Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021895704> ?p ?o ?g. }
- W2021895704 endingPage "328" @default.
- W2021895704 startingPage "317" @default.
- W2021895704 abstract "Abstract The SWI/SNF-Brg1 chromatin remodeling protein plays critical roles in cell-cycle control and differentiation through regulation of gene expression. Loss of Brg1 in mice results in early embryonic lethality, and recent studies have implicated a role for Brg1 in somatic stem cell self-renewal and differentiation. However, little is known about Brg1 function in preimplantation embryos and embryonic stem (ES) cells. Here we report that Brg1 is required for ES cell self-renewal and pluripotency. RNA interference-mediated knockdown of Brg1 in blastocysts caused aberrant expression of Oct4 and Nanog. In ES cells, knockdown of Brg1 resulted in phenotypic changes indicative of differentiation, downregulation of self-renewal and pluripotency genes (e.g., Oct4, Sox2, Sall4, Rest), and upregulation of differentiation genes. Using genome-wide promoter analysis (chromatin immunoprecipitation) we found that Brg1 occupied the promoters of key pluripotency-related genes, including Oct4, Sox2, Nanog, Sall4, Rest, and Polycomb group (PcG) proteins. Moreover, Brg1 co-occupied a subset of Oct4, Sox2, Nanog, and PcG protein target genes. These results demonstrate an important role for Brg1 in regulating self-renewal and pluripotency in ES cells." @default.
- W2021895704 created "2016-06-24" @default.
- W2021895704 creator A5056914488 @default.
- W2021895704 creator A5079903100 @default.
- W2021895704 creator A5087282941 @default.
- W2021895704 date "2009-02-01" @default.
- W2021895704 modified "2023-09-23" @default.
- W2021895704 title "SWI/SNF-Brg1 Regulates Self-Renewal and Occupies Core Pluripotency-Related Genes in Embryonic Stem Cells" @default.
- W2021895704 cites W1547610032 @default.
- W2021895704 cites W1608762409 @default.
- W2021895704 cites W1957763880 @default.
- W2021895704 cites W1968931043 @default.
- W2021895704 cites W1990146061 @default.
- W2021895704 cites W1990710362 @default.
- W2021895704 cites W1995486061 @default.
- W2021895704 cites W1995547197 @default.
- W2021895704 cites W2005437050 @default.
- W2021895704 cites W2010031978 @default.
- W2021895704 cites W2012455156 @default.
- W2021895704 cites W2013171182 @default.
- W2021895704 cites W2016161982 @default.
- W2021895704 cites W2017840637 @default.
- W2021895704 cites W2029675257 @default.
- W2021895704 cites W2030802556 @default.
- W2021895704 cites W2035181962 @default.
- W2021895704 cites W2038353249 @default.
- W2021895704 cites W2042673292 @default.
- W2021895704 cites W2058902552 @default.
- W2021895704 cites W2059635468 @default.
- W2021895704 cites W2061266080 @default.
- W2021895704 cites W2066364577 @default.
- W2021895704 cites W2074974586 @default.
- W2021895704 cites W2075428268 @default.
- W2021895704 cites W2084201375 @default.
- W2021895704 cites W2086253822 @default.
- W2021895704 cites W2088335689 @default.
- W2021895704 cites W2088892416 @default.
- W2021895704 cites W2088995337 @default.
- W2021895704 cites W2095377293 @default.
- W2021895704 cites W2096489607 @default.
- W2021895704 cites W2097337853 @default.
- W2021895704 cites W2097848338 @default.
- W2021895704 cites W2107350929 @default.
- W2021895704 cites W2107575419 @default.
- W2021895704 cites W2110015307 @default.
- W2021895704 cites W2110576677 @default.
- W2021895704 cites W2122683221 @default.
- W2021895704 cites W2125987139 @default.
- W2021895704 cites W2126851387 @default.
- W2021895704 cites W2130410032 @default.
- W2021895704 cites W2135313903 @default.
- W2021895704 cites W2136597956 @default.
- W2021895704 cites W2138977668 @default.
- W2021895704 cites W2142046859 @default.
- W2021895704 cites W2150163104 @default.
- W2021895704 cites W2151120155 @default.
- W2021895704 cites W2152326948 @default.
- W2021895704 cites W2153424791 @default.
- W2021895704 cites W2158610627 @default.
- W2021895704 cites W2161949020 @default.
- W2021895704 cites W2162653961 @default.
- W2021895704 cites W2162928535 @default.
- W2021895704 cites W2164683872 @default.
- W2021895704 cites W2166649689 @default.
- W2021895704 cites W2168331489 @default.
- W2021895704 cites W2168390964 @default.
- W2021895704 cites W2169529166 @default.
- W2021895704 doi "https://doi.org/10.1634/stemcells.2008-0710" @default.
- W2021895704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19056910" @default.
- W2021895704 hasPublicationYear "2009" @default.
- W2021895704 type Work @default.
- W2021895704 sameAs 2021895704 @default.
- W2021895704 citedByCount "208" @default.
- W2021895704 countsByYear W20218957042012 @default.
- W2021895704 countsByYear W20218957042013 @default.
- W2021895704 countsByYear W20218957042014 @default.
- W2021895704 countsByYear W20218957042015 @default.
- W2021895704 countsByYear W20218957042016 @default.
- W2021895704 countsByYear W20218957042017 @default.
- W2021895704 countsByYear W20218957042018 @default.
- W2021895704 countsByYear W20218957042019 @default.
- W2021895704 countsByYear W20218957042020 @default.
- W2021895704 countsByYear W20218957042021 @default.
- W2021895704 countsByYear W20218957042022 @default.
- W2021895704 countsByYear W20218957042023 @default.
- W2021895704 crossrefType "journal-article" @default.
- W2021895704 hasAuthorship W2021895704A5056914488 @default.
- W2021895704 hasAuthorship W2021895704A5079903100 @default.
- W2021895704 hasAuthorship W2021895704A5087282941 @default.
- W2021895704 hasBestOaLocation W20218957041 @default.
- W2021895704 hasConcept C101762097 @default.
- W2021895704 hasConcept C104317684 @default.
- W2021895704 hasConcept C107459253 @default.
- W2021895704 hasConcept C134320426 @default.
- W2021895704 hasConcept C145103041 @default.
- W2021895704 hasConcept C148738053 @default.
- W2021895704 hasConcept C150194340 @default.
- W2021895704 hasConcept C153911025 @default.