FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021799076> ?p ?o ?g. }

• W2021799076 endingPage "8597" @default.
• W2021799076 startingPage "8589" @default.
• W2021799076 abstract "Functional abnormalities in the dorsal-anterior-cingulate-cortex (dACC) underlie anxiety disorders and specifically post-traumatic stress disorder (PTSD). Promising and common behavioral approaches have limited effectiveness and many subjects exhibit spontaneous recovery of fear, as also evident in animal models following extinction training. Here, we use low-frequency stimulation (LFS), a protocol shown to induce long-term depression, with the aim of affecting synaptic plasticity induced by fear acquisition and extinction. We use aversive conditioning of either tone or visual stimuli paired with an aversive air-puff to the eye in a trace-conditioning paradigm. We find that LFS in the nonhuman primate (<i>Macaca fascicularis</i>) dACC, when combined with extinction training, was successful in preventing spontaneous recovery of the memory 24–72 h following extinction. We simultaneously record single-units and local-field-potentials across the dACC, and show that LFS gradually depressed evoked responses. Moreover, this decrease in neural excitability predicted the successful reduction of overnight spontaneous recovery on a day-by-day basis. Finally, we show that this effect occurs when using either visual or auditory modality as the conditioned stimulus, and that the reduction was specific to the conditioned modality. Our results suggest that the primate dACC is actively involved in maintaining the original aversive memory, and propose that a combination of LFS with behavioral therapy might significantly improve treatment in severe cases." @default.
• W2021799076 created "2016-06-24" @default.
• W2021799076 creator A5011206891 @default.
• W2021799076 creator A5063807588 @default.
• W2021799076 creator A5087215751 @default.
• W2021799076 date "2012-06-20" @default.
• W2021799076 modified "2023-09-24" @default.
• W2021799076 title "Low-Frequency Stimulation Depresses the Primate Anterior-Cingulate-Cortex and Prevents Spontaneous Recovery of Aversive Memories" @default.
• W2021799076 cites W1519229252 @default.
• W2021799076 cites W1596079174 @default.
• W2021799076 cites W1781576227 @default.
• W2021799076 cites W1818033036 @default.
• W2021799076 cites W1967887989 @default.
• W2021799076 cites W1978489779 @default.
• W2021799076 cites W1980717857 @default.
• W2021799076 cites W1981062699 @default.
• W2021799076 cites W1983230739 @default.
• W2021799076 cites W1983968131 @default.
• W2021799076 cites W1984624029 @default.
• W2021799076 cites W1984624900 @default.
• W2021799076 cites W1989045560 @default.
• W2021799076 cites W1991036243 @default.
• W2021799076 cites W1992503298 @default.
• W2021799076 cites W1993361425 @default.
• W2021799076 cites W1995798947 @default.
• W2021799076 cites W1997714535 @default.
• W2021799076 cites W1998455072 @default.
• W2021799076 cites W2006628933 @default.
• W2021799076 cites W2009000833 @default.
• W2021799076 cites W2012013165 @default.
• W2021799076 cites W2012639198 @default.
• W2021799076 cites W2012740961 @default.
• W2021799076 cites W2021576575 @default.
• W2021799076 cites W2023379355 @default.
• W2021799076 cites W2024471230 @default.
• W2021799076 cites W2024910408 @default.
• W2021799076 cites W2026342961 @default.
• W2021799076 cites W2026720425 @default.
• W2021799076 cites W2028031351 @default.
• W2021799076 cites W2031167848 @default.
• W2021799076 cites W2036863219 @default.
• W2021799076 cites W2039506251 @default.
• W2021799076 cites W2042479971 @default.
• W2021799076 cites W2049812132 @default.
• W2021799076 cites W2060160772 @default.
• W2021799076 cites W2061405268 @default.
• W2021799076 cites W2064029491 @default.
• W2021799076 cites W2065623558 @default.
• W2021799076 cites W2069002240 @default.
• W2021799076 cites W2070094949 @default.
• W2021799076 cites W2070785687 @default.
• W2021799076 cites W2074269826 @default.
• W2021799076 cites W2075336613 @default.
• W2021799076 cites W2076445235 @default.
• W2021799076 cites W2081999660 @default.
• W2021799076 cites W2083201121 @default.
• W2021799076 cites W2083845601 @default.
• W2021799076 cites W2098070616 @default.
• W2021799076 cites W2108888119 @default.
• W2021799076 cites W2109873096 @default.
• W2021799076 cites W2114221514 @default.
• W2021799076 cites W2115274607 @default.
• W2021799076 cites W2115857124 @default.
• W2021799076 cites W2116330286 @default.
• W2021799076 cites W2120020525 @default.
• W2021799076 cites W2120055641 @default.
• W2021799076 cites W2121044460 @default.
• W2021799076 cites W2123208606 @default.
• W2021799076 cites W2124152744 @default.
• W2021799076 cites W2124572421 @default.
• W2021799076 cites W2130554406 @default.
• W2021799076 cites W2134201421 @default.
• W2021799076 cites W2140506445 @default.
• W2021799076 cites W2144079442 @default.
• W2021799076 cites W2145929703 @default.
• W2021799076 cites W2154014505 @default.
• W2021799076 cites W2156746271 @default.
• W2021799076 cites W2158553737 @default.
• W2021799076 cites W2161113761 @default.
• W2021799076 cites W2166892356 @default.
• W2021799076 cites W2167820351 @default.
• W2021799076 cites W2167821068 @default.
• W2021799076 doi "https://doi.org/10.1523/jneurosci.6481-11.2012" @default.
• W2021799076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6620973" @default.
• W2021799076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22723700" @default.
• W2021799076 hasPublicationYear "2012" @default.
• W2021799076 type Work @default.
• W2021799076 sameAs 2021799076 @default.
• W2021799076 citedByCount "40" @default.
• W2021799076 countsByYear W20217990762012 @default.
• W2021799076 countsByYear W20217990762013 @default.
• W2021799076 countsByYear W20217990762014 @default.
• W2021799076 countsByYear W20217990762015 @default.
• W2021799076 countsByYear W20217990762016 @default.
• W2021799076 countsByYear W20217990762017 @default.
• W2021799076 countsByYear W20217990762018 @default.
• W2021799076 countsByYear W20217990762019 @default.
• W2021799076 countsByYear W20217990762020 @default.

• next