Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021815422> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2021815422 endingPage "199" @default.
- W2021815422 startingPage "190" @default.
- W2021815422 abstract "Acinetobacter calcoaceticus subsp. anitratus ( Herellea vaginicola ) is an important cause of nosocomial infection in our hospital where A. calcoaceticus subsp. anitratus is the most frequently isolated gram-negative species resistant to one or more of the aminoglycoside antibiotics. Of 167 strains tested for susceptibility to aminoglycosides, only 6 strains were found that were resistant to ≥128 μg of kanamycin per ml; all others were susceptible to ≤32 μg/ml. Five of these six strains were found to produce aminoglycoside-modifying enzymes. Two strains produced a phosphotransferase which mediates resistance to kanamycin and neomycin; three strains produced an acetyltransferase which mediates resistance to kanamycin, tobramycin, and amikacin (minimal inhibitory concentration ≥ 128 μg/ml for each drug). No strain with lower level resistance to kanamycin, tobramycin, or amikacin had enzyme activity. Fourteen strains resistant to gentamicin failed to show significant enzymatic modification of that antibiotic. Although agarose gel electrophoresis of deoxyribonucleic acid preparations from the enzyme-producing strains showed plasmid bands in all, no transfer of aminoglycoside resistance could be achieved, nor was it cured by exposure to novobiocin, ethidium bromide, acridine orange, heat, or prolonged storage. Resistance to mercuric chloride, present in 2 of 60 strains, was lost by 1 strain after exposure to novobiocin, and the loss of resistance was associated with an apparent deletion of plasmid deoxyribonucleic acid." @default.
- W2021815422 created "2016-06-24" @default.
- W2021815422 creator A5061176730 @default.
- W2021815422 creator A5068293016 @default.
- W2021815422 date "1979-02-01" @default.
- W2021815422 modified "2023-10-12" @default.
- W2021815422 title "Aminoglycoside-Modifying Enzymes Among Clinical Isolates of <i>Acinetobacter calcoaceticus</i> subsp. <i>anitratus</i> ( <i>Herellea vaginicola</i> ): Explanation for High-Level Aminoglycoside Resistance" @default.
- W2021815422 cites W1520270311 @default.
- W2021815422 cites W1561376678 @default.
- W2021815422 cites W1775749144 @default.
- W2021815422 cites W1927972199 @default.
- W2021815422 cites W1949766905 @default.
- W2021815422 cites W1952635464 @default.
- W2021815422 cites W1968921544 @default.
- W2021815422 cites W1979092066 @default.
- W2021815422 cites W1981248764 @default.
- W2021815422 cites W1983315152 @default.
- W2021815422 cites W1986798704 @default.
- W2021815422 cites W1991327982 @default.
- W2021815422 cites W1992273153 @default.
- W2021815422 cites W2001103327 @default.
- W2021815422 cites W2001158506 @default.
- W2021815422 cites W2015098348 @default.
- W2021815422 cites W2017905026 @default.
- W2021815422 cites W2020473641 @default.
- W2021815422 cites W2042811226 @default.
- W2021815422 cites W2065382742 @default.
- W2021815422 cites W2071617797 @default.
- W2021815422 cites W2087694314 @default.
- W2021815422 cites W2094082118 @default.
- W2021815422 cites W2136931384 @default.
- W2021815422 cites W2314734269 @default.
- W2021815422 cites W2411185737 @default.
- W2021815422 doi "https://doi.org/10.1128/aac.15.2.190" @default.
- W2021815422 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/352631" @default.
- W2021815422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/426512" @default.
- W2021815422 hasPublicationYear "1979" @default.
- W2021815422 type Work @default.
- W2021815422 sameAs 2021815422 @default.
- W2021815422 citedByCount "54" @default.
- W2021815422 countsByYear W20218154222013 @default.
- W2021815422 countsByYear W20218154222014 @default.
- W2021815422 countsByYear W20218154222015 @default.
- W2021815422 countsByYear W20218154222019 @default.
- W2021815422 countsByYear W20218154222023 @default.
- W2021815422 crossrefType "journal-article" @default.
- W2021815422 hasAuthorship W2021815422A5061176730 @default.
- W2021815422 hasAuthorship W2021815422A5068293016 @default.
- W2021815422 hasBestOaLocation W20218154222 @default.
- W2021815422 hasConcept C2775832221 @default.
- W2021815422 hasConcept C2775843808 @default.
- W2021815422 hasConcept C2775859738 @default.
- W2021815422 hasConcept C2775876089 @default.
- W2021815422 hasConcept C2777427914 @default.
- W2021815422 hasConcept C2777787772 @default.
- W2021815422 hasConcept C2778063948 @default.
- W2021815422 hasConcept C2778523567 @default.
- W2021815422 hasConcept C2778974779 @default.
- W2021815422 hasConcept C2780920689 @default.
- W2021815422 hasConcept C501593827 @default.
- W2021815422 hasConcept C86803240 @default.
- W2021815422 hasConcept C89423630 @default.
- W2021815422 hasConcept C94665300 @default.
- W2021815422 hasConceptScore W2021815422C2775832221 @default.
- W2021815422 hasConceptScore W2021815422C2775843808 @default.
- W2021815422 hasConceptScore W2021815422C2775859738 @default.
- W2021815422 hasConceptScore W2021815422C2775876089 @default.
- W2021815422 hasConceptScore W2021815422C2777427914 @default.
- W2021815422 hasConceptScore W2021815422C2777787772 @default.
- W2021815422 hasConceptScore W2021815422C2778063948 @default.
- W2021815422 hasConceptScore W2021815422C2778523567 @default.
- W2021815422 hasConceptScore W2021815422C2778974779 @default.
- W2021815422 hasConceptScore W2021815422C2780920689 @default.
- W2021815422 hasConceptScore W2021815422C501593827 @default.
- W2021815422 hasConceptScore W2021815422C86803240 @default.
- W2021815422 hasConceptScore W2021815422C89423630 @default.
- W2021815422 hasConceptScore W2021815422C94665300 @default.
- W2021815422 hasIssue "2" @default.
- W2021815422 hasLocation W20218154221 @default.
- W2021815422 hasLocation W20218154222 @default.
- W2021815422 hasLocation W20218154223 @default.
- W2021815422 hasOpenAccess W2021815422 @default.
- W2021815422 hasPrimaryLocation W20218154221 @default.
- W2021815422 hasRelatedWork W1606170043 @default.
- W2021815422 hasRelatedWork W2060124950 @default.
- W2021815422 hasRelatedWork W2083142800 @default.
- W2021815422 hasRelatedWork W2089376663 @default.
- W2021815422 hasRelatedWork W2132420050 @default.
- W2021815422 hasRelatedWork W2162699818 @default.
- W2021815422 hasRelatedWork W2381440010 @default.
- W2021815422 hasRelatedWork W2401601829 @default.
- W2021815422 hasRelatedWork W2416022559 @default.
- W2021815422 hasRelatedWork W2417116826 @default.
- W2021815422 hasVolume "15" @default.
- W2021815422 isParatext "false" @default.
- W2021815422 isRetracted "false" @default.
- W2021815422 magId "2021815422" @default.
- W2021815422 workType "article" @default.