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• W2021858982 abstract "Titanium dioxide (TiO2) produced globally is estimated to reach 6.8 million tonnes in 2016. The extensive use of TiO2 will thus result in environmental exposure to these nanoparticles (NPs). At present, there is limited information on the ecotoxicolgical consequences of TiO2 NP exposure focusing on aquatic life. Hence, the aim of this study was to examine toxicity of TiO2NPs to address the risks using a zebrafish model system. In both qualitative and quantitative analyses, TiO2 NP was found to accumulate in gills of treated groups. Decreased activity of acetylcholine esterase as well as activities of both enzymatic and nonenzymatic antioxidants was observed. In contrast, there was an increase in levels of protein content, reactive oxygen species, protein carbonyls, and lipid peroxidation products. Fourier transform infrared spectroscopy (FT-IR) spectra reveal a stress response of gill tissue in TiO2-treated fish. Distortion in the normal architecture of the gill was found upon histological examination. Our results demonstrate that TiO2 NP induced oxidative stress leading to respiratory distress in zebrafish." @default.
• W2021858982 created "2016-06-24" @default.
• W2021858982 creator A5052342275 @default.
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• W2021858982 date "2014-07-03" @default.
• W2021858982 modified "2023-10-04" @default.
• W2021858982 title "Acute exposure to titanium dioxide (TiO₂) induces oxidative stress in zebrafish gill tissues" @default.
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• W2021858982 doi "https://doi.org/10.1080/02772248.2014.987511" @default.
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