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• W2021966427 abstract "A key event during the formation of lipid-rich foam cells during the progression of atherosclerosis is the uptake of modified low-density lipoproteins (LDL) by macrophages in response to atherogenic mediators in the arterial intima. In addition to scavenger receptor-dependent uptake of LDL, macropinocytosis is known to facilitate the uptake of LDL through the constitutive and passive internalization of large quantities of extracellular solute. In this study we confirm the ability of macropinocytosis to facilitate the uptake of modified LDL by human macrophages and show its modulation by TGF-β, IFN-γ, IL-17A and IL-33. Furthermore we show that the TGF-β-mediated inhibition of macropinocytosis is a Smad-2/-3-independent process." @default.
• W2021966427 created "2016-06-24" @default.
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• W2021966427 date "2013-10-01" @default.
• W2021966427 modified "2023-10-16" @default.
• W2021966427 title "Differential regulation of macropinocytosis in macrophages by cytokines: Implications for foam cell formation and atherosclerosis" @default.
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• W2021966427 doi "https://doi.org/10.1016/j.cyto.2013.05.016" @default.
• W2021966427 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3779350" @default.
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