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- W2021844988 abstract "Chronotropic effects of 6 coronary vasodilators, carbochromen, dilazep, diltiazem, dipyridamole, nifedipine and verapamil, were compared by close-arterial administration to the isolated, blood-perfused sino-atrial node preparation of the dog. All drugs produced a dose-related decrease in sinus rate, and the order of negative chronotropic potency determined on a weight basis was as follows: nifedipine_??_verapamil>diltiazem>earbochromen_??_dilazep_??_dipyridamole. Higher doses of these drugs except dipyridamole caused atrial standstill. The order of potency causing atrial standstill determined on a weight basis was as follows: nifedipine_??_verapamil>diliiazem>dilazep>carbochromen. Dipyridamole in lower doses produced a negative chronotropic effect alone, but with higher doses a positive chronotropic effect preceded a negative one. Carbochromen in a wide range of doses produced a triphasic response consisting of initial brief positive, succeeding main negative and final gradually-developing slight positive components." @default.
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- W2021844988 date "1977-01-01" @default.
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- W2021844988 title "Chronotropic Effects of Coronary Vasodilators as Assessed in the Isolated, Blood-Perfused Sino-Atrial Node Preparation of the Dog" @default.
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- W2021844988 doi "https://doi.org/10.1620/tjem.121.383" @default.
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