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• W2021865624 abstract "The class II transactivator (CIITA) is the master regulator of major histocompatibility complex class II (MHCII) transcription. Its activity is regulated at the post-transcriptional level by phosphorylation and oligomerization. This aggregation mapped to and depended on the phosphorylation of residues between positions 253 and 321 in CIITA, which resulted in a dramatic accumulation of the protein and increased expression of MHCII genes in human promonocytic U937 cells, which represent immature antigen-presenting cells. Thus, the post-transcriptional modification of CIITA plays an important role in the immune response." @default.
• W2021865624 created "2016-06-24" @default.
• W2021865624 creator A5009585913 @default.
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• W2021865624 date "2002-10-15" @default.
• W2021865624 modified "2023-10-06" @default.
• W2021865624 title "Phosphorylation of CIITA directs its oligomerization, accumulation and increased activity on MHCII promoters" @default.
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• W2021865624 doi "https://doi.org/10.1093/emboj/cdf557" @default.
• W2021865624 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/129089" @default.
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