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- W2021900749 abstract "HMB-45 is a monoclonal antibody recently described as being highly specific for melanocytic proliferations of the skin and in metastases of melanotic lesions. To determine a possible role for HMB-45 in ophthalmic pathology, 45 conjunctival lesions, including 23 melanomas, were analyzed using immunohistochemical techniques with anti-S-100 and HMB-45 as primary antibodies. Nineteen (82.6%) of the melanomas exhibited HMB-45 positivity, and 19 (82.6%) contained S-100 protein, with concordance of all but two cases. Seven cases of primary acquired melanosis were studied: one (33%) of three with atypia was HMB-45 positive, as were two (50%) of four without atypia. Among nevi, 1(9.1%) of 11 showed faint staining with HMB-45. Fifteen conjunctival epithelial dysplasias were negative with HMB-45. At present, HMB-45 appears to offer no great advantage over S-100 protein in the analysis of conjunctival melanomas. Its role in the distinction of benign from atypical or malignant junctional melanocytic proliferations remains unclear." @default.
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- W2021900749 date "1991-04-01" @default.
- W2021900749 modified "2023-10-11" @default.
- W2021900749 title "HMB-45 Immunohistochemical Staining of Conjunctival Melanocytic Lesions" @default.
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- W2021900749 doi "https://doi.org/10.1016/s0161-6420(91)32281-4" @default.
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