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• W2021815068 abstract "ABSTRACT The Thogoto virus ML protein suppresses interferon synthesis in infected cells. Nevertheless, a virus mutant lacking ML remained highly pathogenic in standard laboratory mice. It was strongly attenuated, however, in mice carrying the interferon-responsive Mx1 gene found in wild mice, demonstrating that enhanced interferon synthesis is protective only if appropriate antiviral effector molecules are present. Our study shows that the virulence-enhancing effects of some viral interferon antagonists may escape detection in conventional animal models." @default.
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• W2021815068 date "2004-10-15" @default.
• W2021815068 modified "2023-10-02" @default.
• W2021815068 title "Thogoto Virus Lacking Interferon-Antagonistic Protein ML Is Strongly Attenuated in Newborn <i>Mx1</i> -Positive but Not <i>Mx1</i> -Negative Mice" @default.
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• W2021815068 doi "https://doi.org/10.1128/jvi.78.20.11422-11424.2004" @default.
• W2021815068 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/521850" @default.
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