Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021897445> ?p ?o ?g. }
- W2021897445 endingPage "147" @default.
- W2021897445 startingPage "137" @default.
- W2021897445 abstract "A series of novel thiazole-containing oligopeptides (oligo-1,3-thiazolecarboxamides) interesting specifically with the minor groove of DNA was shown to inhibit human DNA topoisomerase I (topo I). Inhibitory effects of thiazole-containing oligopeptides (TCO) increase with the number of thiazole units in such compounds. Inhibitory properties of TCO containing 3 or 4 thiazole units were shown to be 3–10 times better than those of the well-known natural antibiotic, distamycin A containing pyrrole rings. The structure of various additional groups attached to the N-terminus and C-terminus of TCO had no significant effect on TCO interaction with the complex of DNA and topo I. TCO were shown to be capable of binding with double-stranded DNA (dsDNA), and the majority of TCO analyzed were more effective in binding with dsDNA than distamycin A. Possible reasons for the different effects of distamycin A and TCO on the reaction of relaxation catalyzed by topo I are discussed." @default.
- W2021897445 created "2016-06-24" @default.
- W2021897445 creator A5002603110 @default.
- W2021897445 creator A5006154857 @default.
- W2021897445 creator A5048980451 @default.
- W2021897445 creator A5081504559 @default.
- W2021897445 creator A5087640214 @default.
- W2021897445 creator A5087864126 @default.
- W2021897445 date "2001-06-01" @default.
- W2021897445 modified "2023-09-23" @default.
- W2021897445 title "Inhibition of Human DNA Topoisomerase I by New DNA Minor Groove Ligands: Derivatives of Oligo-1,3-Thiazolecarboxamides" @default.
- W2021897445 cites W1544370487 @default.
- W2021897445 cites W1581614904 @default.
- W2021897445 cites W1591207989 @default.
- W2021897445 cites W1593797571 @default.
- W2021897445 cites W1704248043 @default.
- W2021897445 cites W1973500838 @default.
- W2021897445 cites W1973630105 @default.
- W2021897445 cites W1976396183 @default.
- W2021897445 cites W1982075384 @default.
- W2021897445 cites W1985866185 @default.
- W2021897445 cites W1986514026 @default.
- W2021897445 cites W1990231491 @default.
- W2021897445 cites W2004327252 @default.
- W2021897445 cites W2005610074 @default.
- W2021897445 cites W2006408412 @default.
- W2021897445 cites W2009581957 @default.
- W2021897445 cites W2013412281 @default.
- W2021897445 cites W2019410656 @default.
- W2021897445 cites W2022692463 @default.
- W2021897445 cites W2025388271 @default.
- W2021897445 cites W2025391337 @default.
- W2021897445 cites W2027543850 @default.
- W2021897445 cites W2029570759 @default.
- W2021897445 cites W2031717136 @default.
- W2021897445 cites W2031733136 @default.
- W2021897445 cites W2056449924 @default.
- W2021897445 cites W2056845484 @default.
- W2021897445 cites W2066298893 @default.
- W2021897445 cites W2067326286 @default.
- W2021897445 cites W2067332276 @default.
- W2021897445 cites W2075357854 @default.
- W2021897445 cites W2076334261 @default.
- W2021897445 cites W2076564663 @default.
- W2021897445 cites W2076579453 @default.
- W2021897445 cites W2078288014 @default.
- W2021897445 cites W2081560369 @default.
- W2021897445 cites W2091129135 @default.
- W2021897445 cites W2161634017 @default.
- W2021897445 cites W2949262277 @default.
- W2021897445 cites W323675612 @default.
- W2021897445 cites W4236530034 @default.
- W2021897445 cites W4242306912 @default.
- W2021897445 doi "https://doi.org/10.1089/108729001300338663" @default.
- W2021897445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11446589" @default.
- W2021897445 hasPublicationYear "2001" @default.
- W2021897445 type Work @default.
- W2021897445 sameAs 2021897445 @default.
- W2021897445 citedByCount "4" @default.
- W2021897445 countsByYear W20218974452014 @default.
- W2021897445 crossrefType "journal-article" @default.
- W2021897445 hasAuthorship W2021897445A5002603110 @default.
- W2021897445 hasAuthorship W2021897445A5006154857 @default.
- W2021897445 hasAuthorship W2021897445A5048980451 @default.
- W2021897445 hasAuthorship W2021897445A5081504559 @default.
- W2021897445 hasAuthorship W2021897445A5087640214 @default.
- W2021897445 hasAuthorship W2021897445A5087864126 @default.
- W2021897445 hasConcept C13935069 @default.
- W2021897445 hasConcept C147897179 @default.
- W2021897445 hasConcept C185592680 @default.
- W2021897445 hasConcept C2778464347 @default.
- W2021897445 hasConcept C2779281246 @default.
- W2021897445 hasConcept C3019303373 @default.
- W2021897445 hasConcept C552990157 @default.
- W2021897445 hasConcept C55493867 @default.
- W2021897445 hasConcept C71240020 @default.
- W2021897445 hasConceptScore W2021897445C13935069 @default.
- W2021897445 hasConceptScore W2021897445C147897179 @default.
- W2021897445 hasConceptScore W2021897445C185592680 @default.
- W2021897445 hasConceptScore W2021897445C2778464347 @default.
- W2021897445 hasConceptScore W2021897445C2779281246 @default.
- W2021897445 hasConceptScore W2021897445C3019303373 @default.
- W2021897445 hasConceptScore W2021897445C552990157 @default.
- W2021897445 hasConceptScore W2021897445C55493867 @default.
- W2021897445 hasConceptScore W2021897445C71240020 @default.
- W2021897445 hasIssue "3" @default.
- W2021897445 hasLocation W20218974451 @default.
- W2021897445 hasLocation W20218974452 @default.
- W2021897445 hasOpenAccess W2021897445 @default.
- W2021897445 hasPrimaryLocation W20218974451 @default.
- W2021897445 hasRelatedWork W1514168331 @default.
- W2021897445 hasRelatedWork W1973630105 @default.
- W2021897445 hasRelatedWork W1977392864 @default.
- W2021897445 hasRelatedWork W1999154390 @default.
- W2021897445 hasRelatedWork W2021897445 @default.
- W2021897445 hasRelatedWork W2031066426 @default.
- W2021897445 hasRelatedWork W2045132616 @default.
- W2021897445 hasRelatedWork W2076579453 @default.