FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021844666> ?p ?o ?g. }

• W2021844666 endingPage "2507" @default.
• W2021844666 startingPage "2495" @default.
• W2021844666 abstract "The process of postnatal angiogenesis plays a crucial role in pathogenesis of numerous diseases, including but not limited to tumor growth/metastasis, diabetic retinopathy, and in tissue remodeling upon injury. However, the molecular events underlying this complex process are not well understood and numerous issues remain controversial, including the regulatory function of integrin receptors. To analyze the role of integrin phosphorylation and signaling in angiogenesis, we generated knock-in mice that express a mutant β3 integrin unable to undergo tyrosine phosphorylation. Two distinct models of pathological angiogenesis revealed that neovascularization is impaired in mutant β3 knock-in mice. In an ex vivo angiogenesis assay, mutant β3 knock-in endothelial cells did not form complete capillaries in response to vascular endothelial growth factor (VEGF) stimulation. At the cellular level, defective tyrosine phosphorylation in mutant β3 knock-in cells resulted in impaired adhesion, spreading, and migration of endothelial cells. At the molecular level, VEGF stimulated complex formation between VEGF receptor-2 and β3 integrin in wild-type but not in mutant β3 knock-in endothelial cells. Moreover, phosphorylation of VEGF receptor-2 was significantly reduced in cells expressing mutant β3 compared to wild type, leading to impaired integrin activation in these cells. These findings provide novel mechanistic insights into the role of integrin–VEGF axis in pathological angiogenesis." @default.
• W2021844666 created "2016-06-24" @default.
• W2021844666 creator A5000641347 @default.
• W2021844666 creator A5009359919 @default.
• W2021844666 creator A5021348310 @default.
• W2021844666 creator A5089100825 @default.
• W2021844666 date "2006-10-09" @default.
• W2021844666 modified "2023-10-18" @default.
• W2021844666 title "Integrin signaling is critical for pathological angiogenesis" @default.
• W2021844666 cites W1513677920 @default.
• W2021844666 cites W1576773659 @default.
• W2021844666 cites W1582963778 @default.
• W2021844666 cites W1925247341 @default.
• W2021844666 cites W1966454841 @default.
• W2021844666 cites W1969937534 @default.
• W2021844666 cites W1976424643 @default.
• W2021844666 cites W1985110057 @default.
• W2021844666 cites W1991503015 @default.
• W2021844666 cites W2001753204 @default.
• W2021844666 cites W2014758132 @default.
• W2021844666 cites W2022851623 @default.
• W2021844666 cites W2029773366 @default.
• W2021844666 cites W2039317622 @default.
• W2021844666 cites W2040283898 @default.
• W2021844666 cites W2052664911 @default.
• W2021844666 cites W2062433497 @default.
• W2021844666 cites W2071831930 @default.
• W2021844666 cites W2072743356 @default.
• W2021844666 cites W2074827208 @default.
• W2021844666 cites W2081417168 @default.
• W2021844666 cites W2083980037 @default.
• W2021844666 cites W2085944684 @default.
• W2021844666 cites W2091323735 @default.
• W2021844666 cites W2099646994 @default.
• W2021844666 cites W2100363932 @default.
• W2021844666 cites W2113267611 @default.
• W2021844666 cites W2113324173 @default.
• W2021844666 cites W2123759534 @default.
• W2021844666 cites W2126933366 @default.
• W2021844666 cites W2130527357 @default.
• W2021844666 cites W2134609474 @default.
• W2021844666 cites W2141750075 @default.
• W2021844666 cites W2148854468 @default.
• W2021844666 cites W4250082363 @default.
• W2021844666 doi "https://doi.org/10.1084/jem.20060807" @default.
• W2021844666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2118124" @default.
• W2021844666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17030947" @default.
• W2021844666 hasPublicationYear "2006" @default.
• W2021844666 type Work @default.
• W2021844666 sameAs 2021844666 @default.
• W2021844666 citedByCount "185" @default.
• W2021844666 countsByYear W20218446662012 @default.
• W2021844666 countsByYear W20218446662013 @default.
• W2021844666 countsByYear W20218446662014 @default.
• W2021844666 countsByYear W20218446662015 @default.
• W2021844666 countsByYear W20218446662016 @default.
• W2021844666 countsByYear W20218446662017 @default.
• W2021844666 countsByYear W20218446662018 @default.
• W2021844666 countsByYear W20218446662019 @default.
• W2021844666 countsByYear W20218446662020 @default.
• W2021844666 countsByYear W20218446662021 @default.
• W2021844666 countsByYear W20218446662022 @default.
• W2021844666 countsByYear W20218446662023 @default.
• W2021844666 crossrefType "journal-article" @default.
• W2021844666 hasAuthorship W2021844666A5000641347 @default.
• W2021844666 hasAuthorship W2021844666A5009359919 @default.
• W2021844666 hasAuthorship W2021844666A5021348310 @default.
• W2021844666 hasAuthorship W2021844666A5089100825 @default.
• W2021844666 hasBestOaLocation W20218446661 @default.
• W2021844666 hasConcept C119524353 @default.
• W2021844666 hasConcept C11960822 @default.
• W2021844666 hasConcept C146285616 @default.
• W2021844666 hasConcept C167734588 @default.
• W2021844666 hasConcept C170493617 @default.
• W2021844666 hasConcept C195687474 @default.
• W2021844666 hasConcept C2777025900 @default.
• W2021844666 hasConcept C2777553839 @default.
• W2021844666 hasConcept C2778271429 @default.
• W2021844666 hasConcept C2780394083 @default.
• W2021844666 hasConcept C502942594 @default.
• W2021844666 hasConcept C55493867 @default.
• W2021844666 hasConcept C62478195 @default.
• W2021844666 hasConcept C86803240 @default.
• W2021844666 hasConcept C95444343 @default.
• W2021844666 hasConceptScore W2021844666C119524353 @default.
• W2021844666 hasConceptScore W2021844666C11960822 @default.
• W2021844666 hasConceptScore W2021844666C146285616 @default.
• W2021844666 hasConceptScore W2021844666C167734588 @default.
• W2021844666 hasConceptScore W2021844666C170493617 @default.
• W2021844666 hasConceptScore W2021844666C195687474 @default.
• W2021844666 hasConceptScore W2021844666C2777025900 @default.
• W2021844666 hasConceptScore W2021844666C2777553839 @default.
• W2021844666 hasConceptScore W2021844666C2778271429 @default.
• W2021844666 hasConceptScore W2021844666C2780394083 @default.
• W2021844666 hasConceptScore W2021844666C502942594 @default.
• W2021844666 hasConceptScore W2021844666C55493867 @default.
• W2021844666 hasConceptScore W2021844666C62478195 @default.
• W2021844666 hasConceptScore W2021844666C86803240 @default.

• next