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- W2021851567 abstract "Pulmonary hypertension is a common complication of neonatal respiratory failure, and its pathophysiology is distinct from adult conditions. Fetal sheep and young lambs have been used to develop several relevant animal models for fetal and neonatal pulmonary hypertension. They have numerous advantages, including body size similar to the human neonate, allowing for instrumentation and physiologic study both in utero and after delivery, as well as pulmonary physiology and maturation that is similar to human developmental timelines. This review outlines four models of neonatal pulmonary hypertension in lambs, all of which are created through altering fetal physiology. Three require surgical manipulation of the fetus, including antenatal ductal ligation, creation of congenital diaphragmatic hernia, and placement of aortopulmonary shunts to mimic congenital heart disease with high pulmonary blood flow. A fourth model, created by chronic maternal exposure to hypobaric hypoxia, is also discussed, and may be especially relevant for understanding the influence of fetal insults on adult pulmonary vascular physiology. Each of these models has individual limitations, but all have proved invaluable for the study of neonatal pulmonary hypertension, and have been used extensively to better understand the pathophysiology of the condition as well as for preclinical testing for new therapeutic approaches." @default.
- W2021851567 created "2016-06-24" @default.
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- W2021851567 date "2010-09-01" @default.
- W2021851567 modified "2023-09-27" @default.
- W2021851567 title "Lamb models of pulmonary hypertension" @default.
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- W2021851567 doi "https://doi.org/10.1016/j.ddmod.2011.01.001" @default.
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