FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021855226> ?p ?o ?g. }

• W2021855226 endingPage "329" @default.
• W2021855226 startingPage "318" @default.
• W2021855226 abstract "The gynecologic and obstetric implications of the smooth muscle-relaxing, antiaggregatory prostacyclin and its endogenous antagonist, thromboxane A2, are reviewed. In addition to the vascular wall and circulating platelets, which are primary sources for prostacyclin and thromboxane A2, respectively, reproductive tissues produce great amounts of these prostanoids, evidently for the regulation of the vascular tone and/or vascular platelet interaction. Several gynecologic and obstetric disorders are characterized by abnormalities in prostacyclin and/or thromboxane A2. In primary menorrhagia the uterine release of prostacyclin is increased, and consequently menstrual blood loss can be reduced with various prostaglandin synthesis inhibitors. Prostacyclin relaxes the nonpregnant myometrium in vitro and may also do so in vivo, although intravenous infusion of prostacyclin has no effect upon the uterine contractility in nonpregnant or pregnant subjects. Patients with pelvic endometriosis may have increased levels of prostacyclin and thromboxane A2 metabolites in the peritoneal fluid. The prostacyclin/thromboxane A2 balance shifts to thromboxane A2 dominance in patients with gynecologic cancer. During pregnancy the production of prostacyclin and thromboxane A2 increases in the mother and fetoplacental tissue. Preeclampsia and other chronic placental insufficiency syndromes are accompanied by prostacyclin deficiency in the mother and in fetomaternal tissues and by an overproduction of thromboxane A2, at least in the placenta. These changes may account for the vasoconstriction and platelet hyperactivity, which are pathognomonic for hypertensive pregnancies. By directing the prostacyclin/thromboxane A2 balance to prostacyclin dominance (by dietary manipulation, administration of prostacyclin and/or its analogues, drugs with prostacyclin-stimulating and/or thromboxane A2-inhibiting action), it may be possible to prevent and/or treat hypertensive pregnancy complications in the future." @default.
• W2021855226 created "2016-06-24" @default.
• W2021855226 creator A5009892971 @default.
• W2021855226 creator A5085638217 @default.
• W2021855226 date "1985-06-01" @default.
• W2021855226 modified "2023-10-17" @default.
• W2021855226 title "Prostacyclin and thromboxane in gynecology and obstetrics" @default.
• W2021855226 cites W146503686 @default.
• W2021855226 cites W1490158576 @default.
• W2021855226 cites W1502848733 @default.
• W2021855226 cites W1513297577 @default.
• W2021855226 cites W1532402840 @default.
• W2021855226 cites W1544377408 @default.
• W2021855226 cites W1594610969 @default.
• W2021855226 cites W1601713410 @default.
• W2021855226 cites W1791445800 @default.
• W2021855226 cites W1830635454 @default.
• W2021855226 cites W1964159476 @default.
• W2021855226 cites W1964830004 @default.
• W2021855226 cites W1966575109 @default.
• W2021855226 cites W1967126560 @default.
• W2021855226 cites W1967196000 @default.
• W2021855226 cites W1967359669 @default.
• W2021855226 cites W1967999463 @default.
• W2021855226 cites W1969406540 @default.
• W2021855226 cites W1975074673 @default.
• W2021855226 cites W1978285417 @default.
• W2021855226 cites W1978883377 @default.
• W2021855226 cites W1981581994 @default.
• W2021855226 cites W1982456494 @default.
• W2021855226 cites W1985880790 @default.
• W2021855226 cites W1986522994 @default.
• W2021855226 cites W1987914070 @default.
• W2021855226 cites W1988295692 @default.
• W2021855226 cites W1989987972 @default.
• W2021855226 cites W1992253125 @default.
• W2021855226 cites W1993017386 @default.
• W2021855226 cites W1994560306 @default.
• W2021855226 cites W1996198830 @default.
• W2021855226 cites W2003082542 @default.
• W2021855226 cites W2003455109 @default.
• W2021855226 cites W2004999708 @default.
• W2021855226 cites W2005066826 @default.
• W2021855226 cites W2005471157 @default.
• W2021855226 cites W2005904690 @default.
• W2021855226 cites W2007120547 @default.
• W2021855226 cites W2007654790 @default.
• W2021855226 cites W2008235094 @default.
• W2021855226 cites W2009461879 @default.
• W2021855226 cites W2009628393 @default.
• W2021855226 cites W2010005098 @default.
• W2021855226 cites W2016862873 @default.
• W2021855226 cites W2021403302 @default.
• W2021855226 cites W2022420575 @default.
• W2021855226 cites W2025585517 @default.
• W2021855226 cites W2026540289 @default.
• W2021855226 cites W2029896095 @default.
• W2021855226 cites W2030087792 @default.
• W2021855226 cites W2030714947 @default.
• W2021855226 cites W2032328900 @default.
• W2021855226 cites W2033526345 @default.
• W2021855226 cites W2035746389 @default.
• W2021855226 cites W2035970529 @default.
• W2021855226 cites W2036516685 @default.
• W2021855226 cites W2036751363 @default.
• W2021855226 cites W2038206190 @default.
• W2021855226 cites W2038791603 @default.
• W2021855226 cites W2039695166 @default.
• W2021855226 cites W2041325467 @default.
• W2021855226 cites W2042347519 @default.
• W2021855226 cites W2044060023 @default.
• W2021855226 cites W2044988312 @default.
• W2021855226 cites W2046183301 @default.
• W2021855226 cites W2049400661 @default.
• W2021855226 cites W2051338926 @default.
• W2021855226 cites W2052122280 @default.
• W2021855226 cites W2053490282 @default.
• W2021855226 cites W2055054697 @default.
• W2021855226 cites W2055075407 @default.
• W2021855226 cites W2057725040 @default.
• W2021855226 cites W2059188111 @default.
• W2021855226 cites W2060042161 @default.
• W2021855226 cites W2060999931 @default.
• W2021855226 cites W2065710903 @default.
• W2021855226 cites W2067635854 @default.
• W2021855226 cites W2072033133 @default.
• W2021855226 cites W2072708063 @default.
• W2021855226 cites W2073929737 @default.
• W2021855226 cites W2074849656 @default.
• W2021855226 cites W2075590768 @default.
• W2021855226 cites W2076341941 @default.
• W2021855226 cites W2077367449 @default.
• W2021855226 cites W2077628806 @default.
• W2021855226 cites W2077991340 @default.
• W2021855226 cites W2079900251 @default.
• W2021855226 cites W2080950545 @default.
• W2021855226 cites W2081217563 @default.
• W2021855226 cites W2083517870 @default.

• next