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- W2021818481 abstract "Cu/Zn superoxide dismutase (SOD1) catalyzes the dismutation of superoxide radicals produced from biological oxidation and environmental stresses. A number of xenobiotics are toxic because they generate free radicals, such as superoxide and hydroxyl radicals, through a redox cycle. The xenobiotic responsive element (XRE) was located between the nt -268 and -262 region of the 5'-flanking sequence of theSOD1gene. Functional analyses of this element by deletion, mutations, and heterologous promoter systems confirmed that the expression of theSOD1gene was induced by a xenobiotic through the XRE. Gel mobility shift assays showed the xenobiotic inducible binding of the receptor-ligand complex to XRE. The cytoplasmic fraction from nontreated HepG2 cells also contains the factor as a cryptic form and prominently reveals its DNA-binding activity by incubation with βNFin vitro.These results suggest that the XRE participates in the induction of the ratSOD1gene by xenobiotics." @default.
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- W2021818481 date "1999-03-01" @default.
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- W2021818481 title "Xenobiotic-Responsive Element for the Transcriptional Activation of the Rat Cu/Zn Superoxide Dismutase Gene" @default.
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- W2021818481 doi "https://doi.org/10.1006/bbrc.1999.0299" @default.
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