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• W2021855648 abstract "Summary Glycogenolysis, glycogenesis, glyconeogenesis and the enzymes phosphorylase, glycogen synthetase, and fructose-1–6-diphosphatase were investigated in heavy and light platelet populations in order to determine the presence or extent of metabolic heterogeneity. The mean volume of the heavy platelets was approximately 2.4-fold greater than that of the light platelets. Heavy platelets contained 3.4-fold more glycogen and had a 5.9-fold greater rate of glycogenolysis per g wet weight, than light platelets. Heavy platelets incorporated 5.9-fold more [14C]glucose into platelet glycogen when data were expressed per g wet weight, and 1.7-fold more [14C]glucose when data were expressed per μmole of glycogen. This difference in glycogen synthesis was paralleled by a 1.8-fold greater glycogen synthetase activity. Heavy platelets incorporated 3.0-fold more [14C]citrate into platelet glycogen when data were expressed per g wet weight, and 1.4-fold more [14C]citrate when data were expressed per μmol of glycogen. Similar results were obtained utilizing [14C]pyruvate as precursor. This difference in glyconeogenesis was paralleled by a 2.5-fold greater fructose-1–6-diphosphatase activity for heavy platelets." @default.
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• W2021855648 date "1970-08-01" @default.
• W2021855648 modified "2023-09-26" @default.
• W2021855648 title "Heterogeneity of Human Platelets III. GLYCOGEN METABOLISM IN PLATELETS OF DIFFERENT SIZES" @default.
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• W2021855648 doi "https://doi.org/10.1111/j.1365-2141.1970.tb01612.x" @default.
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