FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021861291> ?p ?o ?g. }

• W2021861291 endingPage "2448" @default.
• W2021861291 startingPage "2440" @default.
• W2021861291 abstract "Membrane-derived microvesicles (MVs) are released from the cell surface and are implicated in cell-to-cell communication. We evaluated whether MVs derived from endothelial progenitor cells (EPCs) are able to trigger angiogenesis. We found that EPC-derived MVs were incorporated in endothelial cells by interaction with α4 and β1 integrins expressed on the MV surface. In vitro, MVs promoted endothelial cell survival, proliferation, and organization in capillary-like structures. In vivo, in severe combined immunodeficient (SCID) mice, MV-stimulated human endothelial cells organized in patent vessels. When incubated with RNase, despite their internalization into endothelial cells, MVs failed to induce in vitro and in vivo angiogenic effects. mRNA transfer was shown by transduction of GFP protein in endothelial cells by MVs containing GFP-mRNA and the biologic relevance by the angiogenic effect of MV-mRNA extract delivered by lipofectamine. Microarray ana-lysis and quantitative reverse transcription–polymerase chain reaction (RT-PCR) of MV-mRNA extract indicated that MVs were shuttling a specific subset of cellular mRNA, such as mRNA associated with the PI3K/AKT signaling pathway. Protein expression and functional studies showed that PI3K and eNOS play a critical role in the angiogenic effect of MVs. These results suggest that EPCs may activate angiogenesis in endothelial cells by releasing MVs able to trigger an angiogenic program." @default.
• W2021861291 created "2016-06-24" @default.
• W2021861291 creator A5025014550 @default.
• W2021861291 creator A5029803187 @default.
• W2021861291 creator A5038212184 @default.
• W2021861291 creator A5045074419 @default.
• W2021861291 creator A5049670577 @default.
• W2021861291 creator A5063812862 @default.
• W2021861291 creator A5077458481 @default.
• W2021861291 creator A5081933975 @default.
• W2021861291 creator A5083316535 @default.
• W2021861291 date "2007-10-01" @default.
• W2021861291 modified "2023-10-14" @default.
• W2021861291 title "Endothelial progenitor cell–derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA" @default.
• W2021861291 cites W1499256297 @default.
• W2021861291 cites W1499709640 @default.
• W2021861291 cites W1571387405 @default.
• W2021861291 cites W1927240777 @default.
• W2021861291 cites W1967367827 @default.
• W2021861291 cites W1967664792 @default.
• W2021861291 cites W1977799997 @default.
• W2021861291 cites W1978238305 @default.
• W2021861291 cites W1991517448 @default.
• W2021861291 cites W1996346598 @default.
• W2021861291 cites W1997962028 @default.
• W2021861291 cites W2004185848 @default.
• W2021861291 cites W2015856405 @default.
• W2021861291 cites W2028416116 @default.
• W2021861291 cites W2036391390 @default.
• W2021861291 cites W2038473729 @default.
• W2021861291 cites W2048018195 @default.
• W2021861291 cites W2054792986 @default.
• W2021861291 cites W2060139150 @default.
• W2021861291 cites W2074892413 @default.
• W2021861291 cites W2079220485 @default.
• W2021861291 cites W2086275775 @default.
• W2021861291 cites W2086719224 @default.
• W2021861291 cites W2090175640 @default.
• W2021861291 cites W2090903207 @default.
• W2021861291 cites W2092632463 @default.
• W2021861291 cites W2102453345 @default.
• W2021861291 cites W2105626657 @default.
• W2021861291 cites W2107903949 @default.
• W2021861291 cites W2109134700 @default.
• W2021861291 cites W2112547972 @default.
• W2021861291 cites W2118008248 @default.
• W2021861291 cites W2120865735 @default.
• W2021861291 cites W2125616125 @default.
• W2021861291 cites W2127209890 @default.
• W2021861291 cites W2133653109 @default.
• W2021861291 cites W2150761119 @default.
• W2021861291 cites W2151081166 @default.
• W2021861291 cites W2156887090 @default.
• W2021861291 cites W2160697532 @default.
• W2021861291 cites W2163087495 @default.
• W2021861291 cites W2168438265 @default.
• W2021861291 cites W2320154784 @default.
• W2021861291 cites W4237789690 @default.
• W2021861291 doi "https://doi.org/10.1182/blood-2007-03-078709" @default.
• W2021861291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17536014" @default.
• W2021861291 hasPublicationYear "2007" @default.
• W2021861291 type Work @default.
• W2021861291 sameAs 2021861291 @default.
• W2021861291 citedByCount "839" @default.
• W2021861291 countsByYear W20218612912012 @default.
• W2021861291 countsByYear W20218612912013 @default.
• W2021861291 countsByYear W20218612912014 @default.
• W2021861291 countsByYear W20218612912015 @default.
• W2021861291 countsByYear W20218612912016 @default.
• W2021861291 countsByYear W20218612912017 @default.
• W2021861291 countsByYear W20218612912018 @default.
• W2021861291 countsByYear W20218612912019 @default.
• W2021861291 countsByYear W20218612912020 @default.
• W2021861291 countsByYear W20218612912021 @default.
• W2021861291 countsByYear W20218612912022 @default.
• W2021861291 countsByYear W20218612912023 @default.
• W2021861291 crossrefType "journal-article" @default.
• W2021861291 hasAuthorship W2021861291A5025014550 @default.
• W2021861291 hasAuthorship W2021861291A5029803187 @default.
• W2021861291 hasAuthorship W2021861291A5038212184 @default.
• W2021861291 hasAuthorship W2021861291A5045074419 @default.
• W2021861291 hasAuthorship W2021861291A5049670577 @default.
• W2021861291 hasAuthorship W2021861291A5063812862 @default.
• W2021861291 hasAuthorship W2021861291A5077458481 @default.
• W2021861291 hasAuthorship W2021861291A5081933975 @default.
• W2021861291 hasAuthorship W2021861291A5083316535 @default.
• W2021861291 hasBestOaLocation W20218612911 @default.
• W2021861291 hasConcept C104317684 @default.
• W2021861291 hasConcept C123012128 @default.
• W2021861291 hasConcept C145059251 @default.
• W2021861291 hasConcept C153911025 @default.
• W2021861291 hasConcept C201750760 @default.
• W2021861291 hasConcept C202751555 @default.
• W2021861291 hasConcept C20518536 @default.
• W2021861291 hasConcept C2780152582 @default.
• W2021861291 hasConcept C2780394083 @default.
• W2021861291 hasConcept C2781261824 @default.
• W2021861291 hasConcept C28328180 @default.

• next