Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021800980> ?p ?o ?g. }
- W2021800980 endingPage "14" @default.
- W2021800980 startingPage "1" @default.
- W2021800980 abstract "In this study, we show that interfering with the splicing machinery results in activation of the tumour-suppressor p53. The spliceosome was targeted by small interfering RNA-mediated knockdown of proteins associated with different small nuclear ribonucleoprotein complexes and by using the small-molecule splicing modulator TG003. These interventions cause: the accumulation of p53, an increase in p53 transcriptional activity and can result in p53-dependent G(1) cell cycle arrest. Mdm2 and MdmX are two key repressors of p53. We show that a decrease in MdmX protein level contributes to p53 activation in response to targeting the spliceosome. Interfering with the spliceosome also causes an increase in the rate of degradation of Mdm2. Alterations in splicing are linked with tumour development. There are frequently global changes in splicing in cancer. Our study suggests that p53 activation could participate in protection against potential tumour-promoting defects in the spliceosome. A number of known p53-activating agents affect the splicing machinery and this could contribute to their ability to upregulate p53. Preclinical studies indicate that tumours can be more sensitive than normal cells to small-molecule spliceosome inhibitors. Activation of p53 could influence the selective anti-tumour activity of this therapeutic approach." @default.
- W2021800980 created "2016-06-24" @default.
- W2021800980 creator A5000350565 @default.
- W2021800980 creator A5054799678 @default.
- W2021800980 creator A5063567528 @default.
- W2021800980 creator A5066472745 @default.
- W2021800980 creator A5070198722 @default.
- W2021800980 creator A5090959560 @default.
- W2021800980 date "2012-02-20" @default.
- W2021800980 modified "2023-10-17" @default.
- W2021800980 title "p53 is activated in response to disruption of the pre-mRNA splicing machinery" @default.
- W2021800980 cites W1547004942 @default.
- W2021800980 cites W1979693199 @default.
- W2021800980 cites W1979765627 @default.
- W2021800980 cites W1983489516 @default.
- W2021800980 cites W1984104797 @default.
- W2021800980 cites W1986077139 @default.
- W2021800980 cites W1989525457 @default.
- W2021800980 cites W1991539695 @default.
- W2021800980 cites W1993694367 @default.
- W2021800980 cites W1998790160 @default.
- W2021800980 cites W2000518319 @default.
- W2021800980 cites W2001952613 @default.
- W2021800980 cites W2002354671 @default.
- W2021800980 cites W2003971548 @default.
- W2021800980 cites W2011920499 @default.
- W2021800980 cites W2022329480 @default.
- W2021800980 cites W2027630134 @default.
- W2021800980 cites W2028599385 @default.
- W2021800980 cites W2029406352 @default.
- W2021800980 cites W2036907121 @default.
- W2021800980 cites W2038444562 @default.
- W2021800980 cites W2045959986 @default.
- W2021800980 cites W2046740096 @default.
- W2021800980 cites W2048618925 @default.
- W2021800980 cites W2052078379 @default.
- W2021800980 cites W2052931181 @default.
- W2021800980 cites W2059516801 @default.
- W2021800980 cites W2065776232 @default.
- W2021800980 cites W2066040214 @default.
- W2021800980 cites W2067258802 @default.
- W2021800980 cites W2068111833 @default.
- W2021800980 cites W2070023783 @default.
- W2021800980 cites W2072731004 @default.
- W2021800980 cites W2074097219 @default.
- W2021800980 cites W2076122895 @default.
- W2021800980 cites W2079076511 @default.
- W2021800980 cites W2083140349 @default.
- W2021800980 cites W2091818021 @default.
- W2021800980 cites W2096674266 @default.
- W2021800980 cites W2096891352 @default.
- W2021800980 cites W2101636442 @default.
- W2021800980 cites W2105575347 @default.
- W2021800980 cites W2107637402 @default.
- W2021800980 cites W2110082176 @default.
- W2021800980 cites W2110817748 @default.
- W2021800980 cites W2117450502 @default.
- W2021800980 cites W2117646314 @default.
- W2021800980 cites W2124469032 @default.
- W2021800980 cites W2125725576 @default.
- W2021800980 cites W2125946663 @default.
- W2021800980 cites W2127471603 @default.
- W2021800980 cites W2127692046 @default.
- W2021800980 cites W2141224144 @default.
- W2021800980 cites W2141926052 @default.
- W2021800980 cites W2143460288 @default.
- W2021800980 cites W2143889483 @default.
- W2021800980 cites W2148393113 @default.
- W2021800980 cites W2153489172 @default.
- W2021800980 cites W2155570392 @default.
- W2021800980 cites W2155742225 @default.
- W2021800980 cites W2155804510 @default.
- W2021800980 cites W2157446225 @default.
- W2021800980 cites W2157936723 @default.
- W2021800980 cites W2160444267 @default.
- W2021800980 cites W2161828210 @default.
- W2021800980 cites W2428075992 @default.
- W2021800980 doi "https://doi.org/10.1038/onc.2012.38" @default.
- W2021800980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22349816" @default.
- W2021800980 hasPublicationYear "2012" @default.
- W2021800980 type Work @default.
- W2021800980 sameAs 2021800980 @default.
- W2021800980 citedByCount "61" @default.
- W2021800980 countsByYear W20218009802012 @default.
- W2021800980 countsByYear W20218009802013 @default.
- W2021800980 countsByYear W20218009802014 @default.
- W2021800980 countsByYear W20218009802015 @default.
- W2021800980 countsByYear W20218009802016 @default.
- W2021800980 countsByYear W20218009802017 @default.
- W2021800980 countsByYear W20218009802018 @default.
- W2021800980 countsByYear W20218009802019 @default.
- W2021800980 countsByYear W20218009802020 @default.
- W2021800980 countsByYear W20218009802021 @default.
- W2021800980 countsByYear W20218009802022 @default.
- W2021800980 countsByYear W20218009802023 @default.
- W2021800980 crossrefType "journal-article" @default.
- W2021800980 hasAuthorship W2021800980A5000350565 @default.
- W2021800980 hasAuthorship W2021800980A5054799678 @default.