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• W2021902032 endingPage "214" @default.
• W2021902032 startingPage "205" @default.
• W2021902032 abstract "gamma-Aminobutyric acid (GABA) synaptic pharmacology was studied in cultured mouse spinal cord using various biochemical techniques. The intact cultures were used to study GABA uptake, benzodiazepine (BZ) binding and GABA-stimulated 36Cl-influx, all under similar physiological conditions. The cultures appear to contain a population of GABAergic neurons, since there was evidence of neuronal active transport of [3H]GABA by these cells. There also was a significant population of neuronal BZ receptors based on the finding of clonazepam-displaceable [3H]flunitrazepam (FLU) binding. In addition, the presence of GABA receptors coupled to the BZ receptors was shown by the enhancement of FLU binding by GABA (10-100 microM). GABAA and glycine-coupled Cl- channels were also demonstrated using 36Cl-influx. GABA-induced 36Cl-influx was specific for GABAA agonists, since GABAB receptor agonist, baclofen and other excitatory neurotransmitters did not alter the 36Cl-influx. Both GABA (Km = 9.1 microM) and muscimol (Km = 2.0 microM) produced concentration-dependent increases in 36Cl-influx in the cultures. The GABA-stimulated Cl-influx was blocked by the GABAA receptor antagonist (+)bicuculline (IC50 = 4.5 microM) and by the Cl- channel antagonist picrotoxinin (IC50 = 25 microM). These results indicate that spinal cord cultures are a useful model for comparing the binding characteristics of the GABA receptor complex to the activation of the coupled Cl- channels using the 36Cl-influx assay." @default.
• W2021902032 created "2016-06-24" @default.
• W2021902032 creator A5045323788 @default.
• W2021902032 creator A5076580880 @default.
• W2021902032 date "1989-05-01" @default.
• W2021902032 modified "2023-10-17" @default.
• W2021902032 title "The pharmacological properties of GABA receptor-coupled chloride channels using36Cl-influx in cultured spinal cord neurons" @default.
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• W2021902032 doi "https://doi.org/10.1016/0006-8993(89)90825-1" @default.
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