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- W2021898692 abstract "Hypodermic needle injection is still the most common method of drug delivery despite its numerous limitations and drawbacks, such as pain, one-shot administration, and risk of infection. Seeking a viable, safe, and pain-free alternative to the over 16 billion injections per year has therefore become a top priority for our modern technological society. Here, a system that uses a pyroelectric cartridge in lieu of the syringe piston as a potential solution is discussed. Upon stimulation, the cartridge electro-draws, at room temperature, an array of drug-encapsulated, biodegradable polymer microneedles, able to deliver into hypodermic tissue both hydrophobic and hydrophilic bioactive agents, according to a predefined chrono-programme. This mould-free and contact-free method permits the fabrication of biodegradable polymer microneedles into a ready-to-use configuration. In fact, they are formed on a flexible substrate/holder by drawing them directly from drop reservoirs, using a controlled electro-hydrodynamic force. Tests of insertion are performed and discussed in order to demonstrate the possibility to prepare microneedles with suitable geometric and mechanical properties using this method." @default.
- W2021898692 created "2016-06-24" @default.
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- W2021898692 date "2014-02-24" @default.
- W2021898692 modified "2023-09-30" @default.
- W2021898692 title "Electro-Drawn Drug-Loaded Biodegradable Polymer Microneedles as a Viable Route to Hypodermic Injection" @default.
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- W2021898692 doi "https://doi.org/10.1002/adfm.201303679" @default.
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