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- W2021983344 abstract "The prospect of manipulating endogenous neural stem cells to replace damaged tissue and correct functional deficits represents a novel mechanism for treating a variety of central nervous system disorders. Using human neural precursor cultures and a variety of assays for studying stem cell behavior we have screened two libraries of commercially available compounds using an endpoint high content screening assay. We then performed detailed follow-up mechanistic studies on confirmed hits using endpoint and kinetics assays to characterize and differentiate the mechanisms of action of these compounds. The screening cascade employed successfully identified a number of active compounds with differing mechanisms of action. This approach shows how hits from a phenotypic screen can be prioritized and characterized by high content screening to identify potentially novel mechanisms and druggable targets to take forward into more conventional highthroughput screeening approaches." @default.
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- W2021983344 date "2006-04-01" @default.
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- W2021983344 title "A Morphology- and Kinetics-Based Cascade for Human Neural Cell High Content Screening" @default.
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- W2021983344 doi "https://doi.org/10.1089/adt.2006.4.143" @default.
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