Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021878803> ?p ?o ?g. }
- W2021878803 endingPage "1262" @default.
- W2021878803 startingPage "1253" @default.
- W2021878803 abstract "The development of an effective immunotherapy is an attractive strategy toward cancer treatment. Tumor associated carbohydrate antigens (TACAs) are overexpressed on a variety of cancer cell surfaces, which present tempting targets for anticancer vaccine development. However, such carbohydrates are often poorly immunogenic. To overcome this challenge, we show here that the display of a very weak TACA, the monomeric Tn antigen, on bacteriophage Qβ virus-like particles elicits powerful humoral responses to the carbohydrate. The effects of adjuvants, antigen display pattern, and vaccine dose on the strength and subclasses of antibody responses were established. The local density of antigen rather than the total amount of antigen administered was found to be crucial for induction of high Tn-specific IgG titers. The ability to display antigens in an organized and high density manner is a key advantage of virus-like particles such as Qβ as vaccine carriers. Glycan microarray analysis showed that the antibodies generated were highly selective toward Tn antigens. Furthermore, Qβ elicited much higher levels of IgG antibodies than other types of virus-like particles, and the IgG antibodies produced reacted strongly with the native Tn antigens on human leukemia cells. Thus, Qβ presents a highly attractive platform for the development of carbohydrate-based anticancer vaccines." @default.
- W2021878803 created "2016-06-24" @default.
- W2021878803 creator A5004093525 @default.
- W2021878803 creator A5007713174 @default.
- W2021878803 creator A5016067033 @default.
- W2021878803 creator A5023146929 @default.
- W2021878803 creator A5028539103 @default.
- W2021878803 creator A5032114980 @default.
- W2021878803 creator A5035098574 @default.
- W2021878803 creator A5063979734 @default.
- W2021878803 creator A5091594147 @default.
- W2021878803 date "2013-03-29" @default.
- W2021878803 modified "2023-10-09" @default.
- W2021878803 title "Boosting Immunity to Small Tumor-Associated Carbohydrates with Bacteriophage Qβ Capsids" @default.
- W2021878803 cites W1969964309 @default.
- W2021878803 cites W1972333400 @default.
- W2021878803 cites W1975025931 @default.
- W2021878803 cites W1975930920 @default.
- W2021878803 cites W1977458226 @default.
- W2021878803 cites W1988422289 @default.
- W2021878803 cites W1989427609 @default.
- W2021878803 cites W1989660541 @default.
- W2021878803 cites W1990592004 @default.
- W2021878803 cites W1991676798 @default.
- W2021878803 cites W1991701295 @default.
- W2021878803 cites W1992311913 @default.
- W2021878803 cites W2003232061 @default.
- W2021878803 cites W2005588427 @default.
- W2021878803 cites W2018453381 @default.
- W2021878803 cites W2019479596 @default.
- W2021878803 cites W2026435928 @default.
- W2021878803 cites W2026877849 @default.
- W2021878803 cites W2028589636 @default.
- W2021878803 cites W2029007872 @default.
- W2021878803 cites W2030320705 @default.
- W2021878803 cites W2033086482 @default.
- W2021878803 cites W2036196494 @default.
- W2021878803 cites W2039472971 @default.
- W2021878803 cites W2046667705 @default.
- W2021878803 cites W2048072167 @default.
- W2021878803 cites W2048317707 @default.
- W2021878803 cites W2050057463 @default.
- W2021878803 cites W2053429123 @default.
- W2021878803 cites W2054183568 @default.
- W2021878803 cites W2054822993 @default.
- W2021878803 cites W2055861239 @default.
- W2021878803 cites W2058194911 @default.
- W2021878803 cites W2065516132 @default.
- W2021878803 cites W2065758072 @default.
- W2021878803 cites W2069825381 @default.
- W2021878803 cites W2078731100 @default.
- W2021878803 cites W2080655915 @default.
- W2021878803 cites W2082416168 @default.
- W2021878803 cites W2082718424 @default.
- W2021878803 cites W2083515629 @default.
- W2021878803 cites W2097544123 @default.
- W2021878803 cites W2100474109 @default.
- W2021878803 cites W2104194763 @default.
- W2021878803 cites W2114245966 @default.
- W2021878803 cites W2119281067 @default.
- W2021878803 cites W2136383144 @default.
- W2021878803 cites W2148074744 @default.
- W2021878803 cites W2149913957 @default.
- W2021878803 cites W2153717284 @default.
- W2021878803 cites W2165286214 @default.
- W2021878803 cites W2165624362 @default.
- W2021878803 cites W2167991675 @default.
- W2021878803 cites W2169803204 @default.
- W2021878803 cites W2177385981 @default.
- W2021878803 cites W2330204641 @default.
- W2021878803 doi "https://doi.org/10.1021/cb400060x" @default.
- W2021878803 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3735802" @default.
- W2021878803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23505965" @default.
- W2021878803 hasPublicationYear "2013" @default.
- W2021878803 type Work @default.
- W2021878803 sameAs 2021878803 @default.
- W2021878803 citedByCount "78" @default.
- W2021878803 countsByYear W20218788032014 @default.
- W2021878803 countsByYear W20218788032015 @default.
- W2021878803 countsByYear W20218788032016 @default.
- W2021878803 countsByYear W20218788032017 @default.
- W2021878803 countsByYear W20218788032018 @default.
- W2021878803 countsByYear W20218788032019 @default.
- W2021878803 countsByYear W20218788032020 @default.
- W2021878803 countsByYear W20218788032021 @default.
- W2021878803 countsByYear W20218788032022 @default.
- W2021878803 countsByYear W20218788032023 @default.
- W2021878803 crossrefType "journal-article" @default.
- W2021878803 hasAuthorship W2021878803A5004093525 @default.
- W2021878803 hasAuthorship W2021878803A5007713174 @default.
- W2021878803 hasAuthorship W2021878803A5016067033 @default.
- W2021878803 hasAuthorship W2021878803A5023146929 @default.
- W2021878803 hasAuthorship W2021878803A5028539103 @default.
- W2021878803 hasAuthorship W2021878803A5032114980 @default.
- W2021878803 hasAuthorship W2021878803A5035098574 @default.
- W2021878803 hasAuthorship W2021878803A5063979734 @default.
- W2021878803 hasAuthorship W2021878803A5091594147 @default.
- W2021878803 hasBestOaLocation W20218788032 @default.