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- W2021817350 abstract "Copoly(d,l-lactic/glycolic acid) (PLGA) microspheres containing thyrotropin releasing hormone (TRH) were prepared using an in-water drying method through a (w/o)/w emulsion. Various factors which affect TRH release from microspheres were examined both in vitro and in vivo. The drug release was affected by the drug loading level, the molecular weight of PLGA, and the lactic acid/glycolic acid (LA/GA) ratio of PLGA. The effect of the drug loading level on the initial burst differed widely with changes in the molecular weight of PLGA. The initial burst increased with decreasing molecular weight of PLGA. After the initial burst, the release rate was dominated mainly by the degradation of PLGA; the lower the molecular weight of PLGA, the faster the release rate. The release rate was also affected by the LA/GA ratio of the PLGA. The microspheres prepared with a higher GA content of PLGA exhibited a faster release rate. In the in vivo study in rats, the microspheres also released the peptide sustainedly over a long period after s.c. injection." @default.
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- W2021817350 date "1991-06-01" @default.
- W2021817350 modified "2023-09-25" @default.
- W2021817350 title "Factors influencing the profiles of TRH release from copoly(d,l-lactic/glycolic acid) microspheres" @default.
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- W2021817350 doi "https://doi.org/10.1016/0378-5173(91)90108-z" @default.
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