FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021837354> ?p ?o ?g. }

• W2021837354 endingPage "802" @default.
• W2021837354 startingPage "791" @default.
• W2021837354 abstract "The antinociceptive effect of the methanolic extract (ME) and two triterpenes isolated from E. mosenii (Orchidaceae) has been investigated in chemical and thermal models of nociception in mice. The ME of E. mosenii (0.3-30 mg kg(-1), i.p. or 50-400 mg kg(-1), p.o.) produced dose-related, significant and long-lasting (4 to 6 h) inhibition of acetic acid-induced abdominal constriction, with ID50 values of 3.9 and 137.0 mg kg(-1), respectively. Pholidotin and 24-methylenecycloartenol isolated from E. mosenii (0.1-3.0 mg kg(-1), i.p.) also produced marked and dose-related inhibition of acetic acid-induced pain, with ID50 values of 0.9 and 1.1 mg kg(-1). However, these compounds and the ME were about 3- to 13-fold more potent at the level of ID50 than diclofenac when assessed in acetic acid-induced abdominal constriction. The ME of E. mosenii in the same range of doses produced dose-related inhibition of both phases of formalin-induced licking, with mean ID50 values for the first and the second phases of 0.9, 122.0 mg kg(-1) and 0.7, 258.0 mg kg(-1), respectively by i.p. or p.o. routes. In addition, the ME (0.3-30 mg kg(-1), i.p., or 50-400 mg kg(-1), p.o.) also caused dose-related inhibition of capsaicin-induced neurogenic pain with mean ID50 values of 5.2 and 130.0 mg kg(-1), respectively. Treatment of animals with naloxone (5 mg kg(-1), i.p.) completely reversed the antinociceptive effect caused by morphine (5 mg kg(-1), s.c.) and that caused by ME of E. mosenii (1 mg kg(-1), i.p.) when assessed against either phase of the formalin-induced pain. Furthermore, when assessed in the hot-plate test, ME (100 mg kg(-1), i.p.) and morphine (10 mg kg(-1), s.c.) caused significant increase in response latency. However, ME given daily for to 7 consecutive days did not develop tolerance to itself nor did it induce cross-tolerance to morphine. Taken together these data demonstrate that the ME of E. mosenii elicited pronounced antinociception, when assessed by i.p. or p.o. routes, against several models of pain. Its actions involve, at least in part, an interaction with opioid system, seeming no to be related with a non-specific peripheral or central depressant actions. Finally, the active principle(s) responsible for the antinociceptive action of E. mosenii is likely related to the presence of the triterpenes." @default.
• W2021837354 created "2016-06-24" @default.
• W2021837354 creator A5005839193 @default.
• W2021837354 creator A5009990459 @default.
• W2021837354 creator A5037890780 @default.
• W2021837354 creator A5043518143 @default.
• W2021837354 creator A5043712906 @default.
• W2021837354 creator A5056242920 @default.
• W2021837354 creator A5059520363 @default.
• W2021837354 date "2000-01-01" @default.
• W2021837354 modified "2023-10-01" @default.
• W2021837354 title "Antinociceptive properties of the methanolic extract and two triterpenes isolated from Epidendrum mosenii stems (Orchidaceae)" @default.
• W2021837354 cites W1966756774 @default.
• W2021837354 cites W1979921010 @default.
• W2021837354 cites W1983112432 @default.
• W2021837354 cites W1985127619 @default.
• W2021837354 cites W2029793005 @default.
• W2021837354 cites W2036712476 @default.
• W2021837354 cites W2037175900 @default.
• W2021837354 cites W2038141648 @default.
• W2021837354 cites W2057233762 @default.
• W2021837354 cites W2058742288 @default.
• W2021837354 cites W2069953418 @default.
• W2021837354 cites W2072609058 @default.
• W2021837354 cites W2073541816 @default.
• W2021837354 cites W2085075565 @default.
• W2021837354 cites W2087454739 @default.
• W2021837354 cites W2135417200 @default.
• W2021837354 doi "https://doi.org/10.1016/s0024-3205(99)00652-9" @default.
• W2021837354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10698354" @default.
• W2021837354 hasPublicationYear "2000" @default.
