FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021937351> ?p ?o ?g. }

• W2021937351 endingPage "880" @default.
• W2021937351 startingPage "872" @default.
• W2021937351 abstract "Acetaldehyde and the lipid peroxidation-derived aldehyde malondialdehyde (MDA), are reactive compounds that are generated during ethanol metabolism in the liver, and both aldehydes have been shown to be capable of binding to proteins and forming stable adducts. Because similar concentrations of MDA and acetaldehyde can coexist in the liver during ethanol oxidation, protein adduct formation in the presence of both of these aldehydes was studied under both in vitro and in vivo conditions. When proteins were incubated in the presence of both MDA and acetaldehyde, MDA caused a marked and concentration-dependent increase in the stable binding of acetaldehyde to proteins. Maximum stimulation of binding occurred at approximately a fourfold molar excess of MDA relative to acetaldehyde when concentrations of 1.0 mmol/L and 0.1 mmol/L were tested. The formation of highly fluorescent product or products was associated with the MDA stimulation of acetaldehyde binding, indicating that new and distinct products were being generated. These hybrid adducts of MDA and acetaldehyde have been designated as MAA adducts. An affinity-purified polyclonal antibody was produced that specifically recognized MAA epitopes on proteins and did not cross-react with carrier proteins or proteins modified with either acetaldehyde or MDA alone. A quantitative competitive enzyme-linked immunosorbent assay (ELISA) was developed and detected the presence of MAA-modified proteins in liver cytosol from ethanol-fed rats but not in pair-fed controls. Quantification of the data from the competitive ELISA indicated the presence of approximately 75 pmoles protein-bound MAA per milligram liver cytosol proteins of the ethanol-fed animals. These results indicate that acetaldehyde and MDA can react together in a synergistic manner and generate hybrid adducts (MAA-adducts) and further suggest that MAA adducts may represent a major species of adducts formed in the liver during ethanol metabolism in vivo." @default.
• W2021937351 created "2016-06-24" @default.
• W2021937351 creator A5049420631 @default.
• W2021937351 creator A5055908165 @default.
• W2021937351 creator A5061970794 @default.
• W2021937351 creator A5062853299 @default.
• W2021937351 creator A5075175715 @default.
• W2021937351 date "1996-04-01" @default.
• W2021937351 modified "2023-10-11" @default.
• W2021937351 title "Acetaldehyde and malondialdehyde react together to generate distinct protein adducts in the liver during long-term ethanol administration" @default.
• W2021937351 doi "https://doi.org/10.1002/hep.510230431" @default.
• W2021937351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8666344" @default.
• W2021937351 hasPublicationYear "1996" @default.
• W2021937351 type Work @default.
• W2021937351 sameAs 2021937351 @default.
• W2021937351 citedByCount "225" @default.
• W2021937351 countsByYear W20219373512012 @default.
• W2021937351 countsByYear W20219373512013 @default.
• W2021937351 countsByYear W20219373512014 @default.
• W2021937351 countsByYear W20219373512015 @default.
• W2021937351 countsByYear W20219373512016 @default.
• W2021937351 countsByYear W20219373512017 @default.
• W2021937351 countsByYear W20219373512018 @default.
• W2021937351 countsByYear W20219373512019 @default.
• W2021937351 countsByYear W20219373512020 @default.
• W2021937351 countsByYear W20219373512021 @default.
• W2021937351 countsByYear W20219373512022 @default.
• W2021937351 countsByYear W20219373512023 @default.
• W2021937351 crossrefType "journal-article" @default.
• W2021937351 hasAuthorship W2021937351A5049420631 @default.
• W2021937351 hasAuthorship W2021937351A5055908165 @default.
• W2021937351 hasAuthorship W2021937351A5061970794 @default.
• W2021937351 hasAuthorship W2021937351A5062853299 @default.
• W2021937351 hasAuthorship W2021937351A5075175715 @default.
• W2021937351 hasBestOaLocation W20219373511 @default.
• W2021937351 hasConcept C108204754 @default.
• W2021937351 hasConcept C159654299 @default.
• W2021937351 hasConcept C178790620 @default.
• W2021937351 hasConcept C181199279 @default.
• W2021937351 hasConcept C185592680 @default.
• W2021937351 hasConcept C203014093 @default.
• W2021937351 hasConcept C2777595113 @default.
• W2021937351 hasConcept C2778004101 @default.
• W2021937351 hasConcept C2778401633 @default.
• W2021937351 hasConcept C2780161600 @default.
• W2021937351 hasConcept C2780829032 @default.
• W2021937351 hasConcept C55493867 @default.
• W2021937351 hasConcept C86803240 @default.
• W2021937351 hasConcept C956191 @default.
• W2021937351 hasConcept C98539663 @default.
• W2021937351 hasConceptScore W2021937351C108204754 @default.
• W2021937351 hasConceptScore W2021937351C159654299 @default.
• W2021937351 hasConceptScore W2021937351C178790620 @default.
• W2021937351 hasConceptScore W2021937351C181199279 @default.
• W2021937351 hasConceptScore W2021937351C185592680 @default.
• W2021937351 hasConceptScore W2021937351C203014093 @default.
• W2021937351 hasConceptScore W2021937351C2777595113 @default.
• W2021937351 hasConceptScore W2021937351C2778004101 @default.
• W2021937351 hasConceptScore W2021937351C2778401633 @default.
• W2021937351 hasConceptScore W2021937351C2780161600 @default.
• W2021937351 hasConceptScore W2021937351C2780829032 @default.
• W2021937351 hasConceptScore W2021937351C55493867 @default.
• W2021937351 hasConceptScore W2021937351C86803240 @default.
• W2021937351 hasConceptScore W2021937351C956191 @default.
• W2021937351 hasConceptScore W2021937351C98539663 @default.
• W2021937351 hasIssue "4" @default.
• W2021937351 hasLocation W20219373511 @default.
• W2021937351 hasLocation W20219373512 @default.
• W2021937351 hasOpenAccess W2021937351 @default.
• W2021937351 hasPrimaryLocation W20219373511 @default.
• W2021937351 hasRelatedWork W1917453791 @default.
• W2021937351 hasRelatedWork W1968392127 @default.
• W2021937351 hasRelatedWork W1978484878 @default.
• W2021937351 hasRelatedWork W1985831798 @default.
• W2021937351 hasRelatedWork W2029480522 @default.
• W2021937351 hasRelatedWork W2037417959 @default.
• W2021937351 hasRelatedWork W2037713941 @default.
• W2021937351 hasRelatedWork W2396323081 @default.
• W2021937351 hasRelatedWork W2419097670 @default.
• W2021937351 hasRelatedWork W2419369408 @default.
• W2021937351 hasVolume "23" @default.
• W2021937351 isParatext "false" @default.
• W2021937351 isRetracted "false" @default.
• W2021937351 magId "2021937351" @default.
• W2021937351 workType "article" @default.