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• W2021943782 abstract "The sensitivity of optical biosensors where the detection takes place on a planar gold surface can be improved by making the surface porous. The porosity allows a larger number of ligands per surface area resulting in larger optical shifts when interacting with specifically binding analyte molecules. The porous gold was deposited as a thin layer on a planar gold surface by electrochemical deposition in a solution of tetrachloroaurate and lead acetate. A protein, streptavidin, was adsorbed into the formed porous layer and the time course of the adsorption was monitored by in-situ ellipsometry. When the porous layer was 500 nm in thickness a six-fold increase of the ellipsometric response was obtained compared with a planar gold surface. The dependency of porosity and layer thickness was explained with a mathematical model of the gold/porous gold/protein/solution system." @default.
• W2021943782 created "2016-06-24" @default.
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• W2021943782 date "2000-06-01" @default.
• W2021943782 modified "2023-09-23" @default.
• W2021943782 title "Porous gold surfaces for biosensor applications" @default.
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• W2021943782 doi "https://doi.org/10.1016/s0956-5663(00)00061-0" @default.
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