Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021882600> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2021882600 endingPage "404" @default.
- W2021882600 startingPage "393" @default.
- W2021882600 abstract "—Adenine nucleotides of guinea-pig cerebral cortical slices were labelled during a 40 min incubation with [14C]adenine. Subsequent incubation of cortical slices with depolarizing agents, such as veratridine, ouabain, batrachotoxin and high concentrations of potassium ions, or with certain psychotropic drugs such as chlorpromazine, chlorimipramine or prenylamine resulted in a reduction in both endogenous and radioactive ATP, accompanied by a marked increase in levels of both endogenous and radioactive cyclic AMP. Reduction of ATP levels during incubation with depolarizing agents, such as veratridine, is probably associated with increased activity of membranal Na+-K+-activated ATPase, while the reduction elicited by psychotropic drugs is proposed to be due to inhibition of mitochondrial synthesis of ATP. With both classes of compounds reduction of ATP levels results in enhanced formation and efflux of adenosine which stimulates formation of cyclic AMP from intracellular ATP in the compartments of brain slices which contain the cyclic AMP-generating systems. Certain classical metabolic inhibitors such as 2,4-dinitrophenol, azide, 1,2-naphthoquinone-8-sulfonate and cyanide also reduce ATP levels and in the case of 2,4-dinitrophenol, cyanide, and azide elicit small but significant accumulations of cyclic AMP. With certain metabolic inhibitors reduction of ATP within the cyclic AMP generating compartments would appear to prevent or reduce the accumulation of cyclic AMP elicited by amines, adenosine or veratridine." @default.
- W2021882600 created "2016-06-24" @default.
- W2021882600 creator A5020191602 @default.
- W2021882600 creator A5033483377 @default.
- W2021882600 date "1974-08-01" @default.
- W2021882600 modified "2023-10-18" @default.
- W2021882600 title "INTERRELATIONSHIPS AMONG THE LEVELS OF ATP, ADENOSINE AND CYCLIC AMP IN INCUBATED SLICES OF GUINEA-PIG CEREBRAL CORTEX: EFFECTS OF DEPOLARIZING AGENTS, PSYCHOTROPIC DRUGS AND METABOLIC INHIBITORS" @default.
- W2021882600 cites W1578589180 @default.
- W2021882600 cites W1719946011 @default.
- W2021882600 cites W1829913204 @default.
- W2021882600 cites W1966142496 @default.
- W2021882600 cites W1975501086 @default.
- W2021882600 cites W1979232179 @default.
- W2021882600 cites W1982024808 @default.
- W2021882600 cites W1983312156 @default.
- W2021882600 cites W1985497777 @default.
- W2021882600 cites W1987346819 @default.
- W2021882600 cites W1992734964 @default.
- W2021882600 cites W1994915770 @default.
- W2021882600 cites W1996466550 @default.
- W2021882600 cites W2003109526 @default.
- W2021882600 cites W2010903979 @default.
- W2021882600 cites W2042139493 @default.
- W2021882600 cites W2045108572 @default.
- W2021882600 cites W2045979759 @default.
- W2021882600 cites W2046849301 @default.
- W2021882600 cites W2047920584 @default.
- W2021882600 cites W2058515772 @default.
- W2021882600 cites W2058916977 @default.
- W2021882600 cites W2062701554 @default.
- W2021882600 cites W2066648805 @default.
- W2021882600 cites W2069180912 @default.
- W2021882600 cites W2090604720 @default.
- W2021882600 cites W2091683419 @default.
- W2021882600 cites W2328389633 @default.
- W2021882600 cites W23434268 @default.
- W2021882600 cites W2401323002 @default.
- W2021882600 doi "https://doi.org/10.1111/j.1471-4159.1974.tb04371.x" @default.
- W2021882600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4371573" @default.
- W2021882600 hasPublicationYear "1974" @default.
- W2021882600 type Work @default.
- W2021882600 sameAs 2021882600 @default.
- W2021882600 citedByCount "53" @default.
- W2021882600 crossrefType "journal-article" @default.
- W2021882600 hasAuthorship W2021882600A5020191602 @default.
- W2021882600 hasAuthorship W2021882600A5033483377 @default.
- W2021882600 hasConcept C12554922 @default.
- W2021882600 hasConcept C178790620 @default.
- W2021882600 hasConcept C185592680 @default.
- W2021882600 hasConcept C2776986425 @default.
- W2021882600 hasConcept C2776991684 @default.
- W2021882600 hasConcept C2778421351 @default.
- W2021882600 hasConcept C2779133857 @default.
- W2021882600 hasConcept C2781417787 @default.
- W2021882600 hasConcept C4141045 @default.
- W2021882600 hasConcept C50952357 @default.
- W2021882600 hasConcept C537181965 @default.
- W2021882600 hasConcept C55493867 @default.
- W2021882600 hasConcept C86803240 @default.
- W2021882600 hasConcept C98274493 @default.
- W2021882600 hasConceptScore W2021882600C12554922 @default.
- W2021882600 hasConceptScore W2021882600C178790620 @default.
- W2021882600 hasConceptScore W2021882600C185592680 @default.
- W2021882600 hasConceptScore W2021882600C2776986425 @default.
- W2021882600 hasConceptScore W2021882600C2776991684 @default.
- W2021882600 hasConceptScore W2021882600C2778421351 @default.
- W2021882600 hasConceptScore W2021882600C2779133857 @default.
- W2021882600 hasConceptScore W2021882600C2781417787 @default.
- W2021882600 hasConceptScore W2021882600C4141045 @default.
- W2021882600 hasConceptScore W2021882600C50952357 @default.
- W2021882600 hasConceptScore W2021882600C537181965 @default.
- W2021882600 hasConceptScore W2021882600C55493867 @default.
- W2021882600 hasConceptScore W2021882600C86803240 @default.
- W2021882600 hasConceptScore W2021882600C98274493 @default.
- W2021882600 hasIssue "2" @default.
- W2021882600 hasLocation W20218826001 @default.
- W2021882600 hasLocation W20218826002 @default.
- W2021882600 hasOpenAccess W2021882600 @default.
- W2021882600 hasPrimaryLocation W20218826001 @default.
- W2021882600 hasRelatedWork W1970707401 @default.
- W2021882600 hasRelatedWork W1978502630 @default.
- W2021882600 hasRelatedWork W1990572648 @default.
- W2021882600 hasRelatedWork W1990616763 @default.
- W2021882600 hasRelatedWork W2020173902 @default.
- W2021882600 hasRelatedWork W2065579742 @default.
- W2021882600 hasRelatedWork W2066648805 @default.
- W2021882600 hasRelatedWork W2093323095 @default.
- W2021882600 hasRelatedWork W2138876041 @default.
- W2021882600 hasRelatedWork W2322935529 @default.
- W2021882600 hasVolume "23" @default.
- W2021882600 isParatext "false" @default.
- W2021882600 isRetracted "false" @default.
- W2021882600 magId "2021882600" @default.
- W2021882600 workType "article" @default.