FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021844888> ?p ?o ?g. }

• W2021844888 endingPage "NA" @default.
• W2021844888 startingPage "NA" @default.
• W2021844888 abstract "Peptidylarginine deiminases (PADs) are a group of posttranslational modification enzymes that citrullinate (deiminate) protein arginine residues in a Ca2+-dependent manner. Enzymatic citrullination abolishes positive charges of native protein molecules, inevitably causing significant alterations in their structure and functions. Among the five isoforms of PADs, PAD2 and PAD4 are proved occupants of the central nervous system (CNS), and especially PAD2 is a main PAD enzyme expressed in the CNS. We previously reported that abnormal protein citrullination by PAD2 has been closely associated with the pathogenesis of neurodegenerative disorders such as Alzheimer's disease and prion disease. Protein citrullination in these patients is thought to play a role during the initiation and/or progression of disease. However, the contribution of changes in PAD2 levels, and consequent citrullination, during developmental and aging processes remained unclear. Therefore, we used quantitative real-time RT-PCR, Western blot analysis, and immunohistochemical methods to measure PAD2 expression and localization in the brain during those processes. PAD2 mRNA expression was detected in the brains of mice as early as embryonic day 15, and its expression in cerebral cortex, hippocampus, and cerebellum increased significantly as the animals aged from 3 to 30 months old. No citrullinated proteins were detected during that period. Moreover, we found here, for the first time, that PAD2 localized specifically in the neuronal cells of the cerebral cortex and Purkinje cells of the cerebellum. These findings indicate that, despite PAD2's normally inactive status, it becomes active and citrullinates cellular proteins, but only when the intracellular Ca2+ balance is upset during neurodegenerative changes. © 2009 Wiley-Liss, Inc." @default.
• W2021844888 created "2016-06-24" @default.
• W2021844888 creator A5005607244 @default.
• W2021844888 creator A5011294638 @default.
• W2021844888 creator A5032826032 @default.
• W2021844888 creator A5048388392 @default.
• W2021844888 creator A5048771529 @default.
• W2021844888 creator A5048899607 @default.
• W2021844888 creator A5049205363 @default.
• W2021844888 creator A5082882534 @default.
• W2021844888 creator A5088259122 @default.
• W2021844888 date "2009-01-01" @default.
• W2021844888 modified "2023-09-30" @default.
• W2021844888 title "Developmental and age-related changes of peptidylarginine deiminase 2 in the mouse brain" @default.
• W2021844888 cites W1500939789 @default.
• W2021844888 cites W1593204115 @default.
• W2021844888 cites W1799202546 @default.
• W2021844888 cites W1970100138 @default.
• W2021844888 cites W1980325059 @default.
• W2021844888 cites W1982645430 @default.
• W2021844888 cites W1982741576 @default.
• W2021844888 cites W1987396543 @default.
• W2021844888 cites W1994244586 @default.
• W2021844888 cites W1995734706 @default.
• W2021844888 cites W1997261857 @default.
• W2021844888 cites W1997923201 @default.
• W2021844888 cites W2002832567 @default.
• W2021844888 cites W2005699747 @default.
• W2021844888 cites W2007871841 @default.
• W2021844888 cites W2017212166 @default.
• W2021844888 cites W2019469604 @default.
• W2021844888 cites W2023634268 @default.
• W2021844888 cites W2035052662 @default.
• W2021844888 cites W2038902835 @default.
• W2021844888 cites W2040068123 @default.
• W2021844888 cites W2067903005 @default.
• W2021844888 cites W2071700927 @default.
• W2021844888 cites W2074253758 @default.
• W2021844888 cites W2092905357 @default.
• W2021844888 cites W2100837269 @default.
• W2021844888 cites W2101108802 @default.
• W2021844888 cites W2111901536 @default.
• W2021844888 cites W2113473876 @default.
• W2021844888 cites W2125110523 @default.
• W2021844888 cites W2136932965 @default.
• W2021844888 cites W2159254316 @default.
• W2021844888 cites W4318599862 @default.
• W2021844888 doi "https://doi.org/10.1002/jnr.22255" @default.
• W2021844888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19830834" @default.
• W2021844888 hasPublicationYear "2009" @default.
• W2021844888 type Work @default.
• W2021844888 sameAs 2021844888 @default.
• W2021844888 citedByCount "13" @default.
• W2021844888 countsByYear W20218448882016 @default.
• W2021844888 countsByYear W20218448882017 @default.
• W2021844888 countsByYear W20218448882018 @default.
• W2021844888 countsByYear W20218448882020 @default.
• W2021844888 countsByYear W20218448882022 @default.
• W2021844888 countsByYear W20218448882023 @default.
• W2021844888 crossrefType "journal-article" @default.
• W2021844888 hasAuthorship W2021844888A5005607244 @default.
• W2021844888 hasAuthorship W2021844888A5011294638 @default.
• W2021844888 hasAuthorship W2021844888A5032826032 @default.
• W2021844888 hasAuthorship W2021844888A5048388392 @default.
• W2021844888 hasAuthorship W2021844888A5048771529 @default.
• W2021844888 hasAuthorship W2021844888A5048899607 @default.
• W2021844888 hasAuthorship W2021844888A5049205363 @default.
• W2021844888 hasAuthorship W2021844888A5082882534 @default.
• W2021844888 hasAuthorship W2021844888A5088259122 @default.
• W2021844888 hasConcept C104317684 @default.
• W2021844888 hasConcept C126322002 @default.
• W2021844888 hasConcept C134018914 @default.
• W2021844888 hasConcept C169760540 @default.
• W2021844888 hasConcept C2776415932 @default.
• W2021844888 hasConcept C2776925932 @default.
• W2021844888 hasConcept C2777468819 @default.
• W2021844888 hasConcept C2779129087 @default.
• W2021844888 hasConcept C2779134260 @default.
• W2021844888 hasConcept C2779652256 @default.
• W2021844888 hasConcept C2781041448 @default.
• W2021844888 hasConcept C2781161787 @default.
• W2021844888 hasConcept C48632299 @default.
• W2021844888 hasConcept C515207424 @default.
• W2021844888 hasConcept C53345823 @default.
• W2021844888 hasConcept C55493867 @default.
• W2021844888 hasConcept C71924100 @default.
• W2021844888 hasConcept C86803240 @default.
• W2021844888 hasConcept C95444343 @default.
• W2021844888 hasConceptScore W2021844888C104317684 @default.
• W2021844888 hasConceptScore W2021844888C126322002 @default.
• W2021844888 hasConceptScore W2021844888C134018914 @default.
• W2021844888 hasConceptScore W2021844888C169760540 @default.
• W2021844888 hasConceptScore W2021844888C2776415932 @default.
• W2021844888 hasConceptScore W2021844888C2776925932 @default.
• W2021844888 hasConceptScore W2021844888C2777468819 @default.
• W2021844888 hasConceptScore W2021844888C2779129087 @default.
• W2021844888 hasConceptScore W2021844888C2779134260 @default.
• W2021844888 hasConceptScore W2021844888C2779652256 @default.

• next