Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021839477> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2021839477 endingPage "S201" @default.
- W2021839477 startingPage "S201" @default.
- W2021839477 abstract "OBJECTIVE: Inhibitor of apoptosis protein (IAP) family may be closely linked to the development of endometriosis. We sought to determine the difference of IAP family expression and the susceptibility to apoptosis between ovarian endometriomas and eutopic endometrial tissues. DESIGN: Experimental study. MATERIALS AND METHODS: Ectopic endometrial tissue from ovarian endometriomas and matched eutopic endometrial tissue samples were collected from premenopausal women (n=22). Eutopic endometrial tissues (n=20) from infertile women with benign gynecologic diseases and no evidence of endometriosis were used as control. Ectopic or eutopic endometrial stromal cells (ESCs) were isolated from these tissues.Gene and protein expression patterns for IAP family, cIAP-1 (birc2), cIAP-2 (birc3), XIAP (birc4), and survivin (birc5) were evaluated by real-time RT-PCR and immunohistochemical staining. Number of surviving cells and activation of caspases were assessed by WST-8 assay, Annexin-V staining and immunoblotting. RESULTS: All 4 IAP family mRNAs were more intensively expressed in endometriotic tissues derived from ovarian endometrioma compared with those of eutopic endometrial tissues. Survivin mRNA expression in endometriotic tissues showed 2.4-fold increase than the control. IAP family mRNA expression in eutopic endometrial tissues of women with ovarian endometriomas was higher than the control. Both epithelial and stromal cells of ovarian endometriotic tissues exhibited higher protein expression of these 4 IAPs than eutopic endometrial tissues. After induction of apoptosis by staurosporine (SS), 55% of eutopic ESCs survived versus 70% of ectopic ESCs. Procaspase-3 or -7 was more activated by SS in eutopic than in ectopic ESCs. Survivin gene silencing in SS-treated ectopic ESCs led to activation of caspases and increase of apoptotic cells. CONCLUSION: Aberrant expression of IAP family genes in ovarian endometriomas may sustain their abnormal survival in ectopic sites." @default.
- W2021839477 created "2016-06-24" @default.
- W2021839477 creator A5017238643 @default.
- W2021839477 creator A5028337478 @default.
- W2021839477 creator A5033028239 @default.
- W2021839477 creator A5049926214 @default.
- W2021839477 creator A5076556711 @default.
- W2021839477 date "2010-09-01" @default.
- W2021839477 modified "2023-09-28" @default.
- W2021839477 title "Aberrant expression of IAP family in endometriotic cells may cause resistance to apoptosis" @default.
- W2021839477 doi "https://doi.org/10.1016/j.fertnstert.2010.07.779" @default.
- W2021839477 hasPublicationYear "2010" @default.
- W2021839477 type Work @default.
- W2021839477 sameAs 2021839477 @default.
- W2021839477 citedByCount "0" @default.
- W2021839477 crossrefType "journal-article" @default.
- W2021839477 hasAuthorship W2021839477A5017238643 @default.
- W2021839477 hasAuthorship W2021839477A5028337478 @default.
- W2021839477 hasAuthorship W2021839477A5033028239 @default.
- W2021839477 hasAuthorship W2021839477A5049926214 @default.
- W2021839477 hasAuthorship W2021839477A5076556711 @default.
- W2021839477 hasBestOaLocation W20218394771 @default.
- W2021839477 hasConcept C126322002 @default.
- W2021839477 hasConcept C16685009 @default.
- W2021839477 hasConcept C16930146 @default.
- W2021839477 hasConcept C190283241 @default.
- W2021839477 hasConcept C204232928 @default.
- W2021839477 hasConcept C2775975398 @default.
- W2021839477 hasConcept C2777408456 @default.
- W2021839477 hasConcept C2779522080 @default.
- W2021839477 hasConcept C31573885 @default.
- W2021839477 hasConcept C33195913 @default.
- W2021839477 hasConcept C502942594 @default.
- W2021839477 hasConcept C54355233 @default.
- W2021839477 hasConcept C71924100 @default.
- W2021839477 hasConcept C86803240 @default.
- W2021839477 hasConcept C98424977 @default.
- W2021839477 hasConceptScore W2021839477C126322002 @default.
- W2021839477 hasConceptScore W2021839477C16685009 @default.
- W2021839477 hasConceptScore W2021839477C16930146 @default.
- W2021839477 hasConceptScore W2021839477C190283241 @default.
- W2021839477 hasConceptScore W2021839477C204232928 @default.
- W2021839477 hasConceptScore W2021839477C2775975398 @default.
- W2021839477 hasConceptScore W2021839477C2777408456 @default.
- W2021839477 hasConceptScore W2021839477C2779522080 @default.
- W2021839477 hasConceptScore W2021839477C31573885 @default.
- W2021839477 hasConceptScore W2021839477C33195913 @default.
- W2021839477 hasConceptScore W2021839477C502942594 @default.
- W2021839477 hasConceptScore W2021839477C54355233 @default.
- W2021839477 hasConceptScore W2021839477C71924100 @default.
- W2021839477 hasConceptScore W2021839477C86803240 @default.
- W2021839477 hasConceptScore W2021839477C98424977 @default.
- W2021839477 hasIssue "4" @default.
- W2021839477 hasLocation W20218394771 @default.
- W2021839477 hasOpenAccess W2021839477 @default.
- W2021839477 hasPrimaryLocation W20218394771 @default.
- W2021839477 hasRelatedWork W1985665318 @default.
- W2021839477 hasRelatedWork W2034752366 @default.
- W2021839477 hasRelatedWork W2105698848 @default.
- W2021839477 hasRelatedWork W2149787400 @default.
- W2021839477 hasRelatedWork W2364023809 @default.
- W2021839477 hasRelatedWork W2373603509 @default.
- W2021839477 hasRelatedWork W2390615972 @default.
- W2021839477 hasRelatedWork W2782592116 @default.
- W2021839477 hasRelatedWork W2827491990 @default.
- W2021839477 hasRelatedWork W3146483921 @default.
- W2021839477 hasVolume "94" @default.
- W2021839477 isParatext "false" @default.
- W2021839477 isRetracted "false" @default.
- W2021839477 magId "2021839477" @default.
- W2021839477 workType "article" @default.