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- W2021909054 abstract "A cell-mediated mutagenesis assay employing cultured primary SENCAR keratinocytes for the metabolism of promutagens, and V-79 fibroblasts as target cells for the resulting genotoxic metabolites, was used to survey the effects of murine beta-interferon (IFN-β) on 7,12-dimethylbenz[a]anthracene (DMBA) and benzo[a]pyrene (BP)-dependent mutagenesis and cytotoxicity. Pre-incubation of the keratinocyte cultures with > 100 units/ml IFN-β, but not mock IFN, partially inhibited DMBA (25–60%) and BP (25–63%) dependent mutagenesis, but had little effect on the cytotoxicities of these agents. The level of inhibition was influenced by the length of keratinocyte pre-incubation with IFN-β, and the concentration of IFN-β, and the number of keratinocytes per nmol of promutagen. IFN-β dependent inhibition of DMBA mutagenesis correlated with alterations in DMBA metabolism, including a decrease in the intra- and extracellular concentrations of the proximal promutagen (±) trans-DMBA-3,4-dihydrodiol." @default.
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- W2021909054 date "1985-01-01" @default.
- W2021909054 modified "2023-09-26" @default.
- W2021909054 title "Interferon-beta inhibits 7, 12-dimethylbenz[a]anthracene-dependent mutagenesis in a keratinocyte cell-mediated mutation assay" @default.
- W2021909054 doi "https://doi.org/10.1093/carcin/6.12.1781" @default.
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