• W2021837354 type Work @default.
• W2021837354 sameAs 2021837354 @default.
• W2021837354 citedByCount "30" @default.
• W2021837354 countsByYear W20218373542012 @default.
• W2021837354 countsByYear W20218373542014 @default.
• W2021837354 countsByYear W20218373542015 @default.
• W2021837354 countsByYear W20218373542016 @default.
• W2021837354 countsByYear W20218373542017 @default.
• W2021837354 countsByYear W20218373542018 @default.
• W2021837354 countsByYear W20218373542019 @default.
• W2021837354 countsByYear W20218373542020 @default.
• W2021837354 countsByYear W20218373542021 @default.
• W2021837354 countsByYear W20218373542023 @default.
• W2021837354 crossrefType "journal-article" @default.
• W2021837354 hasAuthorship W2021837354A5005839193 @default.
• W2021837354 hasAuthorship W2021837354A5009990459 @default.
• W2021837354 hasAuthorship W2021837354A5037890780 @default.
• W2021837354 hasAuthorship W2021837354A5043518143 @default.
• W2021837354 hasAuthorship W2021837354A5043712906 @default.
• W2021837354 hasAuthorship W2021837354A5056242920 @default.
• W2021837354 hasAuthorship W2021837354A5059520363 @default.
• W2021837354 hasConcept C126838900 @default.
• W2021837354 hasConcept C149857219 @default.
• W2021837354 hasConcept C15490471 @default.
• W2021837354 hasConcept C170493617 @default.
• W2021837354 hasConcept C185592680 @default.
• W2021837354 hasConcept C2776673659 @default.
• W2021837354 hasConcept C2778750930 @default.
• W2021837354 hasConcept C2780723003 @default.
• W2021837354 hasConcept C2781063702 @default.
• W2021837354 hasConcept C44937612 @default.
• W2021837354 hasConcept C55493867 @default.
• W2021837354 hasConcept C556039675 @default.
• W2021837354 hasConcept C71240020 @default.
• W2021837354 hasConcept C71924100 @default.
• W2021837354 hasConcept C98274493 @default.
• W2021837354 hasConceptScore W2021837354C126838900 @default.
• W2021837354 hasConceptScore W2021837354C149857219 @default.
• W2021837354 hasConceptScore W2021837354C15490471 @default.
• W2021837354 hasConceptScore W2021837354C170493617 @default.
• W2021837354 hasConceptScore W2021837354C185592680 @default.
• W2021837354 hasConceptScore W2021837354C2776673659 @default.
• W2021837354 hasConceptScore W2021837354C2778750930 @default.
• W2021837354 hasConceptScore W2021837354C2780723003 @default.
• W2021837354 hasConceptScore W2021837354C2781063702 @default.
• W2021837354 hasConceptScore W2021837354C44937612 @default.
• W2021837354 hasConceptScore W2021837354C55493867 @default.
• W2021837354 hasConceptScore W2021837354C556039675 @default.
• W2021837354 hasConceptScore W2021837354C71240020 @default.
• W2021837354 hasConceptScore W2021837354C71924100 @default.
• W2021837354 hasConceptScore W2021837354C98274493 @default.
• W2021837354 hasIssue "9" @default.
• W2021837354 hasLocation W20218373541 @default.
• W2021837354 hasLocation W20218373542 @default.
• W2021837354 hasOpenAccess W2021837354 @default.
• W2021837354 hasPrimaryLocation W20218373541 @default.
• W2021837354 hasRelatedWork W1907823189 @default.
• W2021837354 hasRelatedWork W2008188368 @default.
• W2021837354 hasRelatedWork W2008358082 @default.
• W2021837354 hasRelatedWork W2010943998 @default.
• W2021837354 hasRelatedWork W2021861896 @default.
• W2021837354 hasRelatedWork W2036325470 @default.
• W2021837354 hasRelatedWork W2474560275 @default.
• W2021837354 hasRelatedWork W2809978622 @default.
• W2021837354 hasRelatedWork W4366245898 @default.
• W2021837354 hasRelatedWork W4385197704 @default.
• W2021837354 hasVolume "66" @default.

• next