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- W2021808565 abstract "It has been postulated that the efficacy of interferon-beta1a in multiple sclerosis may be due to the induction of type 2 cytokines. In this report we demonstrate that after 3 months of therapy, there is no sustained alteration in the plasma levels of type 1 (IL-12, IL-1beta and TNF-alpha) or type 2 (IL-6, IL-10) cytokines, but rather repeated induction of both with each injection. Little alteration is seen in the profile of cytokines induced with time, despite a decline in side effects. This suggests that IFN-beta1a causes repeated transient modulation of cytokine expression, but no sustained deviation in the type 1/type 2 balance." @default.
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- W2021808565 date "1999-11-01" @default.
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- W2021808565 title "Changes in plasma cytokines induced by interferon-β1a treatment in patients with multiple sclerosis" @default.
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- W2021808565 doi "https://doi.org/10.1016/s0165-5728(99)00103-4" @default.
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