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- W2021816904 abstract "Abstract Although numerous positron emission tomography ( PET ) studies with 18 F‐fluoro‐deoxyglucose ( FDG ) have reported quantitative results on cerebral glucose kinetics and consumption, there is a large variation between the absolute values found in the literature. One of the underlying causes is the inconsistent use of the lumped constants ( LC s), the derivation of which is often based on multiple assumptions that render absolute numbers imprecise and errors hard to quantify. We combined a kinetic FDG ‐ PET study with magnetic resonance spectroscopic imaging ( MRSI ) of glucose dynamics in Sprague–Dawley rats to obtain a more comprehensive view of brain glucose kinetics and determine a reliable value for the LC under isoflurane anaesthesia. Maps of T max / CMR glc derived from MRSI data and T max determined from PET kinetic modelling allowed to obtain an LC ‐independent CMR glc . The LC was estimated to range from 0.33 ± 0.07 in retrosplenial cortex to 0.44 ± 0.05 in hippocampus, yielding CMR glc between 62 ± 14 and 54 ± 11 μmol/min/100 g, respectively. These newly determined LC s for four distinct areas in the rat brain under isoflurane anaesthesia provide means of comparing the growing amount of FDG ‐ PET data available from translational studies. image The lumped constant (LC) is a correction factor employed to estimate the glucose metabolic rate ( CMR glc ) from the metabolic rate of a radioactive glucose analog such as 18 F‐fluorodeoxyglucose (FDG). By combining FDG positron emission tomography (PET) with magnetic resonance spectroscopic imaging (MRSI) of glucose dynamics, we determined the FDG LC in the rat brain under isoflurane anaesthesia." @default.
- W2021816904 created "2016-06-24" @default.
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- W2021816904 date "2014-02-19" @default.
- W2021816904 modified "2023-10-03" @default.
- W2021816904 title "MRS glucose mapping and PET joining forces: re-evaluation of the lumped constant in the rat brain under isoflurane anaesthesia" @default.
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- W2021816904 doi "https://doi.org/10.1111/jnc.12667" @default.
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