FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021932632> ?p ?o ?g. }

• W2021932632 endingPage "608" @default.
• W2021932632 startingPage "595" @default.
• W2021932632 abstract "As a developmental precursor for diverse periodontal tissues, the dental follicle (DF) harbors great promise for periodontal tissue regeneration. However, development of optimal therapy awaits the answer to a key question that impinges on many issues in development—Do adult progenitor tissues form a homogeneous cell population that differentiates into target tissues when they arrive at the site, or they contain heterogeneous cell populations that are committed to specific fates? To address the homogeneity/heterogeneity question, we analyzed differentiation pathways and markers in several cloned DF cell lines. Our studies revealed that each of our cloned DF lines featured remarkably unique characteristics, indicative of a separate and distinct lineage. One line, DF1, was high in proliferative activity but did not display any mineralization behavior, suggesting that it might be related to a periodontal ligament-type lineage. DF2 was similar to DF1, but featured remarkably high alkaline phosphatase activity indicative of a highly undifferentiated state. DF3 matched the mineralization characteristics of a same stage alveolar bone line AB1 in terms of gene expression and von Kossa staining, indicating that DF3 might be of cementoblastic or alveolar bone osteoblastic lineage. To verify the multilineage potential of the DF for purposes of tissue engineering, a series of differentiation induction experiments was conducted. For identification purposes, characteristics of these heterogeneous follicular progenitor cells were compared with follicle components in tissue sections of the postnatal developing periodontium. The presence of heterogeneous cell populations in the DF mirrors individual developmental pathways in the formation of the dental integument. The profound cellular heterogeneity of the DF as an adult progenitor for tissue regeneration also suggests that heterogeneous cellular constituents might play as much of a role in tissue regeneration as the inducible characteristics of individual lineages might do." @default.
• W2021932632 created "2016-06-24" @default.
• W2021932632 creator A5001267309 @default.
• W2021932632 creator A5024689804 @default.
• W2021932632 creator A5043727250 @default.
• W2021932632 creator A5072533942 @default.
• W2021932632 date "2006-08-01" @default.
• W2021932632 modified "2023-10-18" @default.
• W2021932632 title "Dental Follicle Progenitor Cell Heterogeneity in the Developing Mouse Periodontium" @default.
• W2021932632 cites W173844952 @default.
• W2021932632 cites W1970621228 @default.
• W2021932632 cites W1972318351 @default.
• W2021932632 cites W1974207011 @default.
• W2021932632 cites W1975974637 @default.
• W2021932632 cites W1991039308 @default.
• W2021932632 cites W2002106980 @default.
• W2021932632 cites W2003523753 @default.
• W2021932632 cites W2010293063 @default.
• W2021932632 cites W2024579131 @default.
• W2021932632 cites W2039065761 @default.
• W2021932632 cites W2046910768 @default.
• W2021932632 cites W2051165362 @default.
• W2021932632 cites W2054956946 @default.
• W2021932632 cites W2056145075 @default.
• W2021932632 cites W2057888154 @default.
• W2021932632 cites W2085924906 @default.
• W2021932632 cites W2089445638 @default.
• W2021932632 cites W2090007672 @default.
• W2021932632 cites W2090946491 @default.
• W2021932632 cites W2091099944 @default.
• W2021932632 cites W2096477042 @default.
• W2021932632 cites W2107277218 @default.
• W2021932632 cites W2112626453 @default.
• W2021932632 cites W2123373142 @default.
• W2021932632 cites W2125382210 @default.
• W2021932632 cites W2138448751 @default.
• W2021932632 cites W2145709076 @default.
• W2021932632 cites W2148907058 @default.
• W2021932632 cites W2151519097 @default.
• W2021932632 cites W2152657611 @default.
• W2021932632 cites W2171360109 @default.
• W2021932632 cites W2192080449 @default.
• W2021932632 cites W22025718 @default.
• W2021932632 cites W2288331653 @default.
• W2021932632 cites W2408912815 @default.
• W2021932632 cites W2409419650 @default.
• W2021932632 cites W2588976301 @default.
• W2021932632 cites W4232757995 @default.
• W2021932632 cites W4239898961 @default.
• W2021932632 cites W4252319003 @default.
• W2021932632 doi "https://doi.org/10.1089/scd.2006.15.595" @default.
• W2021932632 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2738600" @default.
• W2021932632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16978062" @default.
• W2021932632 hasPublicationYear "2006" @default.
• W2021932632 type Work @default.
• W2021932632 sameAs 2021932632 @default.
• W2021932632 citedByCount "128" @default.
• W2021932632 countsByYear W20219326322012 @default.
• W2021932632 countsByYear W20219326322013 @default.
• W2021932632 countsByYear W20219326322014 @default.
• W2021932632 countsByYear W20219326322015 @default.
• W2021932632 countsByYear W20219326322016 @default.
• W2021932632 countsByYear W20219326322017 @default.
• W2021932632 countsByYear W20219326322018 @default.
• W2021932632 countsByYear W20219326322019 @default.
• W2021932632 countsByYear W20219326322020 @default.
• W2021932632 countsByYear W20219326322021 @default.
• W2021932632 countsByYear W20219326322022 @default.
• W2021932632 countsByYear W20219326322023 @default.
• W2021932632 crossrefType "journal-article" @default.
• W2021932632 hasAuthorship W2021932632A5001267309 @default.
• W2021932632 hasAuthorship W2021932632A5024689804 @default.
• W2021932632 hasAuthorship W2021932632A5043727250 @default.
• W2021932632 hasAuthorship W2021932632A5072533942 @default.
• W2021932632 hasBestOaLocation W20219326322 @default.
• W2021932632 hasConcept C104317684 @default.
• W2021932632 hasConcept C144024400 @default.
• W2021932632 hasConcept C148738053 @default.
• W2021932632 hasConcept C1491633281 @default.
• W2021932632 hasConcept C149923435 @default.
• W2021932632 hasConcept C151279780 @default.
• W2021932632 hasConcept C15729860 @default.
• W2021932632 hasConcept C163952510 @default.
• W2021932632 hasConcept C189014844 @default.
• W2021932632 hasConcept C199343813 @default.
• W2021932632 hasConcept C201750760 @default.
• W2021932632 hasConcept C203014093 @default.
• W2021932632 hasConcept C2776211174 @default.
• W2021932632 hasConcept C2778380114 @default.
• W2021932632 hasConcept C28328180 @default.
• W2021932632 hasConcept C2908647359 @default.
• W2021932632 hasConcept C41868710 @default.
• W2021932632 hasConcept C54355233 @default.
• W2021932632 hasConcept C71924100 @default.
• W2021932632 hasConcept C86339819 @default.
• W2021932632 hasConcept C86803240 @default.
• W2021932632 hasConcept C95444343 @default.
• W2021932632 hasConceptScore W2021932632C104317684 @default.

• next