FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021887860> ?p ?o ?g. }

• W2021887860 endingPage "239" @default.
• W2021887860 startingPage "234" @default.
• W2021887860 abstract "Circulating insulin-like growth factors (IGFs) are bound in complexes which affect their tissue-accessibility. Interstitial fluid is in close proximity to target cells, but the IGF-system is not well-described herein.To perform a thorough comparison of the IGF-system in suction blister fluid (SBF) vs. in serum, with emphasis on bioactive IGF levels.Eight hour study including samples collected in the fasting state (20 h) and after a meal.Clinical research facility.Six healthy males (age 37.0±8.8 years, BMI 22.5±1.4 kg/m(2)) (mean±SD).Serum and SBF concentrations of bioactive IGF (determined in vitro by specific IGF-I receptor (IGF-IR) phosphorylation assay), immunoreactive IGF and IGF binding protein (IGFBP) levels, Western ligand blotting (WLB) of IGFBPs and IGFBP-3 Western immunoblotting (WiB).The ability of SBF to phosphorylate the IGF-IR in vitro was 41±27% higher than that of serum (P=0.007 by repeated measures ANOVA). By contrast, immunoreactive IGF and IGFBP-concentrations were approximately 50% lower in SBF than in serum (all P≤0.002). A marked difference in the composition of IGFBPs between serum and SBF was observed, including 3-fold elevated amounts of IGFBP-3 fragments in SBF (P<0.001). For both IGF-I, IGF-II and IGFBP-2, the effect of food intake differed between serum and SBF (all P≤0.03).Despite lower concentrations, the in vitro IGF bioactivity was higher in SBF than in serum. This may relate to an increased enzymatic IGFBP-degradation and an altered IGFBP-composition in SBF, making more IGF-I and -II accessible to the IGF-IR. The impact of food intake on the IGF system differs between serum and interstitial fluid." @default.
• W2021887860 created "2016-06-24" @default.
• W2021887860 creator A5039752534 @default.
• W2021887860 creator A5040378891 @default.
• W2021887860 creator A5041201756 @default.
• W2021887860 creator A5076005201 @default.
• W2021887860 creator A5085908032 @default.
• W2021887860 date "2012-12-01" @default.
• W2021887860 modified "2023-09-27" @default.
• W2021887860 title "Interstitial fluid contains higher in vitro IGF bioactivity than serum: A study utilizing the suction blister technique" @default.
• W2021887860 cites W1966149024 @default.
• W2021887860 cites W1996224452 @default.
• W2021887860 cites W1996451745 @default.
• W2021887860 cites W1999920704 @default.
• W2021887860 cites W2002914227 @default.
• W2021887860 cites W2014030757 @default.
• W2021887860 cites W2016830471 @default.
• W2021887860 cites W2018257115 @default.
• W2021887860 cites W2024034633 @default.
• W2021887860 cites W2026050607 @default.
• W2021887860 cites W2029481246 @default.
• W2021887860 cites W2041182873 @default.
• W2021887860 cites W2041426179 @default.
• W2021887860 cites W2046826194 @default.
• W2021887860 cites W2061088764 @default.
• W2021887860 cites W2062044370 @default.
• W2021887860 cites W2072067599 @default.
• W2021887860 cites W2079457579 @default.
• W2021887860 cites W2081589502 @default.
• W2021887860 cites W2105550333 @default.
• W2021887860 cites W2122524202 @default.
• W2021887860 cites W2125844609 @default.
• W2021887860 cites W2134593482 @default.
• W2021887860 cites W2145210692 @default.
• W2021887860 cites W2160452185 @default.
• W2021887860 cites W2162072202 @default.
• W2021887860 cites W2168923938 @default.
• W2021887860 cites W292398390 @default.
• W2021887860 cites W4230524791 @default.
• W2021887860 cites W4232789314 @default.
• W2021887860 cites W4239039135 @default.
• W2021887860 cites W4240919585 @default.
• W2021887860 cites W4244597175 @default.
• W2021887860 cites W4245642441 @default.
• W2021887860 doi "https://doi.org/10.1016/j.ghir.2012.08.002" @default.
• W2021887860 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22939216" @default.
• W2021887860 hasPublicationYear "2012" @default.
• W2021887860 type Work @default.
• W2021887860 sameAs 2021887860 @default.
• W2021887860 citedByCount "12" @default.
• W2021887860 countsByYear W20218878602013 @default.
• W2021887860 countsByYear W20218878602014 @default.
• W2021887860 countsByYear W20218878602016 @default.
• W2021887860 countsByYear W20218878602017 @default.
• W2021887860 countsByYear W20218878602019 @default.
• W2021887860 countsByYear W20218878602022 @default.
• W2021887860 crossrefType "journal-article" @default.
• W2021887860 hasAuthorship W2021887860A5039752534 @default.
• W2021887860 hasAuthorship W2021887860A5040378891 @default.
• W2021887860 hasAuthorship W2021887860A5041201756 @default.
• W2021887860 hasAuthorship W2021887860A5076005201 @default.
• W2021887860 hasAuthorship W2021887860A5085908032 @default.
• W2021887860 hasConcept C104317684 @default.
• W2021887860 hasConcept C114874019 @default.
• W2021887860 hasConcept C11960822 @default.
• W2021887860 hasConcept C126322002 @default.
• W2021887860 hasConcept C134018914 @default.
• W2021887860 hasConcept C170493617 @default.
• W2021887860 hasConcept C185592680 @default.
• W2021887860 hasConcept C199289684 @default.
• W2021887860 hasConcept C202751555 @default.
• W2021887860 hasConcept C2775960820 @default.
• W2021887860 hasConcept C2776735168 @default.
• W2021887860 hasConcept C2777746296 @default.
• W2021887860 hasConcept C2779306644 @default.
• W2021887860 hasConcept C2779822359 @default.
• W2021887860 hasConcept C2780689927 @default.
• W2021887860 hasConcept C55493867 @default.
• W2021887860 hasConcept C71924100 @default.
• W2021887860 hasConcept C80862487 @default.
• W2021887860 hasConcept C85265743 @default.
• W2021887860 hasConcept C86803240 @default.
• W2021887860 hasConceptScore W2021887860C104317684 @default.
• W2021887860 hasConceptScore W2021887860C114874019 @default.
• W2021887860 hasConceptScore W2021887860C11960822 @default.
• W2021887860 hasConceptScore W2021887860C126322002 @default.
• W2021887860 hasConceptScore W2021887860C134018914 @default.
• W2021887860 hasConceptScore W2021887860C170493617 @default.
• W2021887860 hasConceptScore W2021887860C185592680 @default.
• W2021887860 hasConceptScore W2021887860C199289684 @default.
• W2021887860 hasConceptScore W2021887860C202751555 @default.
• W2021887860 hasConceptScore W2021887860C2775960820 @default.
• W2021887860 hasConceptScore W2021887860C2776735168 @default.
• W2021887860 hasConceptScore W2021887860C2777746296 @default.
• W2021887860 hasConceptScore W2021887860C2779306644 @default.
• W2021887860 hasConceptScore W2021887860C2779822359 @default.
• W2021887860 hasConceptScore W2021887860C2780689927 @default.
• W2021887860 hasConceptScore W2021887860C55493867 @default.

• next