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• W2021956739 abstract "Major depression (MD) is a severe, life-threatening, and widespread psychiatric disorder having an incidence of about 340 million cases worldwide. MD ranks fifth among leading causes of global disease burden including developing countries, and by year 2030 it is predicted to represent one of the three leading causes of burden of disease worldwide [1], [2]. MD is also a risk factor for cardiovascular and metabolic diseases, and a major risk factor for suicide [3]. Despite extensive investigations, the exact mechanisms responsible for MD have not been identified, and current therapeutics are based on serendipitous discoveries rather than on bench-to-bedside, targeted drug discovery [4]. In addition, although clinically efficient antidepressant drugs do exist, the situation is in many cases far from ideal. Shortcomings such as low remission and/or high treatment-resistance rates, slow onset of action, side effects, and drug–drug interactions merit the exploration of all plausible agents that are effective, tolerable, and safe, and that improve maintenance of wellness [5]–[8]. Accordingly, there is an enormous need for joint experimental efforts between preclinical and clinical scientists.Understanding MD in its etiology and biological phenomenological characteristics could improve its recognition and treatment [8]–[11]. The present Overview highlights current trends in modern biological psychiatry, neuroscience, and neuroendocrinology by discussing key aspects presented in research papers included in the Special Collection “Stress-Induced Depression and Comorbidities: From Bench to Bedside,” published in this issue of PLoS ONE." @default.
• W2021956739 created "2016-06-24" @default.
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• W2021956739 date "2009-01-30" @default.
• W2021956739 modified "2023-10-03" @default.
• W2021956739 title "Stress and Depression: Preclinical Research and Clinical Implications" @default.
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• W2021956739 doi "https://doi.org/10.1371/journal.pone.0004265" @default.
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