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- W2021804270 abstract "Aptamers are a class of therapeutic oligonucleotides that form specific three-dimensional structures that are dictated by their sequences. They are typically generated by an iterative screening process of complex nucleic acid libraries employing a process termed Systemic Evolution of Ligands by Exponential Enrichment (SELEX). SELEX has traditionally been performed using purified proteins, and cell surface receptors may be challenging to purify in their properly folded and modified conformations. Therefore, relatively few aptamers have been generated that bind cell surface receptors. However, improvements in recombinant fusion protein technology have increased the availability of receptor extracellular domains as purified protein targets, and the development of cell-based selection techniques has allowed selection against surface proteins in their native configuration on the cell surface. With cell-based selection, a specific protein target is not always chosen, but selection is performed against a target cell type with the goal of letting the aptamer choose the target. Several studies have demonstrated that aptamers that bind cell surface receptors may have functions other than just blocking receptor-ligand interactions. All cell surface proteins cycle intracellularly to some extent, and many surface receptors are actively internalized in response to ligand binding. Therefore, aptamers that bind cell surface receptors have been exploited for the delivery of a variety of cargoes into cells. This review focuses on recent progress and current challenges in the field of aptamer-mediated delivery." @default.
- W2021804270 created "2016-06-24" @default.
- W2021804270 creator A5012045092 @default.
- W2021804270 creator A5045259580 @default.
- W2021804270 date "2010-05-27" @default.
- W2021804270 modified "2023-10-10" @default.
- W2021804270 title "Aptamers for Targeted Drug Delivery" @default.
- W2021804270 cites W1506041617 @default.
- W2021804270 cites W1570650398 @default.
- W2021804270 cites W1583518890 @default.
- W2021804270 cites W1623426438 @default.
- W2021804270 cites W1912230311 @default.
- W2021804270 cites W1925850732 @default.
- W2021804270 cites W1966543080 @default.
- W2021804270 cites W1968405341 @default.
- W2021804270 cites W1974622319 @default.
- W2021804270 cites W1977282539 @default.
- W2021804270 cites W1978211895 @default.
- W2021804270 cites W1985290031 @default.
- W2021804270 cites W1997686479 @default.
- W2021804270 cites W1999910805 @default.
- W2021804270 cites W2001769615 @default.
- W2021804270 cites W2002961521 @default.
- W2021804270 cites W2011364690 @default.
- W2021804270 cites W2014909608 @default.
- W2021804270 cites W2015839993 @default.
- W2021804270 cites W2027978484 @default.
- W2021804270 cites W2031555302 @default.
- W2021804270 cites W2032359283 @default.
- W2021804270 cites W2034491455 @default.
- W2021804270 cites W2038167103 @default.
- W2021804270 cites W2041919391 @default.
- W2021804270 cites W2043266732 @default.
- W2021804270 cites W2044824066 @default.
- W2021804270 cites W2046851174 @default.
- W2021804270 cites W2053662322 @default.
- W2021804270 cites W2055119381 @default.
- W2021804270 cites W2057348359 @default.
- W2021804270 cites W2059281433 @default.
- W2021804270 cites W2062498920 @default.
- W2021804270 cites W2064036940 @default.
- W2021804270 cites W2070558900 @default.
- W2021804270 cites W2071182758 @default.
- W2021804270 cites W2073055972 @default.
- W2021804270 cites W2073066818 @default.
- W2021804270 cites W2076104117 @default.
- W2021804270 cites W2077130806 @default.
- W2021804270 cites W2079321730 @default.
- W2021804270 cites W2081911509 @default.
- W2021804270 cites W2082984134 @default.
- W2021804270 cites W2087670364 @default.
- W2021804270 cites W2087898800 @default.
- W2021804270 cites W2091632168 @default.
- W2021804270 cites W2096817768 @default.
- W2021804270 cites W2097623122 @default.
- W2021804270 cites W2103311193 @default.
- W2021804270 cites W2104525153 @default.
- W2021804270 cites W2106249361 @default.
- W2021804270 cites W2106592331 @default.
- W2021804270 cites W2112000341 @default.
- W2021804270 cites W2113091464 @default.
- W2021804270 cites W2113282092 @default.
- W2021804270 cites W2116511587 @default.
- W2021804270 cites W2120145250 @default.
- W2021804270 cites W2122424025 @default.
- W2021804270 cites W2123175900 @default.
- W2021804270 cites W2123922022 @default.
- W2021804270 cites W2127865078 @default.
- W2021804270 cites W2129360146 @default.
- W2021804270 cites W2129680188 @default.
- W2021804270 cites W2130389715 @default.
- W2021804270 cites W2133952187 @default.
- W2021804270 cites W2134247556 @default.
- W2021804270 cites W2135508499 @default.
- W2021804270 cites W2136797728 @default.
- W2021804270 cites W2137109655 @default.
- W2021804270 cites W2138612986 @default.
- W2021804270 cites W2142376043 @default.
- W2021804270 cites W2144775586 @default.
- W2021804270 cites W2149147994 @default.
- W2021804270 cites W2150814991 @default.
- W2021804270 cites W2155192875 @default.
- W2021804270 cites W2156113162 @default.
- W2021804270 cites W2156299972 @default.
- W2021804270 cites W2158583121 @default.
- W2021804270 cites W2168357995 @default.
- W2021804270 cites W28705092 @default.
- W2021804270 doi "https://doi.org/10.3390/ph3061761" @default.
- W2021804270 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4033951" @default.
- W2021804270 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27713328" @default.
- W2021804270 hasPublicationYear "2010" @default.
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