Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021902988> ?p ?o ?g. }
- W2021902988 endingPage "959" @default.
- W2021902988 startingPage "956" @default.
- W2021902988 abstract "BACKGROUND: In transfusion medicine, anti‐Jk a has been implicated in hemolytic transfusion reactions. Development of anti‐Jk a after transfusion does not always occur after Jk(a–) patients receive at least 1 unit of Jk(a+) blood unit. This study was designed to identify HLA‐DRB1 alleles associated with predisposition to Jk a immunization after blood transfusion or pregnancy. STUDY DESIGN AND METHODS: Genotyping by polymerase chain reaction and sequence‐specific oligonucleotide probe nonradioactive hybridization/sequence‐specific primers was performed in 20 Jk a ‐immunized patients and 200 controls from the same southern European population. RESULTS: Genotyping showed that HLA‐DRB1*01 was significantly more frequent in Jk a ‐immunized patients than controls: 55 percent versus 17 percent (odds ratio [OR], 5.9; confidence interval [CI], 2.3‐15.5; corrected p value < 0.05). Because HLA‐DRB1*0101, DRB1*0102, and DRB1*1001 share a common sequence in their B1 chain, that is, F in 13, R in 71, and A in 74, HLA genetic predisposition was analyzed by comparing patients and controls with respect to the distribution of F13/R71/A74‐positive and ‐negative alleles. Results demonstrated greater positivity of the F13/R71/A74 sequence (DRB1*0101, *0102, or *1001) in patients than in controls: 65 percent versus 19.5 percent (OR, 7.7; CI, 2.9‐20.5; p < 0.001). CONCLUSION: In conclusion, HLA‐DRB1*0101, DRB1*0102, and DRB1*1001, which share a common DRB1 sequence, appeared to be overrepresented in Jk a ‐immunized patients." @default.
- W2021902988 created "2016-06-24" @default.
- W2021902988 creator A5010854010 @default.
- W2021902988 creator A5016135410 @default.
- W2021902988 creator A5035178326 @default.
- W2021902988 creator A5037007419 @default.
- W2021902988 creator A5056054017 @default.
- W2021902988 creator A5066587184 @default.
- W2021902988 creator A5071217496 @default.
- W2021902988 creator A5082313294 @default.
- W2021902988 date "2005-05-31" @default.
- W2021902988 modified "2023-10-13" @default.
- W2021902988 title "HLA-DRB1 alleles and Jka immunization" @default.
- W2021902988 cites W1489147314 @default.
- W2021902988 cites W2017218087 @default.
- W2021902988 cites W2018979938 @default.
- W2021902988 cites W2047309488 @default.
- W2021902988 cites W2074222872 @default.
- W2021902988 cites W2105480599 @default.
- W2021902988 cites W2135577623 @default.
- W2021902988 cites W2163521262 @default.
- W2021902988 cites W4292910450 @default.
- W2021902988 doi "https://doi.org/10.1111/j.1537-2995.2005.04366.x" @default.
- W2021902988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15934994" @default.
- W2021902988 hasPublicationYear "2005" @default.
- W2021902988 type Work @default.
- W2021902988 sameAs 2021902988 @default.
- W2021902988 citedByCount "71" @default.
- W2021902988 countsByYear W20219029882012 @default.
- W2021902988 countsByYear W20219029882013 @default.
- W2021902988 countsByYear W20219029882014 @default.
- W2021902988 countsByYear W20219029882015 @default.
- W2021902988 countsByYear W20219029882016 @default.
- W2021902988 countsByYear W20219029882017 @default.
- W2021902988 countsByYear W20219029882018 @default.
- W2021902988 countsByYear W20219029882019 @default.
- W2021902988 countsByYear W20219029882020 @default.
- W2021902988 countsByYear W20219029882021 @default.
- W2021902988 countsByYear W20219029882022 @default.
- W2021902988 countsByYear W20219029882023 @default.
- W2021902988 crossrefType "journal-article" @default.
- W2021902988 hasAuthorship W2021902988A5010854010 @default.
- W2021902988 hasAuthorship W2021902988A5016135410 @default.
- W2021902988 hasAuthorship W2021902988A5035178326 @default.
- W2021902988 hasAuthorship W2021902988A5037007419 @default.
- W2021902988 hasAuthorship W2021902988A5056054017 @default.
- W2021902988 hasAuthorship W2021902988A5066587184 @default.
- W2021902988 hasAuthorship W2021902988A5071217496 @default.
- W2021902988 hasAuthorship W2021902988A5082313294 @default.
- W2021902988 hasConcept C104317684 @default.
- W2021902988 hasConcept C126322002 @default.
- W2021902988 hasConcept C135763542 @default.
- W2021902988 hasConcept C147483822 @default.
- W2021902988 hasConcept C156957248 @default.
- W2021902988 hasConcept C180754005 @default.
- W2021902988 hasConcept C188280979 @default.
- W2021902988 hasConcept C203014093 @default.
- W2021902988 hasConcept C2779134260 @default.
- W2021902988 hasConcept C2781142222 @default.
- W2021902988 hasConcept C2908647359 @default.
- W2021902988 hasConcept C31467283 @default.
- W2021902988 hasConcept C49105822 @default.
- W2021902988 hasConcept C54355233 @default.
- W2021902988 hasConcept C67636389 @default.
- W2021902988 hasConcept C71924100 @default.
- W2021902988 hasConcept C86803240 @default.
- W2021902988 hasConcept C99454951 @default.
- W2021902988 hasConceptScore W2021902988C104317684 @default.
- W2021902988 hasConceptScore W2021902988C126322002 @default.
- W2021902988 hasConceptScore W2021902988C135763542 @default.
- W2021902988 hasConceptScore W2021902988C147483822 @default.
- W2021902988 hasConceptScore W2021902988C156957248 @default.
- W2021902988 hasConceptScore W2021902988C180754005 @default.
- W2021902988 hasConceptScore W2021902988C188280979 @default.
- W2021902988 hasConceptScore W2021902988C203014093 @default.
- W2021902988 hasConceptScore W2021902988C2779134260 @default.
- W2021902988 hasConceptScore W2021902988C2781142222 @default.
- W2021902988 hasConceptScore W2021902988C2908647359 @default.
- W2021902988 hasConceptScore W2021902988C31467283 @default.
- W2021902988 hasConceptScore W2021902988C49105822 @default.
- W2021902988 hasConceptScore W2021902988C54355233 @default.
- W2021902988 hasConceptScore W2021902988C67636389 @default.
- W2021902988 hasConceptScore W2021902988C71924100 @default.
- W2021902988 hasConceptScore W2021902988C86803240 @default.
- W2021902988 hasConceptScore W2021902988C99454951 @default.
- W2021902988 hasIssue "6" @default.
- W2021902988 hasLocation W20219029881 @default.
- W2021902988 hasLocation W20219029882 @default.
- W2021902988 hasOpenAccess W2021902988 @default.
- W2021902988 hasPrimaryLocation W20219029881 @default.
- W2021902988 hasRelatedWork W2084883631 @default.
- W2021902988 hasRelatedWork W2085748103 @default.
- W2021902988 hasRelatedWork W2098160269 @default.
- W2021902988 hasRelatedWork W2115129295 @default.
- W2021902988 hasRelatedWork W2141158120 @default.
- W2021902988 hasRelatedWork W2467382134 @default.
- W2021902988 hasRelatedWork W2471536761 @default.
- W2021902988 hasRelatedWork W2807106904 @default.