @default.
• W2021784903 hasRelatedWork W2899084033 @default.
• W2021784903 hasVolume "20" @default.
• W2021784903 isParatext "false" @default.
• W2021784903 isRetracted "false" @default.
• W2021784903 magId "2021784903" @default.
• W2021784903 workType "article" @default.