Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021953901> ?p ?o ?g. }
- W2021953901 endingPage "968" @default.
- W2021953901 startingPage "961" @default.
- W2021953901 abstract "This study assessed the effect of the proton pump inhibitor omeprazole on the bioavailability of the extended-release formulations of oxybutynin and tolterodine. Forty-four healthy volunteers received each of 4 treatments in a 4-period crossover design. The treatments consisted of osmotically controlled extended-release oxybutynin chloride tablets at 10 mg/d or extended-release tolterodine tartrate capsules at 4 mg/d, with and without preceding treatment with 20 mg omeprazole daily for 4 days. Blood samples collected predose and at scheduled time points for 36 hours postdose were analyzed for oxybutynin and its active metabolite, N-desethyloxybutynin, or tolterodine and its active 5-hydroxymethyl metabolite, as appropriate. The AUCinfinity ratios for oxybutynin and its metabolite with and without prior omeprazole fell within the 80% to 125% range (accepted as the criterion for bioequivalence), as did those for tolterodine and its active moiety. The peak concentration ratios for oxybutynin and metabolite also conformed to this range; those for tolterodine did not. Increasing gastric pH with omeprazole does not substantially alter the pharmacokinetic properties of extended-release oxybutynin but may alter those of extended-release tolterodine." @default.
- W2021953901 created "2016-06-24" @default.
- W2021953901 creator A5008094917 @default.
- W2021953901 creator A5042646128 @default.
- W2021953901 creator A5047579820 @default.
- W2021953901 creator A5050732065 @default.
- W2021953901 creator A5053975805 @default.
- W2021953901 creator A5072528594 @default.
- W2021953901 date "2005-08-01" @default.
- W2021953901 modified "2023-10-16" @default.
- W2021953901 title "Effect of the Proton Pump Inhibitor Omeprazole on the Pharmacokinetics of Extended-Release Formulations of Oxybutynin and Tolterodine" @default.
- W2021953901 cites W1496249181 @default.
- W2021953901 cites W1508570619 @default.
- W2021953901 cites W1515159044 @default.
- W2021953901 cites W1986153368 @default.
- W2021953901 cites W1991693093 @default.
- W2021953901 cites W2003516053 @default.
- W2021953901 cites W2008079238 @default.
- W2021953901 cites W2009676497 @default.
- W2021953901 cites W2017922615 @default.
- W2021953901 cites W2026599479 @default.
- W2021953901 cites W2033470362 @default.
- W2021953901 cites W2037306873 @default.
- W2021953901 cites W2044988410 @default.
- W2021953901 cites W2054608212 @default.
- W2021953901 cites W2055149989 @default.
- W2021953901 cites W2064430566 @default.
- W2021953901 cites W2084357603 @default.
- W2021953901 cites W2092477693 @default.
- W2021953901 cites W2098603301 @default.
- W2021953901 cites W2148567690 @default.
- W2021953901 cites W2164799400 @default.
- W2021953901 doi "https://doi.org/10.1177/0091270005278055" @default.
- W2021953901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16027408" @default.
- W2021953901 hasPublicationYear "2005" @default.
- W2021953901 type Work @default.
- W2021953901 sameAs 2021953901 @default.
- W2021953901 citedByCount "9" @default.
- W2021953901 crossrefType "journal-article" @default.
- W2021953901 hasAuthorship W2021953901A5008094917 @default.
- W2021953901 hasAuthorship W2021953901A5042646128 @default.
- W2021953901 hasAuthorship W2021953901A5047579820 @default.
- W2021953901 hasAuthorship W2021953901A5050732065 @default.
- W2021953901 hasAuthorship W2021953901A5053975805 @default.
- W2021953901 hasAuthorship W2021953901A5072528594 @default.
- W2021953901 hasConcept C112705442 @default.
- W2021953901 hasConcept C142724271 @default.
- W2021953901 hasConcept C149151106 @default.
- W2021953901 hasConcept C181389837 @default.
- W2021953901 hasConcept C185592680 @default.
- W2021953901 hasConcept C204787440 @default.
- W2021953901 hasConcept C2777477808 @default.
- W2021953901 hasConcept C2777498785 @default.
- W2021953901 hasConcept C2777844464 @default.
- W2021953901 hasConcept C2778715759 @default.
- W2021953901 hasConcept C2778941218 @default.
- W2021953901 hasConcept C2781020410 @default.
- W2021953901 hasConcept C2781025758 @default.
- W2021953901 hasConcept C42404028 @default.
- W2021953901 hasConcept C55493867 @default.
- W2021953901 hasConcept C71924100 @default.
- W2021953901 hasConcept C98274493 @default.
- W2021953901 hasConceptScore W2021953901C112705442 @default.
- W2021953901 hasConceptScore W2021953901C142724271 @default.
- W2021953901 hasConceptScore W2021953901C149151106 @default.
- W2021953901 hasConceptScore W2021953901C181389837 @default.
- W2021953901 hasConceptScore W2021953901C185592680 @default.
- W2021953901 hasConceptScore W2021953901C204787440 @default.
- W2021953901 hasConceptScore W2021953901C2777477808 @default.
- W2021953901 hasConceptScore W2021953901C2777498785 @default.
- W2021953901 hasConceptScore W2021953901C2777844464 @default.
- W2021953901 hasConceptScore W2021953901C2778715759 @default.
- W2021953901 hasConceptScore W2021953901C2778941218 @default.
- W2021953901 hasConceptScore W2021953901C2781020410 @default.
- W2021953901 hasConceptScore W2021953901C2781025758 @default.
- W2021953901 hasConceptScore W2021953901C42404028 @default.
- W2021953901 hasConceptScore W2021953901C55493867 @default.
- W2021953901 hasConceptScore W2021953901C71924100 @default.
- W2021953901 hasConceptScore W2021953901C98274493 @default.
- W2021953901 hasIssue "8" @default.
- W2021953901 hasLocation W20219539011 @default.
- W2021953901 hasLocation W20219539012 @default.
- W2021953901 hasOpenAccess W2021953901 @default.
- W2021953901 hasPrimaryLocation W20219539011 @default.
- W2021953901 hasRelatedWork W2017999632 @default.
- W2021953901 hasRelatedWork W2021953901 @default.
- W2021953901 hasRelatedWork W2033685750 @default.
- W2021953901 hasRelatedWork W2047763035 @default.
- W2021953901 hasRelatedWork W2056242922 @default.
- W2021953901 hasRelatedWork W2075200277 @default.
- W2021953901 hasRelatedWork W2098603301 @default.
- W2021953901 hasRelatedWork W2166861655 @default.
- W2021953901 hasRelatedWork W2366008708 @default.
- W2021953901 hasRelatedWork W2382698166 @default.
- W2021953901 hasVolume "45" @default.
- W2021953901 isParatext "false" @default.
- W2021953901 isRetracted "false" @default.
- W2021953901 magId "2021953901" @default.