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- W2021933648 abstract "Abstract 1. 1. The distribution of the nonmetabolized glucose analog 3-O- methyl- d -[ 14 C]-glucose and the intracellular concentration of Na+ and K+ were measured in “intact” rat hemidiaphragms, in vitro. 2. 2. 5,5-Diphenylhydantoin (DPH) at concentrations of 0.1 and 0.5 mM produced an increase in internal K+ and a decrease in internal Na+, consistent with stimulation of the Na+ pump. Higher concentrations, 1.0 and 5.0 mM had the opposite effect. Both the stimulatory and the inhibitory effects were potentiated by increased external K+ (16 mM). 3. 3. Sugar transport was inhibited by DPH whenever internal K+ was increased and Na+ decreased and, conversely, sugar transport was stimulated following the opposite ionic changes. The changes in sugar transport were highly and significantly correlated to changes in internal Na+ and K+. These effects were apparent on efflux, as well as on influx of sugar. Inhibition was present with and without insulin but was greater in the presence of the hormone. The inhibitory effect of DPH was abolished by 10−5 M ouabain, which blocks the Na+ pump but not by 10−9 M ouabain. 4. 4. The ionic changes are evidence for a stimulatory effect of DPH on ion transport which changes to inhibition at higher drug concentrations. The effects on sugar transport provide additional evidence for inhibition of sugar transport by low internal Na+ (or high K+) and support the postulated regulatory effect of internal Na+ and/or K+ on the sugar transport mechanism in skeletal muscle." @default.
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- W2021933648 date "1971-10-01" @default.
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- W2021933648 title "Effects of diphenylhydantoin on the transport of Na+ and K+ and the regulation of sugar transport in muscle in vitro" @default.
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- W2021933648 doi "https://doi.org/10.1016/0005-2736(71)90101-5" @default.
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