Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021982005> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2021982005 endingPage "451" @default.
- W2021982005 startingPage "439" @default.
- W2021982005 abstract "C-6 derivatives--hydrazones, phenylhydrazones, dinitrophenylhydrazones, oximes and semicarbazones--of morphinane-6-ones were synthesized and their binding characteristics were studied on rat brain membranes. The dihydromorphinone and oxymorphone derivatives compete for the (3H)naloxone binding sites with high affinity, while the dihydrocodeinone and oxycodone derivatives are less potent. The affinity of the new compounds is decreased for the delta sites as compared to the parent ligands. The ligands bearing bulky substituents also bind with low affinity to the kappa sites. The modification decreased the Na(+)-index of compounds indicating their mixed agonist-antagonist character. The dihydromorphinone derivatives are all capable to block irreversibly the high affinity binding site of (3H)naloxone, whereas the dihydrocodeionone derivatives block irreversibly the low affinity site. A possible mechanism for the inhibition is suggested." @default.
- W2021982005 created "2016-06-24" @default.
- W2021982005 creator A5027111836 @default.
- W2021982005 creator A5027880067 @default.
- W2021982005 creator A5054354138 @default.
- W2021982005 creator A5066954927 @default.
- W2021982005 creator A5085427759 @default.
- W2021982005 creator A5086371482 @default.
- W2021982005 date "1991-01-01" @default.
- W2021982005 modified "2023-10-17" @default.
- W2021982005 title "Irreversible blockade of the high and low affinity (3H) naloxone binding sites by C-6 derivatives of morphinane-6-ones" @default.
- W2021982005 cites W1970012653 @default.
- W2021982005 cites W1979385488 @default.
- W2021982005 cites W1983013099 @default.
- W2021982005 cites W1998384907 @default.
- W2021982005 cites W2000762521 @default.
- W2021982005 cites W2020881213 @default.
- W2021982005 cites W2036553181 @default.
- W2021982005 cites W2039110350 @default.
- W2021982005 cites W2043040755 @default.
- W2021982005 cites W2043813981 @default.
- W2021982005 cites W2082005585 @default.
- W2021982005 cites W2315871337 @default.
- W2021982005 cites W4293247451 @default.
- W2021982005 cites W4300023960 @default.
- W2021982005 cites W6812723 @default.
- W2021982005 doi "https://doi.org/10.1016/0024-3205(91)90500-b" @default.
- W2021982005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1992286" @default.
- W2021982005 hasPublicationYear "1991" @default.
- W2021982005 type Work @default.
- W2021982005 sameAs 2021982005 @default.
- W2021982005 citedByCount "18" @default.
- W2021982005 countsByYear W20219820052012 @default.
- W2021982005 countsByYear W20219820052014 @default.
- W2021982005 countsByYear W20219820052017 @default.
- W2021982005 countsByYear W20219820052021 @default.
- W2021982005 crossrefType "journal-article" @default.
- W2021982005 hasAuthorship W2021982005A5027111836 @default.
- W2021982005 hasAuthorship W2021982005A5027880067 @default.
- W2021982005 hasAuthorship W2021982005A5054354138 @default.
- W2021982005 hasAuthorship W2021982005A5066954927 @default.
- W2021982005 hasAuthorship W2021982005A5085427759 @default.
- W2021982005 hasAuthorship W2021982005A5086371482 @default.
- W2021982005 hasConcept C107824862 @default.
- W2021982005 hasConcept C170493617 @default.
- W2021982005 hasConcept C185592680 @default.
- W2021982005 hasConcept C2776029756 @default.
- W2021982005 hasConcept C2776316548 @default.
- W2021982005 hasConcept C2776885963 @default.
- W2021982005 hasConcept C2778750930 @default.
- W2021982005 hasConcept C2778938600 @default.
- W2021982005 hasConcept C2781063702 @default.
- W2021982005 hasConcept C55493867 @default.
- W2021982005 hasConcept C71240020 @default.
- W2021982005 hasConceptScore W2021982005C107824862 @default.
- W2021982005 hasConceptScore W2021982005C170493617 @default.
- W2021982005 hasConceptScore W2021982005C185592680 @default.
- W2021982005 hasConceptScore W2021982005C2776029756 @default.
- W2021982005 hasConceptScore W2021982005C2776316548 @default.
- W2021982005 hasConceptScore W2021982005C2776885963 @default.
- W2021982005 hasConceptScore W2021982005C2778750930 @default.
- W2021982005 hasConceptScore W2021982005C2778938600 @default.
- W2021982005 hasConceptScore W2021982005C2781063702 @default.
- W2021982005 hasConceptScore W2021982005C55493867 @default.
- W2021982005 hasConceptScore W2021982005C71240020 @default.
- W2021982005 hasIssue "5" @default.
- W2021982005 hasLocation W20219820051 @default.
- W2021982005 hasLocation W20219820052 @default.
- W2021982005 hasOpenAccess W2021982005 @default.
- W2021982005 hasPrimaryLocation W20219820051 @default.
- W2021982005 hasRelatedWork W1982175695 @default.
- W2021982005 hasRelatedWork W1985745001 @default.
- W2021982005 hasRelatedWork W2003567420 @default.
- W2021982005 hasRelatedWork W2007975996 @default.
- W2021982005 hasRelatedWork W2029920185 @default.
- W2021982005 hasRelatedWork W2085337933 @default.
- W2021982005 hasRelatedWork W2092941923 @default.
- W2021982005 hasRelatedWork W2273328095 @default.
- W2021982005 hasRelatedWork W3020847648 @default.
- W2021982005 hasRelatedWork W2503363209 @default.
- W2021982005 hasVolume "48" @default.
- W2021982005 isParatext "false" @default.
- W2021982005 isRetracted "false" @default.
- W2021982005 magId "2021982005" @default.
- W2021982005 workType "article" @default.