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- W2021954132 abstract "Background In this study the predictive value of the combined dexamethasone/CRH test (DEX/CRH test) for acute antidepressant response was investigated. Methodology/Principal Findings In 114 depressed inpatients suffering from unipolar or bipolar depression (sample 1) the DEX/CRH test was performed at admission and shortly before discharge. During their stay in the hospital patients received different antidepressant treatment regimens. At admission, the rate of nonsuppression (basal cortisol levels >75.3 nmol/l) was 24.6% and was not related to the later therapeutic response. Moreover, 45 out of 114 (39.5%) patients showed an enhancement of HPA axis function at discharge in spite of clinical improvement. In a second sample, 40 depressed patients were treated either with reboxetine or mirtazapine for 5 weeks. The DEX/CRH test was performed before, after 1 week, and after 5 weeks of pharmacotherapy. Attenuation of HPA axis activity after 1 week was associated with a more pronounced alleviation of depressive symptoms after 5-week mirtazapine treatment, whereas downregulation of HPA system activity after 5 weeks was related to clinical response to reboxetine. However, early improvement of HPA axis dysregulation was not necessarily followed by a beneficial treatment outcome. Conclusions/Significance Taken together, performance of a single DEX/CRH test does not predict the therapeutic response. The best predictor for response seems to be an early attenuation of HPA axis activity within 1 or 2 weeks. However, early improvement of HPA system dysfunction is not a sufficient condition for a favourable response. Since a substantial part of depressive patients display a persistence of HPA axis hyperactivity at discharge, downregulation of HPA system function is not a necessary condition for acute clinical improvement either. Our data underline the importance of HPA axis dysregulation for treatment outcome in major depression, although restoration of HPA system dysfunction seems to be neither a necessary nor a sufficient determinant for acute treatment response." @default.
- W2021954132 created "2016-06-24" @default.
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- W2021954132 date "2009-01-30" @default.
- W2021954132 modified "2023-10-12" @default.
- W2021954132 title "The Combined Dexamethasone/CRH Test (DEX/CRH Test) and Prediction of Acute Treatment Response in Major Depression" @default.
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- W2021954132 cites W1794165588 @default.
- W2021954132 cites W1840450113 @default.
- W2021954132 cites W1898069153 @default.
- W2021954132 cites W1964125304 @default.
- W2021954132 cites W1964871537 @default.
- W2021954132 cites W1968260347 @default.
- W2021954132 cites W1973994559 @default.
- W2021954132 cites W1974253960 @default.
- W2021954132 cites W1980055778 @default.
- W2021954132 cites W1981494247 @default.
- W2021954132 cites W1983996222 @default.
- W2021954132 cites W1984694906 @default.
- W2021954132 cites W1984914394 @default.
- W2021954132 cites W1987330686 @default.
- W2021954132 cites W1992863357 @default.
- W2021954132 cites W2001444665 @default.
- W2021954132 cites W2001734650 @default.
- W2021954132 cites W2004283056 @default.
- W2021954132 cites W2005231219 @default.
- W2021954132 cites W2011331030 @default.
- W2021954132 cites W2012471523 @default.
- W2021954132 cites W2016433428 @default.
- W2021954132 cites W2018195755 @default.
- W2021954132 cites W2026131598 @default.
- W2021954132 cites W2026135238 @default.
- W2021954132 cites W2027509507 @default.
- W2021954132 cites W2033468767 @default.
- W2021954132 cites W2035005710 @default.
- W2021954132 cites W2037004891 @default.
- W2021954132 cites W2038028625 @default.
- W2021954132 cites W2040231287 @default.
- W2021954132 cites W2042473905 @default.
- W2021954132 cites W2042902917 @default.
- W2021954132 cites W2047769653 @default.
- W2021954132 cites W2050210712 @default.
- W2021954132 cites W2052459220 @default.
- W2021954132 cites W2055502565 @default.
- W2021954132 cites W2055747883 @default.
- W2021954132 cites W2059696454 @default.
- W2021954132 cites W2060626931 @default.
- W2021954132 cites W2061173648 @default.
- W2021954132 cites W2069410124 @default.
- W2021954132 cites W2070739216 @default.
- W2021954132 cites W2071480913 @default.
- W2021954132 cites W2073216156 @default.
- W2021954132 cites W2077572353 @default.
- W2021954132 cites W2084880238 @default.
- W2021954132 cites W2085339275 @default.
- W2021954132 cites W2087334617 @default.
- W2021954132 cites W2091200799 @default.
- W2021954132 cites W2105453573 @default.
- W2021954132 cites W2114298072 @default.
- W2021954132 cites W2114613490 @default.
- W2021954132 cites W2132358310 @default.
- W2021954132 cites W2132731742 @default.
- W2021954132 cites W2141022364 @default.
- W2021954132 cites W2151451814 @default.
- W2021954132 cites W2154085228 @default.
- W2021954132 cites W2156329605 @default.
- W2021954132 cites W2165668731 @default.
- W2021954132 cites W2166347315 @default.
- W2021954132 cites W23116515 @default.
- W2021954132 cites W2331388788 @default.
- W2021954132 cites W2400730498 @default.
- W2021954132 cites W2402656846 @default.
- W2021954132 cites W2404966986 @default.
- W2021954132 cites W59530324 @default.
- W2021954132 doi "https://doi.org/10.1371/journal.pone.0004324" @default.
- W2021954132 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2629564" @default.
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