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• W2021841496 endingPage "e15528" @default.
• W2021841496 startingPage "e15528" @default.
• W2021841496 abstract "In Streptococcus mutans, the global response regulator CovR plays an important role in biofilm formation, stress-tolerance response, and caries production. We have previously shown that CovR acts as a transcriptional repressor by binding to the upstream promoter regions of its target genes. Here, we report that in vivo, CovR activates the transcription of SMU.1882, which encodes a small peptide containing a double-glycine motif. We also show that SMU.1882 is transcriptionally linked to comA that encodes a putative ABC transporter protein. Several genes from man gene clusters that encode mannose phosphotranferase system flank SMU.1882 -comA genes. Genomic comparison with other streptococci indicates that SMU.1882 is uniquely present in S. mutans, while the man operon is conserved among all streptococci, suggesting that a genetic rearrangement might have taken place at this locus. With the use of a transcriptional reporter system and semi-quantitative RT-PCR, we demonstrated the transcriptional regulation of SMU.1882 by CovR. In vitro gel shift and DNase I foot-printing analyses with purified CovR suggest that CovR binds to a large region surrounding the -10 region of the P(1882). Using this information and comparing with other CovR regulated promoters, we have developed a putative consensus binding sequence for CovR. Although CovR binds to P(1882), in vitro experiments using purified S. mutans RpoD, E. coli RNA polymerase, and CovR did not activate transcription from this promoter. Thus, we speculate that in vivo, CovR may interfere with the binding of a repressor or requires a cofactor." @default.
• W2021841496 created "2016-06-24" @default.
• W2021841496 creator A5045681355 @default.
• W2021841496 creator A5072924694 @default.
• W2021841496 creator A5074319161 @default.
• W2021841496 date "2010-11-22" @default.
• W2021841496 modified "2023-09-27" @default.
• W2021841496 title "Activation of the SMU.1882 Transcription by CovR in Streptococcus mutans" @default.
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• W2021841496 doi "https://doi.org/10.1371/journal.pone.0015528" @default.
• W2021841496 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2989922" @default.
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• W2021841496 hasPublicationYear "2010" @default.
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