Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021984216> ?p ?o ?g. }
- W2021984216 endingPage "169" @default.
- W2021984216 startingPage "161" @default.
- W2021984216 abstract "Current opinion supports the view that immunity to the surface of the trophozoite-infected erythrocyte (IE) is to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP-1). Here we provide further evidence using the mutant cell line 1776/C10 which no longer expresses PfEMP-1 at the IE surface, due to a subtelomeric deletion in chromosome 9. We have measured antibody reactivity to this mutant in comparison to it's intact isogenic parent line 1776, which does express PfEMP-1, using the sensitive technique of flow cytometry. IgG-specific antibodies (subclass IgG1) in the plasma of hyperimmune adults, reacted to 1776 but never to the 1776/C10 mutant. Antibody subclasses were also measured in individual plasma samples to the surface of trophozoite-IE. Predominantly IgG1 antibodies were detected, with a few individual plasma having additional IgG3 antibodies. Previous studies have used the agglutination assay to measure sero-conversion to PfEMP-1. Here we show that both agglutination and flow cytometric methods are comparable, suggesting that agglutination of trophozoite-IE is mediated by IgG antibodies. Comparison of the isogenic cell lines 1776 and 1776/C10 differing in expression of PfEMP-1 provides further evidence that IgG antibodies, in particular of the cytophilic subclasses, mediate recognition of PfEMP-1." @default.
- W2021984216 created "2016-06-24" @default.
- W2021984216 creator A5002450989 @default.
- W2021984216 creator A5025772093 @default.
- W2021984216 creator A5048534219 @default.
- W2021984216 date "1999-02-01" @default.
- W2021984216 modified "2023-09-24" @default.
- W2021984216 title "Plasmodium falciparum:Analysis of the Antibody Specificity to the Surface of the Trophozoite-Infected Erythrocyte" @default.
- W2021984216 cites W1666218407 @default.
- W2021984216 cites W169321723 @default.
- W2021984216 cites W1894150184 @default.
- W2021984216 cites W1964208524 @default.
- W2021984216 cites W1968176172 @default.
- W2021984216 cites W1969660222 @default.
- W2021984216 cites W1970633327 @default.
- W2021984216 cites W1973480365 @default.
- W2021984216 cites W1990235941 @default.
- W2021984216 cites W2009448974 @default.
- W2021984216 cites W2010795697 @default.
- W2021984216 cites W2013510734 @default.
- W2021984216 cites W2017335417 @default.
- W2021984216 cites W2020637870 @default.
- W2021984216 cites W2021874649 @default.
- W2021984216 cites W2023018455 @default.
- W2021984216 cites W2042788291 @default.
- W2021984216 cites W2043873794 @default.
- W2021984216 cites W2049700891 @default.
- W2021984216 cites W2052523483 @default.
- W2021984216 cites W2058196051 @default.
- W2021984216 cites W2066158156 @default.
- W2021984216 cites W2080443362 @default.
- W2021984216 cites W2081449889 @default.
- W2021984216 cites W2083362566 @default.
- W2021984216 cites W2083442176 @default.
- W2021984216 cites W2083788953 @default.
- W2021984216 cites W2085541452 @default.
- W2021984216 cites W2085972185 @default.
- W2021984216 cites W2088135299 @default.
- W2021984216 cites W2094649888 @default.
- W2021984216 cites W2098809365 @default.
- W2021984216 cites W2104540323 @default.
- W2021984216 cites W2114882317 @default.
- W2021984216 cites W2133791917 @default.
- W2021984216 cites W2144187066 @default.
- W2021984216 cites W2153817725 @default.
- W2021984216 cites W2254664988 @default.
- W2021984216 cites W2336622083 @default.
- W2021984216 cites W2398789039 @default.
- W2021984216 cites W2411533701 @default.
- W2021984216 cites W2411928245 @default.
- W2021984216 cites W4244801817 @default.
- W2021984216 cites W72019451 @default.
- W2021984216 doi "https://doi.org/10.1006/expr.1998.4368" @default.
- W2021984216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9990344" @default.
- W2021984216 hasPublicationYear "1999" @default.
- W2021984216 type Work @default.
- W2021984216 sameAs 2021984216 @default.
- W2021984216 citedByCount "46" @default.
- W2021984216 countsByYear W20219842162012 @default.
- W2021984216 countsByYear W20219842162013 @default.
- W2021984216 countsByYear W20219842162014 @default.
- W2021984216 countsByYear W20219842162017 @default.
- W2021984216 countsByYear W20219842162018 @default.
- W2021984216 countsByYear W20219842162019 @default.
- W2021984216 countsByYear W20219842162021 @default.
- W2021984216 crossrefType "journal-article" @default.
- W2021984216 hasAuthorship W2021984216A5002450989 @default.
- W2021984216 hasAuthorship W2021984216A5025772093 @default.
- W2021984216 hasAuthorship W2021984216A5048534219 @default.
- W2021984216 hasConcept C143508840 @default.
- W2021984216 hasConcept C153911025 @default.
- W2021984216 hasConcept C159047783 @default.
- W2021984216 hasConcept C159654299 @default.
- W2021984216 hasConcept C203014093 @default.
- W2021984216 hasConcept C2778048844 @default.
- W2021984216 hasConcept C2778371730 @default.
- W2021984216 hasConcept C2780898057 @default.
- W2021984216 hasConcept C553184892 @default.
- W2021984216 hasConcept C86803240 @default.
- W2021984216 hasConceptScore W2021984216C143508840 @default.
- W2021984216 hasConceptScore W2021984216C153911025 @default.
- W2021984216 hasConceptScore W2021984216C159047783 @default.
- W2021984216 hasConceptScore W2021984216C159654299 @default.
- W2021984216 hasConceptScore W2021984216C203014093 @default.
- W2021984216 hasConceptScore W2021984216C2778048844 @default.
- W2021984216 hasConceptScore W2021984216C2778371730 @default.
- W2021984216 hasConceptScore W2021984216C2780898057 @default.
- W2021984216 hasConceptScore W2021984216C553184892 @default.
- W2021984216 hasConceptScore W2021984216C86803240 @default.
- W2021984216 hasIssue "2" @default.
- W2021984216 hasLocation W20219842161 @default.
- W2021984216 hasLocation W20219842162 @default.
- W2021984216 hasOpenAccess W2021984216 @default.
- W2021984216 hasPrimaryLocation W20219842161 @default.
- W2021984216 hasRelatedWork W1514481003 @default.
- W2021984216 hasRelatedWork W1976570057 @default.
- W2021984216 hasRelatedWork W1982204565 @default.
- W2021984216 hasRelatedWork W2102261432 @default.